Uses of ixazomib

Ixazomib works by inhibiting the 20S proteasome enzyme, which is an enzyme responsible for breaking down proteins in all cells (including healthy or cancerous cells). By inhibiting the activity of the 20S proteasome enzyme, the protein accumulates in the cells and causes the cells to die, thereby preventing the growth of tumors.

The drug ixazomib is one of the important drugs used in the treatment of multiple myeloma that has been treated at least once before, given in combination with lenalidomide and dexamethasone.
In patients treated for multiple myeloma with repeated recurrence, the combination of ixazomib and lenalidomide demonstrated a superior cytotoxic synergistic effect on multiple myeloma cell lines.

Ixazomib is in the form of capsules, taken with water, do not crush, chew or open the capsule. Take the full dose at least 1 hour before meals or at least 2 hours after meals. Do not use ixazomib at the same time as dexamethasone. Patients can take dexamethasone with food.
You will be given a timetable to monitor the progress of this medication. If you miss a dose, take that dose only if your next dose is more than three days (72 hours) apart. Do not double the dose to make up for the missed dose. If you vomit right after taking the medicine, do not take the dose again, but take the next dose on time.
It is very important to use the correct dose each time, before taking, always double check that the dose you are taking matches the dose prescribed by your doctor. If you overdose, contact your doctor immediately or go to the nearest medical facility.
Drugs can cause recurrence of Herpes roster. Antiviral medications can be used to prevent this from happening, so tell your doctor if you have a history of herpes zoster.

Ixazomib should be stored in its original, labeled packaging and stored at room temperature, in a cool, dry place (unless otherwise directed by your doctor). Keep out of reach of children and pets, avoid storing in the family medicine cabinet because it can cause confusion when using.
If the caregiver is preparing the medication, wear gloves or pour the medication directly from the container into the lid, small cup or directly into your hand, avoiding touching the tablet. Always wash your hands before and after giving you the medication. Do not let pregnant or lactating women prepare the medicine.
Regarding disposing of unused ixazomib drugs, you should look for places to collect drugs, do not flush them down the toilet or throw them in the trash

Ixazomib is usually available in some specialty pharmacies. When you are prescribed a prescription, you will be assigned a network specialty pharmacy to deliver and deliver the medication directly to where you live.

Contact your doctor about some things you can do to manage the side effects of ixazomib .
Some common side effects such as:
Thrombocytopenia: Platelets play a role in the body's blood clotting process, when the platelet count is low, there is a higher risk of bleeding. Tell your doctor right away if you have symptoms such as bruising or bleeding including nosebleeds, bleeding gums, or blood in your urine or stools. If the platelet count is too low you may be prescribed a platelet transfusion
Some notes to limit bleeding:
Do not use razors (may use electric razors) Avoid sports or activities with high risk of injury or bleeding Do not use aspirin, non-steroidal anti-inflammatory drugs (NSAIDs) such as Motrin/Advil (ibuprofen), Aleve (naproxen), Celebrex (celecoxib),... as they are both may increase the risk of bleeding. You should consult your doctor before taking any of these or any other over-the-counter medications/supplements. Do not use dental floss or toothpicks, instead use a soft-bristled toothbrush Your platelet count will be monitored at least once a month during ixazomib use. Leukopenia or neutropenia
White blood cells (WBCs) are important in the process of reducing inflammation. During treatment with ixazomib your white blood cell count may drop, which increases your risk of infection.
Tell your doctor if you have symptoms such as fever (temperature above 38 degrees Celsius), sore throat or cold, shortness of breath, cough, burning when urinating or wounds that take a long time to heal.
Some ways to reduce the risk of infection:
Wash your hands well, both yourself and those you visit, this is the best way to prevent the spread of infection Avoid crowded places or people are sick (such as a cold, fever, cough, or people living with people who have these symptoms) When working or working, wear protective clothing, gloves and boots Do not contact or clean up waste of pets Always keep open wounds clean and ventilated Take daily baths and do not forget to take care of your teeth Do not cut your nails too deep, or make artificial nails Diarrhea
During the use of ixazomib medicine can Diarrhea occurs, notify your doctor for advice on some suggestions to minimize this condition. In addition, you can increase the use of low-fiber foods, bland foods such as white rice, boiled or grilled chicken. Avoid raw fruits and vegetables, wholegrain breads, grains and seeds. Soluble fiber found in some foods can reduce symptoms of diarrhea. Foods that contain soluble fiber ingredients include: apple sauce, ripe bananas, canned fruit, boiled potatoes, white rice, white flour products, oatmeal, ..
Drink 8-10 cups of alcohol-free, caffeine-free water a day to prevent dehydration.
Constipation
Some ways to prevent or relieve constipation include increasing fiber in your diet (fruits and vegetables), drinking 8-10 glasses of non-alcoholic water a day and staying active.
Using a stool softener once or twice a day also helps relieve constipation. If you do not have a bowel movement in 2-3 days, contact your doctor immediately for instructions on how to treat this symptom of constipation.
Nausea and vomiting
Always remember to notify your doctor if you have symptoms of nausea or vomiting for treatment instructions. Changing your diet can also help with this problem, avoiding foods that can make this symptom worse, such as foods that are greasy, fatty, spicy, or acidic, such as lemons and tomatoes. sour, orange. Salt water or ginger water can be used to relieve symptoms.
Peripheral neuropathy (Nightness or tingling in the hands and/or feet)
Peripheral neuropathy is a toxicity that affects the nerves. Causes numbness or tingling in the hands and feet, usually when wearing gloves or socks. This condition may be aggravated by increasing the dose of ixazomib .
For some people the symptoms will subside after stopping the drug, but in some people the condition will not go away completely. Tell your doctor if you experience numbness or tingling in your hands or feet, as they may need an adjustment in your dose of ixazomib.
Peripheral edema
Peripheral edema is swelling of the extremities due to fluid retention. May be swelling in places such as hands, arms, ankles, feet and legs.
Eye problems
While taking ixazomib, some patients developed symptoms such as blurred vision, dry eyes and conjunctivitis. If you have eye pain, redness or any change in vision, tell your doctor.
Some less common but important side effects include:
Rash: some patients may experience this, a rash, scaly skin or an itchy rash. To reduce symptoms, you can use alcohol-free moisturizers to apply, avoid moisturizers with perfume ingredients or scents because they can aggravate the signs of redness If there are signs on the skin. signs of dryness itchiness and cracking or bleeding always remember to keep it clean to avoid infection. Hepatotoxicity: ixazomib can cause liver toxicity, your doctor may direct you to perform liver function tests. If you develop symptoms such as jaundice, yellow eyes, or dark, brown urine, or pain in the abdomen, notify your doctor for immediate examination as these could be signs of liver toxicity. Effects on fertility
The use of ixazomib during pregnancy can lead to birth defects. Therefore, you should not become pregnant while your husband or wife is using ixazomib and for at least 90 days after treatment. Breast-feeding is not recommended while taking the drug and for 90 days after the last dose. Ixazomib is a prescription medication, so you should consult your doctor before using it. The information in the article hopes to give people a better overview of the effects as well as the side effects that using ixazomib may cause.
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Reference source: oncolink.org :