Uses of Audogyl

Audogyl is known as a drug manufactured by Gia Nguyen pharmaceutical joint stock company with the use of treating bacterial infections in the oral cavity, the drug is a combination of 2 main active ingredients, Spiramycin and Metronidazol.
Each Audogyl film coated tablet is formulated with the following ingredients:
Spiramycin (750,000 IU) Metronidazol (125mg) Other excipients (including microcrystalline cellulose, starch from corn, titanium dioxide, povidone k30, magnesium stearate, talc, hydroxypropyl...) with sufficient content as specified by the manufacturer.
Audogyl is available only in the form of film coated tablets

2.1 Effects Audogyl tablets are a combination of 2 main active ingredients, Spiramycin and Metronidazol, so they have the following pharmacological effects:
Spiramycin: this is an antibiotic belonging to the Macrolide group. Depending on the concentration of the drug in the tissue and in the serum, the effect of the active ingredient will vary from inhibiting bacteria to killing bacteria. The drug is especially effective on bacteria that are in the stage of cell division. Its effect is shown by binding to the 50S ribosomal subunit, inhibiting the protein synthesis of bacterial cells, making bacterial strains unable to grow. The action spectrum of the drug is shown on Gram-positive bacteria strains, Coccus strains such as Pneumococcus, staphylococcus,...; strains of bordetella pertussis, corynebacteria... and had no effect on Gram-negative bacteria. Metronidazole: is an antibiotic of the Imidazol group with broad spectrum activity including parasites, amoeba, giardia, even anaerobic bacteria. The chemical structure of this substance includes a 5-nitro group, when entering the bacterial cell, it will transform into a toxic substance for bacterial cells by the mechanism of attaching to the twisted structure of DNA, causing damage to this structure. As a result, the bacteria die. The combination of these two compounds in one Audogyl tablet is extremely important, not only increasing the antibacterial activity of both active ingredients, but also helping to reduce the concentration of each substance in the drug, avoiding the risks. risk of overdose or increased undesirable effects.
2.2 Indications Audogyl is prescribed by many doctors when they want to treat bacterial infections, infections in the teeth and mouth, including acute and chronic including tooth abscess, gingivitis; inflammation, swelling of gums, roots of teeth; inflammation of the cells around the jawbone site; gingivitis ; periodontitis ; under the jaw or inflammation of the gland in the parotid position,... In addition, the drug is also used to prevent bacterial infections after undergoing an oral surgery.
2.3 How to use – Dosage How to use: Audogyl is an oral drug, you should take it with meals, take it with filtered water, do not take it with milk, tea or any other drink. There is no need to bite, chew or crush the tablet.
Dosage: Depending on the user, the dose of the drug may change. Recommended dosage is:
Adults: Usual dose: 2 to 3 times a day, 2 tablets each time. Attack dose: (used when patients have severe infections) double the dose, take 2 times a day, 4 tablets each time. Children from 10-15 years old: 3 times a day with meals, 1 tablet each time. Children from 6-10 years old: take 2 times a day, 1 tablet each time, can be taken in the morning and evening. You should consult your doctor before using the drug for the safest and most effective use.
2.4 How to handle overdose, forget dose of Audogyl When using an overdose of Audogyl, it can cause digestive disorders: nausea, vomiting, abdominal pain; inability to regulate the body; more severe cases can affect the nervous system such as convulsions ; neuritis,...
Immediately seek medical assistance if overdose is suspected.
It is necessary to have reminders to always adhere to the medication prescribed by the doctor.
You must not miss doses or stop taking treatment because Audogyl is an antibiotic, if treatment is not definitive, it can increase the risk of antibiotic-resistant bacteria, reducing the effectiveness of treatment.
If you miss a dose, you need to take a supplement immediately, do not let the time of taking 2 doses be too close, if the time of taking is too close, you can skip the missed dose and use the next dose. Consult your doctor for more detailed information on treatments.

The most common side effects when using Audogyl are nausea, vomiting, digestive disorders, abdominal pain, bloating, indigestion, loose stools, sometimes a metallic taste in the mouth.
In addition, in some cases the patient may also experience itching, rash, urticaria; fatigue, headache; Decreased white blood cell count, nosebleeds, excessive sweating...
If you experience any strange signs during the use of the drug, you should immediately see a doctor for timely support measures such as changes. dose or change the treatment so that it is safest and most effective.

Contraindications:
Audogyl should not be used by people who are allergic to Spiramycin, Metronidazol or any other excipients.
Do not use Audogyl for children under 6 years old and pregnant women, especially women in the first 3 months of pregnancy. In addition, the drug should not be used by women who are breastfeeding.
Caution:
Care should be taken when using the drug in patients with liver and kidney failure. When using the drug, patients with liver and kidney failure may experience hot flushes, nausea, vomiting or mild headache; sometimes even abdominal cramps and sweating, because metronidazole acts on enzymes that hydrolyze or oxidize alcohols such as dehydrogenase.
If you use high doses or long-term treatment with Audogyl, it can also cause blood biochemical disorders; mild neurological disorder.
Spiramycin and Metronidazol both have the ability to cross the placenta and be excreted in breast milk. Although Spiramycin does not have a great effect on the baby, Metronidazol has been studied as a potentially teratogenic substance, so you should not use it if you are pregnant or breast-feeding.
The drug can cause headaches (although very rarely) but you should still use caution when using Audogyl while driving or operating machinery.

Note when using with other drugs
Audogyl should not be used with oral contraceptives, including daily or emergency contraceptive pills, because it can make the drug ineffective. Audogyl when used with anticoagulants can also increase the effect of anticoagulants, so they should not be used with these drugs. In addition, if you take Audogyl with Phenobarbital drugs, it can make Audogyl clear from the body faster. In particular, during the use of Audogyl, you must not use alcohol and other alcoholic beverages.