The effect of the drug Azifonten

What is Azifonten? Azifonten is a drug commonly used for infections caused by susceptible strains of bacteria. To better understand the effects of Azifonten as well as how to use it effectively, please read the following article.

Azithromycin has the ability to act through binding to the 50S ribosomal subunit, thereby inhibiting bacterial protein synthesis. Besides, it also has a broad antibacterial spectrum, after being tolerated in the body, peak plasma concentrations are reached after 2-3 hours.
Pharmacokinetic studies show that the concentration of Azithromycin in tissues is higher than in plasma (up to 50-fold). Drug concentrations in tissues such as prostate, lung or tonsils exceed MIC90 values ​​for various bacteria following a single 500 mg dose.
Based on the mechanism of action and effects of Azithromycin, the drug is indicated for use in cases of infections caused by susceptible bacteria such as:
Upper respiratory tract infections. Lower respiratory tract infections. Skin and soft tissue infections. Cases of non-gonococcal sexually transmitted infections. Chlamydia trachomatis infections do not cause complications in the genital tract.

2.1. Dosage It is recommended that the total daily dose be used in a single time a day.
For adults: A single dose of 1g (equivalent to 2 tablets) of Azithromycin is effective in treating sexually transmitted infections with Chlamydia trachomatis. For infections caused by other sensitive bacteria: Use a dose of 500mg/day (equivalent to 1 tablet/day), orally once a day, continuously for 3 days with a total dose of 1, 5g (equivalent to 3 tablets).
In addition, the patient can also take the drug according to another regimen, which is a single dose of 500mg (equivalent to 1 tablet) on the first day, then a dose of 250mg (equivalent to 1⁄2 tablets) per day. times, used continuously for 4 days with a total dose of 5 days is 1.5g.
For young children: Azithromycin suspension should be used for children weighing less than 45kg (with a dose of 10mg/kg/day, continuously for 3 days). The dosage for children weighing more than 45 kg is the same as that for adults.
Specific dosage for young children weighing less than 45kg is as follows:
Weighing less than 15kg (from 6 months to 3 years old): Use a total daily dose of 10mg/kg, should be taken once a day, continuously in 3 days. Weight from 15-25kg (3-7 years old): Use a measuring spoon (included in the box) (5ml = 200mg), use 1 time per day continuously for 3 days. Weight from 36 - 45kg (12 - 14 years old): Use 2 measuring spoons (10ml = 400mg). Use once a day for 3 consecutive days. There is still no information on the effectiveness and safety of Azithromycin for children under 6 months of age, so it should not be used in children in this age group.
2.2. How to use Because food can reduce the absorption of the drug, so Azithromycin should not be taken with food.
How to mix suspension:
Shake well the bottle of powder used to make Azithromycin suspension. Gently twist to open the cap of the plastic tube included in the box. Add the distilled water in the tube to the bottle and shake well. The reconstituted suspension is stable for up to 5 days if stored at room temperature.
2.3. Treatment of Overdosage There are currently no accurate data on Azithromycin overdose. Typical symptoms that patients may experience when taking an overdose of Macrolide antibiotics include: Nausea, vomiting, accompanied by severe diarrhea. In case of need or emergency, the patient should be assigned gastric lavage and general support.

3.1. Contraindications Azithromycin is contraindicated in cases of known allergy or hypersensitivity to the components of the drug or to antibiotics of the macrolide group. Normally, if the patient is sensitive or allergic to any active ingredients or excipients in the composition of the drug, the drug should not be used. Other exceptions are specified in the medication leaflet or your doctor's prescription. Contraindications of Azithromycin are understood as absolute contraindications, ie not for any reason that the patient can flexibly use the drug.
3.2. Side effects Azithromycin is known to be a well-tolerated drug, with the majority of adverse reactions occurring in the gastrointestinal tract such as: Abdominal pain, nausea, vomiting, abdominal distention and diarrhea. As with other macrolides and penicillins, a reversible increase in hepatic transaminases has occasionally been observed.
Occasionally, patients may experience transient neutropenia in clinical trials, although a causal relationship with Azithromycin use has not been established.
In the process of using the drug, if you encounter unexpected side effects, the patient should consult a doctor.
3.3. Precautions for use Because of the potential risk of superinfection with non-susceptible bacteria as well as pseudomembranous colitis when used with broad-spectrum antibiotics, patients should be careful when taking Azithromycin. Because of the theoretical potential for ergot toxicity, the concomitant use of Azithromycin and ergot derivatives is not recommended. Dosage adjustment in patients with mild renal impairment (creatinine clearance > 40 ml/min) is not necessary. However, because there are no accurate data on the use of Azithromycin in patients with more severe renal impairment, special care should be taken when administering the drug to this population. Because the drug is eliminated mainly through the hepatobiliary system, it should not be used in patients with liver failure. Animal studies have shown that Azithromycin crosses the placenta, but have shown no evidence of harm to the fetus. The effectiveness and safety of the drug has not been proven in pregnant women, so it should not be used during pregnancy, unless absolutely necessary. It has not been reported whether Azithromycin is excreted in human milk. Therefore, the drug should not be used by women who are breastfeeding, unless absolutely necessary. 3.4. Drug Interactions Antacids can reduce the absorption of Azithromycin, so when both drugs are needed, Azithromycin should be taken 1 hour before or 2 hours after taking the antacid. Because Azithromycin and cyclosporin can interact if used in combination, cyclosporin concentrations should be checked, and dosage adjusted if co-administration is necessary. Some macrolide antibiotics have the ability to reduce the biotransformation of digoxin, although this effect has not been reported with the use of Azithromycin, but it is still important to be aware of the possibility of an interaction, and should be taken into account. Check digoxin levels. Similar to other macrolide antibiotics, patients should not combine Azithromycin with ergot derivatives. Thus, the article has helped us understand the effects of Azifonten and important information when using the drug. However, the above content is for reference only, patients should only use the drug when prescribed and guided by a doctor to ensure its effectiveness and safety.