Chuyên viên y tế, Ph.D Than Thi Trang Uyen

Than Thi Trang Uyen, PhD has joined Vinmec since 2017 as a Researcher in VRISG. She has 16 years of experience in cytology and 7 years of experience in wound healing. She obtained her PhD in Biomedical Sciences in Australia (2017) focusing on exosomes released by epidermal skin cells. Currently, her research interests are in biology of exosomes and the clinical application of exosomes from mesenchymal stem for disease treatment. Additionally, she is interested in developing cancer markers from liquid biopsy.

Publications

• Liem Thanh Nguyen, Nghia Trung Tran, Uyen Thi Trang Than, Minh Quang Nguyen, Anh Minh Tran, Phuong Thi Xuan Do, Thao Thi Chu, Tu Dac Nguyen, Anh Viet Bui, Tien Anh Ngo, Van Thanh Hoang, Nhung Thi My Hoang. Optimization of human umbilical cord blood-derived mesenchymal stem cell isolation and culture methods in serum- and xeno-free conditions. Stem Cell Res Ther 13, 15 (2022). https://doi.org/10.1186/s13287-021-02694-y.

• Nguyen, Thu H., Chau M. Duong, Xuan-Hung Nguyen, and Uyen T.T. Than#. 2021. "Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management" Cells 10, no. 11: 2887. https://doi.org/10.3390/cells10112887.

• Hang Minh Le, Lung Tien Nguyen, Diem Huong Hoang, Trung Quoc Bach, Ha Thi Ngoc Nguyen, Hien Thi Mai, Dong Phuong Trinh, Tu Dac Nguyen, Liem Thanh Nguyen, Uyen Thi Trang Than#. Differential Development of Umbilical Cord-Derived Mesenchymal Stem Cells During Long-Term Maintenance in FBS-Supplemented Medium and Xeno- and Serum-Free Culture Medium. Cellular Reprogramming, 2021;23(6):359-369. doi: 10.1089/cell.2021.0050. Epub 2021 Nov 8.

• Nguyen Thu Huyen, Duong Minh Chau, Do Thi Xuan Phuong, Nguyen Thanh Liem, Than Thi Trang Uyen#. Detection of MicroRNAs in Extracellular Vesicles Secreted by Umbilical Cord-Derived Mesenchymal Stem Cells. VNU Journal of Science: Natural Sciences and Technology, 2021. https://doi.org/10.25073/2588-1140/vnunst.5302.

• Than Thi Trang Uyen*, Pham Thi Thanh, Hoang Thi My Nhung. Detection And Quantification Of Growth Factors In Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes And Umbilical Cord Blood-Originated Platelet Rich Plasma. Tạp chí sinh lý học việt nam, 2021.

• Do Thi Xuan Phuong, Nguyen Thi Ngoc Ha, Mai Thi Hien, Hoang Huong Diem, Hoang Thi My Nhung, Nguyen Thanh Liem, Than Thi Trang Uyen Đỗ Thị Xuân Phương, Nguyễn Thị Ngọc Hà, Mai Thị Hiên, Hoàng Hương Diễm, Hoàng Thị Mỹ Nhung, Nguyễn Thanh Liêm, Thân Thị Trang Uyên#. Effect of culture medium and cell origin on the composition of secreted growth factor from mesenchymal stem cells. Vietnam Journal of Physiology, 2021.

• Than Thi Trang Uyen, To Thanh Thuy, Pham Thi Cuong, Hoang Huong Diem, Bui Thi Hong Que, Hoang Thi My Nhung. Isolation of exosomes from differentiated dendritic cells from interferon-α-inducible cord blood monocytes. Journal of Vietnamese Medicine 2020.

• Bui Viet Anh, Chu Thi Thao, Pham Thi Cuong, Nguyen Thi Thu Thuy, Hoang Huong Diem, Bui Thi Van Khanh, Bui Thi Hong Hue, Than Thi Trang Uyen, Nguyen Dac Tu, Tran Thi Ton Hoai, Nguyen Lai Thanh, Nguyen Thanh Liem, Hoang Thi My Nhung. Vγ9γδ T Cell Induction by Human Umbilical Cord Blood Monocytes-Derived, Interferon-α-Stimulated Dendritic Cells. Cancer Control, 2020;27(1):1073274820974025. doi: 10.1177/1073274820974025.

• Hue Thi Hong Bui, Liem Thanh Nguyen, Uyen Thi Trang Than#. Influences of Xeno-Free media on Mesenchymal Stem Cell 3 Expansion for Clinical Application. Tissue Eng Regen Med., 2020. Doi:10.1007/s13770-020-00306-z.

