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IgE antibodies are 1 of 5 immunoglobulin groups: IgM, IgA, IgG, IgE, IgD. IgE globulin is the last of the immunoglobulin family. Not only does it have a unique chemical structure, but it also has a wide range of physiological functions such as autoimmune processes, parasitic infections, type I hypersensitivity reactions, and even venom defense.
1. What is ige antibody?
IgE (Immunoglobulin E) antibodies are antibodies made by the immune system. They are mainly secreted by the mucous membranes of the respiratory and digestive tracts. IgE antibodies have immobilizing properties on plasma cells and basophils, which are cells that can release chemical mediators that cause vasodilation such as serotonin, histamine, and some other substances (prostaglandin, tryptase, eosinophil leucotriene
The role of IgE antibodies is central in allergic sensitization and allergic disorders such as: Asthma , allergic rhinitis and atopic dermatitis These disorders manifest as type hypersensitivity reactions I involves IgE antibodies and other immune cells
For a person with an allergy, the immune system overreacts to the allergen by producing IgE antibodies. The IgE antibody then travels to the cells that release the allergen and cause symptoms in the lungs, nose, throat, or skin.
Each IgE antibody has its own "radar" for each type of trigger. This is why some people are allergic to pollen, others to animal dander, while others may be allergic to many other things. together.
In addition, IgE antibodies also play a very important role in protecting the body against diseases caused by parasites.
2. What is the IgE test for?
IgE test helps to measure the total amount of IgE antibodies in a person's blood by using chemiluminescence technology on automated immune system
IgE test is now used to:
Allergy test for patients . Find out diseases caused by parasites. Diagnosis of multiple myeloma IgE in patients. Usually, IgE antibody levels change with age. Adults will have antibody levels < 100 IU/ml.
The case of increased serum IgE levels may be due to:
The patient has an allergic disease such as: atopic dermatitis, drug allergy, exogenous bronchial asthma, food allergy, hay fever or rhinitis allergy... Suffering from multiple myeloma type IgE. Have pemphigus bullous disease. Have a sinus infection. Having diseases of parasitic infections such as: hookworm, roundworm infection, schistosomiasis or echinococcus infection,... Decreased IgE levels can be caused by:
Congenital IgE antibody deficiency. Suffered from vasodilatation. Have advanced stage carcinoma. The patient does not have gamma globulin in the blood. Have immunodeficiency syndrome (AIDS). Have multiple myeloma that is not of the IgE type.
3. The role of anti-IgE drugs in the treatment of allergic diseases
IgE antibodies play an extremely important role in the pathogenesis of allergic diseases. The association of IgE antibodies with pathogenic antigens helps to kick-start the allergic inflammatory cascade and induce delayed allergic reactions in patients.
Many recent studies have demonstrated that anti-IgE drugs are effective in the treatment of allergic diseases that do not respond to other drugs.
In general, when a person has an allergy, the symptoms will happen very quickly and range from mild to severe, even anaphylaxis if not treated promptly. Therefore, as soon as you see abnormal changes in your body, go to the nearest medical facility for timely examination and treatment.
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