Uses of Rofcal

Rofcal is on the World Health Organization's list of essential medicines, used as a medicine to treat low blood calcium caused by hypoparathyroidism, osteomalacia and hyperparathyroidism due to kidney disease, osteoporosis, and hypophosphataemia.

Rofcal has the main ingredient is Calcitriol 0.25mcg, the drug is indicated for use in the treatment of diseases such as:
Treatment of hypothyroidism (after surgery, hypothyroidism). Treatment of hypocalcaemia - hypoparathyroidism, osteomalacia (adults), rickets (infants, children), renal osteodystrophy or chronic kidney disease. Treatment of chronic renal failure (especially for patients treated with hemodialysis or renal osteodystrophy). Treatment of osteoporosis and prevention of corticosteroid-induced osteoporosis Calcitriol is also used to treat psoriasis and psoriatic arthritis. Mechanism of action: Calcitriol ingredient has the ability to increase blood calcium levels through promoting calcium absorption from the gastrointestinal tract, increasing calcium reabsorption in the renal tubules, thereby reducing urinary calcium loss. , stimulates calcium release from bone.

How to use: The drug is prepared in the form of film-coated tablets and used orally.
Dosage:
The doctor will give the patient a dose of the drug based on the serum calcium concentration of each patient. During treatment with the drug, patients should have their serum calcium levels tested at least twice a week. If the patient has a hypercalcemia syndrome, it is necessary to stop taking the drug to allow the serum calcium concentration to return to normal.
In the treatment of renal osteodystrophy: The recommended starting dose is 1 tablet/day. In the case of patients with normal or slightly decreased calcium levels, it may be necessary to use only 1 tablet, twice a day. Treatment of hypothyroidism, rickets, osteomalacia: Apply the starting dose of 1 tablet/day in the morning, then the patient can increase the dose within 2-4 weeks, if there is no reaction. positive on biological testing and no clinical symptoms. In the prevention and treatment of osteoporosis: Use 1 tablet, 2 times a day. If the therapeutic effect is not achieved, the dose can be increased to 2 tablets per day, taken twice a day and used for 1 month. Contraindications
Do not use the drug in patients with disorders associated with increased serum calcium levels. The patient is hypersensitive to the Calcitriol component of the drug. Do not use with patients with symptoms of vitamin D toxicity Calcitriol should not be used if the body has high levels of calcium or vitamin D in the blood.

If using high doses of Rofcal may cause unwanted side effects such as: Hypercalcemia syndrome or calcium toxicity, depending on the degree and duration of hypercalcemia.
Chronic side effects: Dystrophy, paresthesia, fever with thirst, increased urine, dehydration, depression, urinary tract infection.
Acute side effects: Loss of appetite, headache, vomiting, constipation. In patients with normal renal function, when serum calcium concentration is increased and the drug is used for a long time, an increase in serum creatinine concentration may occur.
Other possible serious side effects are high blood calcium levels and anaphylaxis. Therefore, patients should have regular blood tests after starting treatment with the drug and when changing the dosage.

Use caution when administering Rofcal to patients with a history of kidney stones or coronary artery disease.
For pregnant and lactating women, children under 3 years of age, and children being treated with hemodialysis: There is not enough evidence to prove the safety of Rofcal for all cases. above case. Therefore, patients need to be especially careful when using it and consult a qualified doctor.

Possible Rofcal drug interactions during use are as follows:
Abametapir: The serum concentration of Calcitriol may be increased when it is combined with Abametapir. When used with anticonvulsants, cholestyramine, colestipol, cortisone, neomysin, phenobarbital, rifampin, neomycin: These drugs may reduce the effect of Rofcal. Taking Rofcal in combination with antacids may cause magnesium excess. Taking Rofcal in combination with digitalis preparations may cause cardiac arrhythmias. Taking Rofcal in combination with diuretics may cause hypercalcemia. Taking Rofcal in combination with preparations containing phosphate may increase the accumulation of excess phosphate. Abemaciclib, Albendazole, Acalabrutinib, Acenocoumarol: The metabolism of the above drugs may be increased when combined with Calcitriol Acetyldigitoxin: The risk or severity of ventricular arrhythmias and arrhythmias may be increased when Calcitriol is given. in combination with Acetyldigitoxin Aluminum hydroxide: Serum aluminum hydroxide concentration may be increased when it is combined with Calcitriol Beclomethasone dipropionate: The therapeutic efficacy of Calcitriol may be decreased when used in combination with Beclomethasone dipropionate Bendroflumethiazide: Risk or level The severity of hypercalcaemia may be increased when Bendroflumethiazide is combined with Calcitriol Betamethasone: Therapeutic efficacy of Calcitriol may be decreased when used in combination with Betamethasone Calcium acetate, Calcifediol: Risk or severity of side effects Adverse effects may be increased when Calcitriol is combined with the above drug. Rofcal contains Calcitriol as the main ingredient. The drug is indicated for use in the treatment of many different diseases. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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