• Diem Huong Hoang, Tu Dac Nguyen, Hoang - Phuong Nguyen, Xuan - Hung Nguyen, Phuong Thi Xuan Do, Duc Van Dang, Phuong Thi Minh Dam, Hue Thi Hong Bui, Mai Quynh Trinh, Duc Minh Vu, Nhung Thi My Hoang, Liem Thanh Nguyen, Uyen Thi Trang Than#. Differential wound healing capacity of mesenchymal stem cell-derived exosomes originated from bone marrow, adipose tissue and umbilical cord under serum- and xeno-free condition. Front. Mol. Biosci., 24 June 2020. https://doi.org/10.3389/fmolb.2020.00119

• Uyen Thi Trang Than*, Huyen Thi Le, Diem Huong Hoang, Xuan-Hung Nguyen, Cuong Thi Pham, Khanh Thi Van Bui, Hue Thi Hong Bui, Phong Van Nguyen, Tu Dac Nguyen, Thu Thi Hoai Do, Thi Thao Chu, Anh Viet Bui, Liem Thanh Nguyen, and Nhung Thi My Hoang. Induction of Antitumor Immunity by Exosomes Isolated from Cryopreserved Cord Blood Monocyte-Derived Dendritic Cells. Int. J. Mol. Sci. 2020, 21(5), 1834. Doi: 10.3390/ijms21051834

• Uyen TT Than*, Dominic Guanzon , Tony J Parker, and David I Leavesley. Deep sequencing micrornas from extracellular membrane vesicles revealed the association of the vesicle cargo with cellular origin. Int J Mol Sci. 2020 Feb 8;21(3). pii: E1141. doi: 10.3390/ijms21031141

• Uyen TT Than*, David I Leavesley, and Tony J Parker. Characteristics and roles of extracellular vesicles released by epidermal keratinocytes. Journal of the European Academy of Dermatology and Venereology. 2019. doi: 10.1111/jdv.15859.

• Phuong Hoang Nguyen, Tinh Van Nguyen, Thao Thi Chu, Tu Dac Nguyen , Thu Thi Hoai Nguyen, Linh-Huyen Truong, Anh Viet Bui, Tien Anh Ngo, Uyen Thi Trang Than, and Liem Thanh Nguyen. Factors affecting human umbilical cord blood quality prior to cryopreservation: the importance of birth weight and gestational age. Biopreservation and Biobanking, 2019. Doi: 10.1089/bio.2019.0063

• Hoang Huong Diem, Bui Thi Van Khanh, Hoang Thi My Nhung, Nguyen Thanh Liem, Than Thi Trang Uyen#. Initial characterization of exosomes released by umbilical cord-derived mesenchymal stem cells and mature dendritic cells, under “Good Manufacturing Practice” condition. Vietnam Journal of Science, Technology and Engineering. 2019, 61:3, p.45-51, doi: 10.31276/VJSTE.61(3).45-51.

• Uyen TT Than* #, Dominic Guanzon, James A Broadbent, David I Leavesley, Carlos Salomon, and Tony J parker.  Differential expression of keratinocyte-derived extracellular vesicle mirnas discriminate exosomes from apoptotic bodies and microvesicles. Front Endocrinol (Lausanne). 2018; 9: 535. doi: 10.3389/fendo.2018.00535.

• Chu Thị Thao, Than Thi Trang Uyen, Nguyen Dac Tu, Nguyen Hoang Phuong, Truong Linh Huyen, Nguyen Van Tinh. Factors associated with CD34+ cell number in cord blood units cryopreserved at Vinmec in 20017. Vietnam Medical Journal. 2018

• Uyen Thi Trang Than. Extracellular membrane vesicles from keratinocytes. https://eprints.qut.edu.au/. 2017.

• Uyen Thi Trang Than, Dominic Guazon, David Leavesly, Tony Parker. Association of extracellular membrane vesicles with cutaneous wound healing. Int. J. Mol. Sci., 2017, 18, 956; doi:10.3390/ijms18050956

• Uyen Thi Trang Than, Dominic Guanzon, Lucas Wager, Kerry Manton, Brett Holoer, David Leavesly. An analysis of exosomes from keratinocytes and fibroblasts. The 5th International Conference on Biotechnology Engineering in Vietnam, Book chapter, Springer publisher, ISBN: 978-3-319-11776-8, IFMBE Proceedings, Volume 46, 2015; doi: 10.1007/978-3-319-11776-8_34.

• Nguyen Thi Hong Hanh, Nguyen Lai Thanh, Nguyen Duy Dieu, Than Thi Trang Uyen, Le Thi Tuyet, Than Thi Linh Quyen. Efficacy of using microinjection of GFP into Galluss galluss domesticus embryonic stem cells using pT2/BH-CVpf-SB11. Journal of Sciences, Vietnam National University, Ha Noi. ISSN 0866-8612, Vol. 26, No. 2S. 2010

• Nguyen Mong Hung, Chu Van Trung, Bui Viet Anh, Phan Ngoc Quang, Vu Minh Đuc, Ha Minh Hiep, Than Thi Trang Uyen, Nguyen Hoang Thinh. Culture of gallus gallus domesticus embryonic stem cells in vitro. Scientific report. NXB KH&KT, tr. 235-238. 2004

Patents

• Procedure for exosome isolation from umbilical cord blood-derived dendritic cell culture. 2019.

Completed Research Support

• Project: Umbilical cord mesenchymal stem cell derived vesicles for skin rejuvenation. Role as PI.

• Project: Dissecting the correlation between cerebrospinal fluid cytokines and therapeutic efficacy in children with autistic spectrum disorders after autologous bone marrow-derived mononuclear cell transplantation. Role as PI.

Ongoing Research Support

• Project: Isolation of extracellular membrane vesicles released by mesenchymal stem cells and investigation of molecules packaged into extracellular vesicles. Role as main researcher and secretary.

• Clinical trial on the role of exosomes from umbilical cord-derived mesenchymal stem cells on skin rejuvenation. Role as co-PI.

• Development of wound healing techniques using stem-cell spray gun and bio-nanomembranes. Role as co-PI.