Meaning of Quantitative Anti Xa

The quantitative anti-Xa test is increasingly important in dose adjustment of the anticoagulant Heparin.

Heparin is a heterogeneous mixture of mucopolysacharride chains of different lengths. Molecular weight from 3000 to 30,000 daltons. Heparin is an anticoagulant, used in the treatment of thrombosis.
In medicine, heparin is extracted from the intestinal membrane of bovine or pig, derived from mast cells of the connective tissue, also known as natural heparin. Currently, there are 4 types of heparin circulating on the market, with the synthesis method depending on the manufacturing company, including: alkaline depolymerization and benzylation (enoxaparin), nitrous acid depolymerization (dalteparin and nadroparin), depolymerization by the enzyme heparinase (tinzaparin).
Heparin is not absorbed from the intestinal tract, so heparin is infused into the body through subcutaneous injection, or injection, intravenous infusion. Heparin is an anticoagulant and is contraindicated in cases of internal bleeding, history of thrombocytopenia, active gastric ulcer, acute pericarditis, and malignant hypertension.
Indications to use Heparin in the following cases:

Venous thromboembolism (prophylactic and curative). Coronary artery thrombosis. Disseminated intravascular coagulation (DIC). Cardiopulmonary bypass surgery. Thrombosis causes cerebral embolism. Prevention of thrombosis in hemodialysis. Other indications: Prevention of hepatic vein occlusion after bone marrow transplantation, exercise-induced asthma... Complications in Heparin treatment may be encountered such as:
Bleeding: common in patients undergoing surgery, having money history of gastrointestinal bleeding, advanced age, renal disease, decreased platelet count, and in patients receiving concomitant antiplatelet therapy Osteoporosis: Due to increased activity of osteoclasts Thrombocytopenia: due to Antibodies against Heparin complex with platelet factor 4. Patients present with bleeding, thrombosis, especially arterial thrombosis. Other effects such as: hypersensitivity reactions, increased liver enzymes, localized skin necrosis, decreased aldosterone, penile erection,... Therefore, to prevent complications that may occur due to overdose or treatment To adjust the dose of heparin in the treatment of thromboembolic disease, it is necessary to evaluate the amount of heparin in the blood based on anti-Xa quantification.

Heparin overdose can cause some dangerous complications such as increased risk of bleeding, decreased coagulation of serin proteases. Therefore, to adjust the dose of heparin accordingly, the doctor will rely on the quantitative anti-Xa test.
Quantification of anti Xa evaluates the concentration of heparin in the blood, which is characterized by anticoagulation. Anti-Xa quantification is important in adjusting the anticoagulant dose of Heparin. Using anti Xa in anticoagulant monitoring regimen to reduce the amount of blood to be transfused, to reduce bleeding complications,...
Anti-Xa activity measuring the anticoagulant effect of Heparin depends only on the concentration of Heparin and Antithrombin. .
Quantitative anti-Xa test is used in evaluating blood levels of heparin in order to adjust the dose of anticoagulant Heparin accordingly. To prevent bleeding complications or thrombocytopenia due to treatment with Heparin necessarily use coagulation tests to monitor.
SEE ALSO:
Coagulation tests you need to know What is the meaning of coagulation test What is a coagulation disorder? Indicators of blood clotting disorders