Uses of Fedratinib

Fedratinib is a prescription medicine used in the treatment of certain cancers. So what does Fedratinib do and how is it used?

Fedratinib is a type of targeted therapy called a kinase inhibitor. Kinase is an enzyme that promotes cell growth. There are different types of kinases involved in controlling different stages of cell development.
By blocking a specific enzyme from working, the drug Fedratinib can slow the growth of cancer cells. Fedratinib targets Janus Associated Kinase 2, (JAK2) and FMS-like tyrosine kinase 3 (FLT3).

Fedratinib is made in the form of tablets for oral administration. The dose and how often you take Fedratinib will be determined by your doctor. Swallow the Fedratinib tablet whole; Do not chew, crush or break the tablet.
Fedratinib can be taken with or without food, but taking it with a high-fat meal may reduce the risk of nausea and vomiting. You may be prescribed medicine to prevent nausea, vomiting, and diarrhea while taking Fedratinib.
If you miss a dose of Fedratinib, skip the dose. The next scheduled dose of Fedratinib should be taken the next day at the usual time. Do not take two doses of Fedratinib at the same time to make up for a missed dose. It is important to make sure that you are taking the correct amount of Fedratinib each time. Before each dose of Fedratinib, check that what you are taking matches what has been prescribed.
Fedratinib blood levels can be affected by certain foods and drugs, so they should be avoided, including: Grapefruit, grapefruit juice, verapamil, amiodarone, diltiazem, fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, rifampin, phenytoin, St. John's wort, carbamazepine, phenobarbital and modafanil. Be sure to tell your doctor about all medications and supplements you are taking.

Store Fedratinib in its original, labeled packaging at room temperature and in a dry place (unless otherwise directed by your doctor or pharmacist). Fedratinib should not be stored in the box. Keep Fedratinib out of reach of children and pets.
Ask your doctor where to return any unused medicine for disposal. Do not flush Fedratinib down the toilet or throw it in the trash.

The most common or important side effects of Fedratinib include:
Brain and nervous system problems: Serious neurological problems have happened with Fedratinib, including Wernicke's encephalopathy (a disorder). encephalopathy due to low thiamine or B1 levels). Your doctor will monitor several blood tests before, during, and after treatment, including thiamine levels. Tell your doctor if you have poor nutrition or sudden weight loss. Tell your doctor right away if you have changes in vision or balance, trouble walking, trouble thinking, or if you feel confused or very drowsy. Diarrhea: Your doctor may recommend medications to relieve diarrhea. Also, adjust your diet, avoiding raw fruits, vegetables, whole-grain breads, grains, and seeds. Fiber is soluble in some foods and absorbs fluids, which can help relieve diarrhea. Drink 8-10 glasses of non-alcoholic, caffeine-free water each day to prevent dehydration. Nausea or vomiting: Talk to your doctor so they can prescribe medication to help you control nausea and vomiting. In addition, dietary changes may be helpful. Avoid foods that are greasy, spicy or acidic (lemon, tomato, orange). Call your doctor if you feel light-headed or dizzy at any time. Kidney problems: Fedratinib can cause kidney problems, including increased creatinine. Your doctor can monitor using blood tests. Notify your doctor if you notice decreased urine output, blood in your urine, swollen ankles, or loss of appetite. Hepatotoxicity: Fedratinib can cause liver toxicity, which your doctor can monitor using liver function tests. Notify your doctor if you notice yellowing of your skin or eyes, dark or brown urine, or pain in your abdomen, as these could be signs of liver toxicity. Anemia: Red blood cells are responsible for carrying oxygen to the tissues in your body. When your red blood cell count is low, you may feel tired or weak. You should let your doctor know if you experience shortness of breath, shortness of breath, or chest pain. If your red blood cell count is too low, you may receive a blood transfusion. Thrombocytopenia: Platelets help with blood clotting, so when the number of these cells is low, you have a higher risk of bleeding. Tell your doctor if you have any excessive bruising or bleeding, including nosebleeds, bleeding gums, or blood in your urine or stools. If the platelet count becomes too low, you may be given a platelet transfusion. Leukopenia or neutropenia: White blood cells (WBCs) are important for fighting infections. While being treated with Fedratinib, your white blood cell count may drop, putting you at higher risk of infection. You should tell your doctor or nurse right away if you have a fever (temperature higher than 38°C), sore throat or cold, trouble breathing, cough, burning when urinating, or pain that doesn't heal.

Exposure of the fetus to the drug Fedratinib can cause birth defects, so it is not recommended to become pregnant or fathering while using this medicine.
Effective birth control is needed during treatment with Fedratinib. Even if your period has stopped or you believe you are not producing sperm, you may still be able to conceive. You should not breast-feed while taking Fedratinib and for at least 1 month after your last dose.
Above is all the information to note about the drug Fedratinib. Using the medicine according to the instructions will help bring better treatment results.