Uses of Arfloquine

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Arfloquine belongs to the group of anti-parasitic, anti-infective, anti-viral, anti-fungal drugs, effective in treating acute malaria, helping to cut fever quickly and prevent recurrence. Arfloquine is a medicine to be used under the direction of a doctor.

1. What is Arfloquine?

Arfloquin medicine has the main active ingredients Artesunate, Mefloquine and other excipients just enough. The drug is prepared in the form of long tablets or film-coated tablets, packed in boxes, one box includes 1 blister of 3 Artesunate long tablets and 3 Mefloquine film-coated tablets.

2. Uses of Arfloquine

Mechanism of action:
Active ingredient Artesunat is a medicinal herb traditionally used to treat malaria in China. Active ingredient Mefloquine is a cytotoxic drug of the malaria parasite, effective against P. falciparum sensitive and resistant to Chloroquine as well as strains resistant to many other drugs. The combination of these two active ingredients increases the effectiveness in the treatment of patients infected with P. falciparum, helps to reduce the infection and slows down drug resistance.

2.1. Use - Indication

Arfloquin medicine is indicated for use in cases of acute uncomplicated malaria caused by the bacterium Plasmodium Falciparum, to help cut fever quickly and help prevent recurrence.

2.2. Contraindications

Arfloquine is contraindicated for use in the following cases:
People who are allergic or sensitive to the components Artesunate, Mefloquine contained in the drug. Children and people whose physical weight is less than 30kg. Women who are pregnant or are breastfeeding. People with a history of mental illness, epilepsy, severe liver or kidney failure. People with cardiovascular diseases. Note: Cases of contraindication to Arfloquine should be understood as absolute contraindications, that is, not for any reason that these cases should be flexible to use the drug, to avoid causing adverse effects. unfortunate results.

3. How to use and dose Arfloquin

How to use: Arfloquin medicine is prepared in the form of long tablets and film-coated tablets should be taken orally directly, combined with a sufficient amount of water, used with meals. Do not crush or break the tablet during oral administration so as not to affect the ingredients in Arfloquin.
Dosage: Recommended dose: Use 2 pills at the same time, including: 1 Artesunat 200mg tablet and 1 Mefloquin 250mg tablet, taken once a day, used continuously for 3 days.
In case of missed dose: Take the dose as soon as you remember and use the next dose after 24 hours. Never use two doses in a row for less than 24 hours.
In case of overdose: Currently, there are not enough research reports showing the symptoms that occur when using an overdose of Arfloquine. However, if you discover that you have overdosed and appear unusual symptoms, you should immediately contact your doctor and specify the amount of Arfloquin drug used, your current condition to get it. Best advice on how to handle.

4. Arfloquine side effects

During the use of the drug, in addition to the main use that Arfloquin brings, users may also experience some unwanted symptoms as follows:
Common side effects: Dizziness, headache, somnolence nodding, insomnia, balance disorder, nausea, vomiting, abdominal pain, diarrhea,...
Note : If the above symptoms appear or any other symptoms are suspected to be caused by taking the drug, the person Patients should stop using Arfloquin immediately and inform their doctor about their condition.

5. Interactions with Arfloquine

Users should keep in mind some interactions between Arfloquine with other drugs as follows:
Avoid combining Arfloquin with substances with Antioxidant effects such as vitamin C, vitamin E, Glutathione, ... because it will reduce the antimalarial effect of the drug. Caution should be exercised when administering the drug to patients taking calcium channel blockers, beta blockers, digitalis, or antidepressants. Absolutely do not use Propranolol in combination with drugs because there have been cases of cardiac arrest - respiratory arrest when using only 1 dose while taking Propranolol. Arfloquine will increase the heart effect of other antimalarial drugs such as Quinidine or Quinine. Concomitant use with Primaquin may result in a higher incidence of adverse events occurring with Arfloquine. Concomitant use with Valproic Acid will reduce the concentration of Valproate in the serum. Note: In order to minimize the negative interactions between drugs, patients need to inform their doctor or pharmacist what drugs or functional foods they are using or intend to use with them. Arfloquin for advice on the best course of treatment.

6. Some notes when using Arfloquine

Before and while using Arfloquin, users should note a few things:
The drug should not be used by patients who are sensitive or allergic to the active ingredient Mefloquine or sensitive to substances with related structures. such as Quinine, Quinidine, and Chloroquine. Do not use combination drugs with Quinine, only after stopping using Quinine for at least 12 hours. Avoid becoming pregnant while using Arfloquine and for about 3 months after taking it. Only use Arfloquin for women who are breastfeeding when absolutely necessary, when the benefit of the drug is many times higher than the harm that the mother or baby may experience. Care should be taken when using the drug for people who are driving a vehicle, boat or operating machinery. Hopefully, the information shared above about the drug Arfloquin will help users equip themselves with more knowledge and skills in using the drug to treat malaria. Note that Arfloquin is a prescription drug, so patients should not use it on their own, but need to contact a doctor/pharmacist directly to get a suitable prescription and ensure safety for health.

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