Uses of Aronol

Aronol is an injectable drug with a capacity of 1ml/tube with the main active ingredient being tramadol 50mg. Medications are usually prescribed to relieve moderate to severe pain. The following article will help you understand what Aronol is, its uses, indications as well as other useful information related to the drug.

The active ingredient tramadol contained in the drug Aronol is an opioid pain reliever, with the same addictive potential as morphine. When administered to the body, tramadol and its metabolites bind to receptors on neurons to block the re-entry of the neurotransmitters serotonin and norepinephrine, resulting in a reduction in symptoms. pain.
Another difference between tramadol and morphine is that tramadol does not cause histamine release, so it does not have much effect on heart rate and left ventricular function, and also has less respiratory depression than morphine.
With the above mechanism, Aronol is usually prescribed for the following purposes:
Relief of moderate to severe pain (including acute and chronic pain) such as: postoperative pain, cancer pain pain, visceral pain,... Cases of pain that are intolerant or responsive to other analgesics.

Aronol usually begins to work after about 1 hour of taking the drug, the dose of Aronol depends on the nature and severity of pain in each patient.
For acute pain:
Usually a dose of 50-100mg is given by slow intravenous injection (from 2 to 3 minutes) or by infusion. Repeat every 4 to 6 hours. The maximum total dose is 400mg/day. Particularly for postoperative pain relief, the first dose is usually 100mg, then a dose of 50mg every 10-20 minutes, but the total dose in the first hour should not exceed 250mg (including the starting dose). head). Then, every 4-6 hours, a dose of 50-100mg will be used, the maximum total dose should not exceed 600mg/day. For chronic pain:
The feature of chronic pain relief is that it does not require rapid action and usually requires long-term administration, so the dose of Aronol is usually started at a low level then gradually increase the dose over time. The recommended starting dose is 25 mg/day, then increased by 25 mg every 3 days until a dose of 100 mg/day is reached. If there is still no response to the patient's pain, continue to increase the dose every 3 days, in 50mg increments but the maximum total dose per day should not exceed 400mg. The daily dose should be divided into doses, from 50-100mg/time, every 4-6 hours. Aronol is an injectable drug, prescribed as a drug with special control, so patients must strictly adhere to the treatment as directed by the doctor.

Aronol is not indicated for the following subjects:
Patients with respiratory failure Patients with uncontrolled epilepsy People who are being poisoned with CNS depressants such as sleeping pills, alcohol, drugs Other opioids, psychotropic drugs, etc. Patient is on MAOI treatment or has stopped taking MAOI for less than 15 days Pregnant patient Under 15 years old Patient has a history of hypersensitivity or addiction to opioids

Patients treated with Aronol may experience undesirable symptoms such as:
General discomfort Abdominal pain, bloating, anorexia, taste disturbances Gastrointestinal ulcers Increased muscle and bone tone restlessness, insomnia, anxiety Lower blood pressure, heart palpitations Urinary retention, urinary incontinence, menstrual disturbances Allergic reactions such as rash, skin rashes Increased liver enzymes, increased proteinuria, adverse effects to liver and kidney function The longer the duration of taking Aronol, the higher the dose, the greater the incidence of side effects, and also the severity of these undesirable symptoms.

If high doses of Aronol are used for a long time, it can cause an addiction syndrome similar to morphine, which manifests in the patient's craving, seeking or drug addiction. Therefore, caution should be exercised in patients with a history of opioid addiction. When stopping Aronol suddenly after a prolonged period of use, patients may experience withdrawal syndrome with symptoms such as sweating, restlessness, panic, hair standing, insomnia, diarrhea. You may even experience hallucinations and paranoia. Therefore, treatment should be started from the lowest dose, minimized the duration of drug use and if necessary, the dose should be reduced gradually, avoiding abrupt discontinuation. If Aronol is taken with alcohol or other anesthetics, the patient may be at increased risk of respiratory depression. Therefore, caution should be exercised when having these combinations. In therapeutic doses, Aronol can cause seizures, which is very dangerous for patients with a history of epilepsy or who are taking antidepressants. Aronol should be used with caution in patients with a history of anaphylaxis with other opioids. Careful monitoring of treatment is required when administering Aronol to patients with head trauma or increased cranial pressure because of the relatively high risk of the drug affecting mental status in these subjects. Dosage adjustment of Aronol is required in patients with severely impaired hepatic or renal function.
The treatment with Aronol can reduce alertness, cause symptoms of blurred vision for patients, so patients should limit driving, operating machinery while taking the drug. In animal studies, the active ingredient tramadol contained in Aronol has the ability to cross the placenta and cause toxicity to the animal fetus, the drug also has the ability to cross the milk ducts, thereby minimizing the use of Aronol. for patients who are pregnant or breastfeeding. An overdose of Arono l can lead to extremely serious consequences, there have been cases of death when an overdose of the active ingredient tramadol has been reported. The most common manifestations of Aronol overdose are tachycardia, vomiting, convulsions, respiratory failure and possibly coma. If a patient overdoses on Aronol, it should be quickly taken to a medical facility for timely intervention.

Some drug interactions can occur when Aronol is used concurrently with the following drugs:
Carbamazepine reduces the effect of Aronol by increasing drug metabolism. If two drugs are combined, the dose of Aronol should be increased to ensure treatment. Fluoxetine, amitriptyline: There is an antagonistic effect to Aronol, so do not combine Aronol with these drugs. Quinidine: Increases the effects of Aronol by reducing drug metabolism through inhibition of CYP2D6. Use caution because of the increased risk of Aronol overdose. Warfarin: Taking Aronol and warfarin together can affect the blood clotting time of the body.