Uses of Phloroglucinol

Phloroglucinol is used for the symptomatic treatment of pain caused by dysfunction of the gastrointestinal tract, biliary tract, urinary tract, and uterine pain.

Phloroglucinol is an gastrointestinal drug with antispasmodic effects, used in the following cases:
Symptomatic treatment of pain associated with dysfunction of the digestive system and biliary tract; Treatment of acute pain caused by urinary tract spasm: Renal colic ; Symptomatic treatment of pain caused by spasms in gynecology; Supportive treatment of contractions during pregnancy combined with convalescence. Contraindications Phloroglucinol:
Phloroglucinol is contraindicated in patients with a history of hypersensitivity to the components of the drug, functional bowel paralysis, intestinal obstruction. Drug form:
Film-coated tablets; Injection solution; Injections. Pharmacodynamics (Mechanism of action):
Phloroglucinol directly inhibits voltage-dependent calcium channels on smooth muscle cells, leading to an antispasmodic effect on smooth muscle and against visceral pain, especially in acute pain. Pharmacokinetics:
Absorption: The drug is rapidly and extensively absorbed after oral administration. Peak plasma concentrations are reached about 15-20 minutes after oral administration. The extent of absorption is dose dependent and unaffected by food. Metabolism: The drug is metabolised in the liver by glucuronidation. Distribution: There are no data showing that the drug is distributed into body tissues or crosses the blood-brain barrier. Elimination: The drug is excreted mainly by the kidneys as glucuronide conjugates and to a small extent in the faeces as free and conjugated forms. The half-life is approximately 1 hour 40 minutes.

Dosage in adults:
Oral medicine: Take 2 tablets of 80mg at pain. Take 2 more tablets if still having a lot of spasms. Up to 3 times a day (6 tablets in total); Sublingual medication: 1 tablet each time, up to 3 tablets/day, at least 2 hours apart between each dose; Injection: Initial dose: 1-3 ampoules/day, intravenously or intramuscularly. Maintenance dose: Switch to oral form with a maximum dose of 6 tablets / day or suppository 3 tablets / day. Dosage in children:
Children 12 years and older: Take 1 tablet of 80 mg x 2 times / day; Children over 2 years: The usual dose is 1 tablet of 80 mg, taken at the time of pain and can be repeated in case of severe spasms, at least 2 hours between each dose. The maximum dose should not exceed 2 tablets every 24 hours.

This drug very rarely causes serious allergic side effects, however patients still need to monitor the body for side effects when taking the drug such as urticaria, rash, Quincke's edema, hypotension. arterial pressure h , can even lead to drug shock to promptly contact a doctor.
Common side effects: Patients will often experience a common side effect is rash; Rare side effects: Urticaria, angioedema, hypotension, anaphylaxis; Frequency not determined: Red scaly rash with subcutaneous masses and vesicles with fever at the start of treatment (acute generalized exanthematous pustules). 4. Notes when using Phloroglucinol General note: Patients should not combine Phloroglucinol with drugs or medicinal herbs containing Morphine compounds and derivatives because they have antagonizing antispasmodic effects, reducing the effect of Phloroglucinol . Caution to pregnant women: Animal studies have not demonstrated any teratogenic effects of Phloroglucinol. To date, the relatively widespread use of Phloroglucinol in clinical practice has not demonstrated any teratogenic risk. However, epidemiological studies are needed to determine that there are no risks associated with the use of Phloroglucinol. Therefore, Phloroglucinol should be used during pregnancy only when absolutely necessary, as prescribed by your doctor. Caution for nursing women: Because there are insufficient safety data, this drug should not be used in nursing women. Precautions while driving and using machines: There is no or negligible effect on the ability to drive and use machines. 5. Management of overdosage and missed dose Phloroglucinol Overdose and toxicity:
Cases of overdose have been reported without specific symptoms. How to handle overdose: The patient should be taken immediately to the nearest medical facility for timely treatment. Missed dose and treatment:
If a dose is forgotten, the patient should take it as soon as he remembers. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take twice the prescribed dose. In general, Phloroglucinol is used for the symptomatic treatment of painful manifestations due to dysfunction of the gastrointestinal tract, biliary tract, urinary tract, and uterine pain. Store the medicine at a temperature not exceeding 30 degrees Celsius, avoid direct light and store too humid during use.