Causes of elevated liver enzymes

The article is professionally consulted by Master, Doctor Vu Huy Binh - Department of Medical Examination & Internal Medicine - Vinmec Hai Phong International General Hospital.

Liver enzymes are only enzymes that the test team evaluates inflammatory damage and destruction of liver parenchyma towards, including common enzymes in the liver such as:
Alanine aminotransferase - ALT (also known as serum glutamic pyruvic transaminase - SGPT) ), and aspartate aminotransferase - AST (also known as serum glutamic oxaloacetic transaminase - SGOT): These two enzymes belong to the group of transaminase enzymes (also known as aminotransferases). The transaminase group includes intracellular enzymes, present in the cells of many different organs, in which alanine aminotransferase is most abundant in liver cells (in addition, it is also present in kidney and skeletal muscle cells), and aspartate aminotransferase found in liver cells, skeletal muscle cells, cardiac muscle, red blood cells, pancreas, lung and brain. Alkaline phosphatase - AP (alkaline phosphatase): Alkaline phosphatase belongs to the group of enzymes involved in zinc metabolism, which is considered an indicator of cholestatic liver injury. Alkaline phosphatase is present in the biliary tract and hepatic vascular sinuses, and is also present in the bones, kidneys, intestines and placenta. Gamma glutamine transpeptidase - GGT (or abbreviated as γ - GT, Gamma GT): Gamma glutamin transpeptidase belongs to the group of glyco-membrane protein complex structures, responsible for catalyzing, converting gamma glutamyl groups into peptide and amino chains. acid and water. Compared with many other enzymes, the sensitivity of gamma glutamine transpeptidase is very high, changes in the concentration of gamma glutamine transpeptidase in the blood manifest very early. Gamma glutamine transpeptidase is present in the liver (including the endothelial network of biliary cells), kidney, pancreas, intestine, and prostate, so gamma glutamine transpeptidase is also valuable when evaluating cholestatic injury (although although not specific for alkaline phosphatase).

Elevated liver enzymes (usually the enzymes mentioned above) are when their blood levels rise above the normal range. Elevated liver enzymes are detected through blood tests, and elevated levels of liver enzymes in the blood are a warning sign of ongoing liver damage.

There are many different diseases and conditions that lead to elevated liver enzymes. To determine the exact cause, your doctor will need to take your medical history, medical history, medications you are taking, signs and symptoms, and prescribe some necessary techniques or laboratory tests.
Common causes of elevated liver enzymes include:
Over-the-counter medicines, especially those containing acetaminophen (such as Tylenol, Panadol,...). Certain medications require a prescription, including statins used to control cholesterol levels. Drinking alcohol, especially those who drink a lot of alcohol, abuse alcohol. Heart failure . Hepatitis A virus Hepatitis B virus. Hepatitis C virus. Non-alcoholic fatty liver disease. Fat . Alcoholic hepatitis (a severe inflammation of the liver caused by excessive alcohol consumption).

Autoimmune hepatitis (inflammation of the liver related to a disorder of the immune system). Celiac disease. Cytomegalovirus (CMV) infection. Epstein-Barr virus infection. Hemochromatosis (Hemochromatosis). Liver Cancer . Mononucleosis (mononucleosis). Polymyositis (polymyositis). Sepsis. Disorders related to the thyroid gland. Inflammation of the liver due to toxicity. Wilson's disease. Elevated liver enzymes can be a sign of a serious medical condition in the liver, but signs of high liver enzymes often have no obvious symptoms, the simplest way to determine is to check through tests. liver enzymes, blood tests. You can get these tests done during your yearly check-ups.
Periodic health check-ups help to detect diseases early so that there is a treatment plan for optimal results. Currently, Vinmec Central Park International General Hospital has general health checkup packages suitable for each age, gender and individual needs of customers with a reasonable price policy, including: Diamond Health Checkup Package Vip General Health Checkup Package Special Health Checkup Package Comprehensive Health Checkup Package Standard General Health Checkup Package Included in these packages are liver enzyme tests, assessment Assess liver enzyme status and detect liver diseases early. The results of the patient's examination will be returned to the patient's home. After receiving the results of the general health examination, if you detect diseases that require intensive examination and treatment, you can use services from other specialties right at the Hospital with quality treatment and services. outstanding customer service.

Article referenced source: mayoclinic.org