Uses of Loncastuximab tesirine-lpyl

Loncastuximab tesirine-lpyl is a monoclonal antibody conjugate drug used to treat large B-cell lymphoma. This is a drug-antibody conjugate (ADC), consisting of a humanized antibody that targets the CD19 protein.

Loncastuximab tesirine is sold under the brand name Zynlonta, which is an injection. This drug is indicated for the treatment of relapsed or refractory large B-cell lymphoma after at least 2 prior systemic therapies. The 2 therapies include nonspecific diffuse large B-cell lymphoma (DLBCL) and DLBCL arising from low-grade, high-grade B-cell lymphoma.

Loncastuximab tesirine-lpyl is given by injection/intravenous infusion. Dosage and schedule are determined by your treating physician. This medicine is taken with certain other medicines such as Dexamethasone by mouth or by intravenous infusion 2 times a day for 3 days, starting the day before you start Loncastuximab tesitine-lpyl.

When using Loncastuximab tesirine-lpyl, you may experience some of the following side effects:
Infection and low white blood cell count (leukopenia or neutropenia):
This medicine can cause life-threatening infections, with or without low white blood cell counts. White blood cells (WBCs) are important in fighting infections. While being treated, your white blood cell count may drop, putting you at higher risk of infection. You should tell your doctor or nurse immediately if you have a fever (temperature higher than 38°C), sore throat, cold, trouble breathing, cough or burning when urinating, pain that does not heal. Decreased Platelet Count:
Platelets help with blood clotting, so when the count is low, you have a higher risk of bleeding. Tell your doctor right away if you have any excessive bruising or bleeding. These include nosebleeds, bleeding gums, or blood in your urine and stools. In cases where the platelet count is too low, you may be prescribed a platelet transfusion. Anemia occurs:
Red blood cells are responsible for carrying oxygen to the tissues in your body. When your red blood cell count is low, you may feel tired or weak. You should let your doctor know if you feel short of breath or have chest pain. When the blood count is too low, you may be prescribed a blood transfusion. Hepatotoxicity:
This drug can cause liver toxicity, which your cancer care team can monitor using blood tests. Tell your doctor if you notice yellow skin or eyes, dark urine, pain in the abdomen. High blood sugar:
This medicine may increase blood sugar in patients with and without diabetes. Your doctor will monitor your blood sugar through laboratory tests. If you experience increased thirst, urination or hunger, blurred vision, headache, fruity breath, notify your treating doctor. Diabetics should closely monitor their blood sugar and report increases to their treating physician. Fatigue:
Fatigue is very common during cancer treatment and is a feeling of exhaustion that often does not subside with rest. During cancer treatment and for some time afterward, you may need to adjust your schedule to manage fatigue. Plan time to rest during the day and save energy for more important activities. Exercise can help fight fatigue. Rash:
Some patients may develop a rash, scaly skin, or itchy red bumps. Your skin can also be very sensitive to the sun. Avoid sun exposure, wear protective clothing and use sunscreen. Use an alcohol-free moisturizer on your skin and lips. Avoid moisturizers with perfumes or scents. Your doctor may prescribe a topical medication if itching is bothersome. Peripheral edema:
Peripheral edema is swelling of the extremities due to fluid retention. It can cause swelling of the hands, arms, legs, ankles, and feet. The swelling may become uncomfortable. Notify your doctor if you are experiencing any new or worsening swelling. Nausea or vomiting:
Notify your doctor for a prescription to help you control nausea and vomiting. In addition, dietary changes may be helpful. Avoid things that can worsen symptoms, such as heavy or greasy/fatty foods, spices, acidic foods (lemons, tomatoes, oranges). Try salt water or ginger ale to ease symptoms. Muscle or Joint Pain / Headaches and Headaches:
Symptoms of headache, muscle pain, and joint pain may occur while using this medicine. Notify your treating physician for a prescription for pain medication. Reproductive implications:
Exposure to this medicine can cause birth defects in an unborn baby, so you should not become pregnant or father a child while taking this medicine. Effective birth control is needed during treatment and for at least 9 months for women and 6 months after treatment for men, even if your periods have stopped or you believe I do not produce sperm. You should not breast-feed while you are taking this medicine and for 3 months afterwards. Above are the uses, doses and precautions when using Loncastuximab tesirine-lpyl. To ensure the safety of your health and maximize the effectiveness of treatment, you need to take the medicine exactly as directed by your doctor.

Reference source: oncolink.org