Daivobet ointment for psoriasis treatment

Article by Pharmacist, Master Pham Thi Kim Dung - Pharmacist - Faculty of Pharmacy - Vinmec Times City International Hospital

Daivobet ointment is a treatment for psoriasis with the effect of differentiation and blocking of keratinocytes. Although it is a topical drug, before using it, patients need to know the information about the drug.

The symptoms of psoriasis are caused by an overgrowth of epidermal keratinocytes associated with an immune response disorder, combined with inflammation of the epidermis and dermis of the skin.
Daivobet medicine contains, in 1g of the drug:
Cacipotriol 50 μg (as hydrate 52.2 μg): a substance similar in structure to vitamin D3. The mechanism of action of calcipotriol is by binding to the vitamin D3 receptor, inhibiting keratinocyte proliferation and enhancing keratinocyte differentiation in the skin. Betamethasone 0.5mg (as dipropionate 0.643mg): is a synthetic corticosteroid with anti-inflammatory and immunosuppressive effects.

Topical treatment of common psoriasis in adults
2.1 Contraindication of Daivobet Drugs The drug is contraindicated for people:
Hypersensitivity to the ingredients of the drug Patients with red, scaly and pustular psoriasis Patients disorders of calcium metabolism Patients with: viral skin lesions (eg, herpes, varicella), fungal or bacterial skin infections, parasitic infections, tuberculosis-related skin diseases, perioral dermatitis, skin atrophy, stretch marks, varicose veins of the skin, itching, acne , rosacea, rosacea, ulcers and scars. Patients with severe renal impairment or severe liver failure 2.2 Dosage and administration of Daivobet: Dosage:
Apply the drug to the affected area once a day. The recommended duration of treatment is 4 weeks. If it is necessary to continue or restart treatment after 4 weeks, it is necessary to re-examine and consult a doctor. The maximum daily dose of the drug should not exceed 15g/day If the patient is taking other drugs containing calcipotriol to treat psoriasis, it is necessary to balance the doses of the drugs so that the total amount of calcipotriol in all drugs does not exceed 15g/day. The total body surface area to be treated should not exceed 30%. Daivobet is not recommended for people under 18 years of age.

How to use and some notes:
Wash your hands before and after using the medicine (except in the case of using the medicine to treat the hands). Avoid accidentally spreading to other parts of the body. Avoid applying the medicine in: large damaged areas of skin, skin folds such as the groin, on the vagina, on the face, in the mouth, nose or eyes, avoid a tight bandage after applying the medicine. For optimal effect, it is not recommended to shower immediately after use. During treatment with Daivobet patients should limit or avoid excessive exposure to natural or artificial sunlight. There are not enough safety data on the use of the drug in pregnant or lactating women, consult your doctor before using Daivobet in these patients.

Adverse reactions that patients may experience during the use of Daivobet ointment such as:
Topical reactions: Itching, skin irritation, burning sensation, tingling, dry skin, skin redness , dermatitis, eczema, exacerbation of psoriasis, photosensitivity, angioedema. Long-term reactions related to betamethasone, corticosteroids in the drug, including: skin atrophy, capillary dilation, stretch marks, folliculitis, hyperpigmentation, perioral dermatitis, allergic contact dermatitis, loss of coloration good, colloidal millet. Overdose can lead to hypercalcemia. Common symptoms include: constipation, muscle weakness and coma. These symptoms will subside quickly when the drug is stopped. Patients should stop taking the drug and notify the doctor when experiencing side effects of the drug.

Above is important information about Daivobet ointment, patients need to read the instructions carefully before using and it is necessary to consult a doctor, pharmacist to have appropriate indications for each condition. sick.