How is Daivonex ointment used to treat psoriasis?

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Article by Pharmacist, Master Pham Thi Kim Dung - Pharmacist - Faculty of Pharmacy - Vinmec Times City International Hospital

Daivonex Ointment is a psoriasis medication that is prescribed by doctors for the topical treatment of mild psoriasis and plaque psoriasis. To get the best results, patients need to strictly follow the instructions of the doctor or pharmacist.

1. Composition and uses of Daivonex ointment

The symptoms of psoriasis are caused by an overgrowth of epidermal keratinocytes associated with an immune response disorder, combined with inflammation of the epidermis and dermis of the skin. Accordingly, doctors often appoint patients to use Daivonex ointment in cases where the patient's level is normal and mild.
In 1g of the drug Daivonex contains: Cacipotriol 50 μg (as anhydrous). This is a substance similar in structure to vitamin D3. The mechanism of action of calcipotriol is by binding to the vitamin D3 receptor, inhibiting keratinocyte proliferation and enhancing keratinocyte differentiation in the skin. Therefore, the drug has the effect of reducing the thickness, scale, erythema and size of psoriasis.

2. Indications and contraindications to the use of ointment Daivonex

2.1. Indications for the treatment of Daivonex

Daivonex Ointment is indicated for the topical treatment of mild psoriasis and psoriasis.

2.1. Contraindications of the drug Daivonex

Daivonex is contraindicated in the following patients:
Hypersensitivity to the drug's components Patients with known calcium metabolism disorders See now: Psoriasis treatments are being personalized

3. Dosage and how to take Daivonex

3.1. Dosage

In adults:
Apply the medicine directly to the affected area 1-2 times a day. Patients should take the drug twice a day to increase the effectiveness of the treatment. The maximum dose of Daivonex for adults should not exceed 100g/week. If the patient is taking other drugs that also contain calcipotriol, the total dose of all drugs, including Daivonex, should be balanced to not exceed 5 mg of calcipotriol/week. In children:
Over 12 years old: The drug should be used twice a day with a dose not exceeding 75g/week. From 6 to 12 years old: The drug should be used twice a day with the maximum allowable dose of 50g. Children under 6 years of age: There are no data on the safety of use in this age group. For pregnant and lactating women when using Daivonex, it is necessary to consult a doctor when using the drug.

3.2. How to take Daivonex

Drug users need to wash their hands before and after using the medicine (except in the case of using the medicine to treat the hands). Avoid accidentally spreading to other parts of the body. In addition, for optimal effect, it is recommended that patients do not shower immediately after use.

4. Notes when using Daivonex to treat psoriasis

In the process of using Daivonex psoriasis medication, it should be noted:
Daivonex ointment is safe to use for up to 8 weeks. After 2-8 weeks of using the drug, if the signs of psoriasis do not improve or show signs of worsening, the patient should stop using the drug and consult a doctor for specific advice. Do not exceed the recommended dose above. Daivonex should not be used on the face Medicines containing propylene glycol as an excipient can cause skin irritation, especially if used in large amounts. If the patient is being treated with more than one topical medication at the same time, avoid topical acids with Daivonex, because the calcipotriol component is susceptible to inactivation (eg, salicylic acid, lactic acid, preparations containing hydrocortisone valerate). Consider applying these medications 10-12 hours apart from Daivonex to reduce drug interactions. During treatment with Daivonex patients should limit or avoid excessive exposure to natural or artificial sunlight.

5. Possible adverse reactions when using Daivonex ointment

Possible adverse reactions when using Daivonex ointment:
Topical effects: itching, skin irritation and erythema. Overdose may lead to hypercalcemia. Common symptoms include: constipation, muscle weakness and coma. These symptoms will subside quickly when the drug is stopped. In addition, other undesirable effects may be encountered such as: folliculitis, exacerbation of psoriasis or dermatitis, erythema, peeling, ....
Daivonex ointment is a treatment for psoriasis prescribed by doctors in moderate and mild cases. To ensure the effectiveness of treatment, patients need to take medicine according to prescription or under the direction of a doctor or pharmacist.

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This article is written for readers from Sài Gòn, Hà Nội, Hồ Chí Minh, Phú Quốc, Nha Trang, Hạ Long, Hải Phòng, Đà Nẵng.