This is an automatically translated article.
Baxmune 500 belongs to the group of anti-cancer drugs and acts on the immune system. The drug is often indicated in the prevention of rejection reactions in patients receiving allogeneic renal transplantation. Follow the article to better understand Baxmune 500 and its uses.
1. What is Baxmune 500?
Baxmune 500 is an anti-cancer drug and acts on the immune system. Baxmune 500 is available as a film-coated tablet. 1 blister of 10 tablets.
Drug ingredients:
Mycophenolate mofetil 500mg: Mycophenolate Mofetil is an inhibitor of T and B Lymphocytes because Mycophenolate Mofeti inhibits the enzyme Inosine monophosphate dehydrogenase, has a central position in the synthesis of purines. Some other active ingredients and excipients in the drug: Microcrystalline Cellulose, Povidone, Croscarmellose Sodium, Talc, Colloidal Anhydrous Silica, Magnesium Stearate just enough for 1 tablet.
2. When to assign Baxmune 500?
Indications for the use of Baxmune in the prevention of rejection reactions occurring in patients after performing renal, heart, and allogeneic liver transplantation in combination with cyclosporine & corticosteroids.
3. How to use, dosage Baxmune 500
Baxmune 500 with the main ingredient is Mycophenolate Mofetil, so the dosage and maintenance will be decided by the treating doctor based on the age and condition of each patient.
3.1 Use in Kidney Transplant Adults: Take Baxmune 500 orally within 72 hours of the transplant.
For kidney transplant patients: use 1g, take 2 times a day (ie 2g a day). If increased immunosuppression is required, the doctor may increase it to 3g/day. Children and adolescents (ages 2 to 18 years): Use 600mg/m2 orally. Drink 2 times / day (maximum 2g 1 day).
Children and adolescents may experience more side effects than adults. If side effects occur, it is necessary to reduce the dose temporarily or discontinue the drug.
Children under 2 years: According to research, children under 2 years old are not recommended to use Baxmune 500 to ensure safety for young children.
Prophylaxis of transplant rejection: The dose is 2g/day.
Severe renal impairment (filterability < 25 mL/min/1.73 m2) should not be used in doses higher than 1g after the transplant surgery period. In patients with slow-functioning grafts, the dose of the drug should be adjusted accordingly.
3.2 Use in Heart Transplants Adults: Take Baxmune 500 orally to initiate therapy within 5 days of a heart transplant performed. The recommended dose for heart transplant patients is 1.5 g twice daily (maximum 3 g per day).
Children: There is no exact dose for pediatric heart transplant patients.
3.3 Use in Liver Transplants Adults: Take Baxmune 500 intravenously within 4 days after liver transplant surgery.
With oral Baxmune 500, patients will need to take it soon after transplantation to avoid drug tolerance. The recommended dose in patients after liver transplantation is 1.5 g once, orally twice a day (maximum 3 g per day).
Children: There is no exact dose for pediatric liver transplant patients.
Use in people 65 years of age and older: The recommended dose is 1g once, taken twice a day for kidney transplant patients and 1.5g once, taken twice a day for post-transplant patients. heart or liver transplant.
4. When is Baxmune 500 contraindicated?
Baxmune 500 is contraindicated in patients with hypersensitivity to the mycophenolate component or mycophenolic acid.
Women who are breastfeeding
Drug interactions:
Do not use Baxmune 500 with azathioprine.
Use caution when taking Baxmune 500 with acyclovir, antacids, cholestyramine, probenecid, drugs excreted by the renal tubules.
5. Baxmune 500 . side effects
During treatment with Baxmune 500 may cause the following undesirable reactions:
Diarrhea, leukopenia, sepsis, vomiting. In addition, some infections may occur with a high frequency. You should notify your doctor and stop taking the drug if any of the above allergic reactions occur.
6. Dealing with missed dose or overdose
Missed dose: If you forget to take a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take double the prescribed dose.
Overdose: If there are abnormal symptoms when overdose, it is necessary to immediately notify the doctor or medical person for timely handling.
7. Store Baxmune 500 Properly
Store in a cool, dry place, avoid direct light, below 30 degrees C.
Keep out of reach of children and pets.
Once you understand the use of Baxmune 500, patients should strictly follow the principles of drug use to get the best effect when treating the disease.
