Uses of Alenbone

Alenbone medicine contains the active ingredient Alendronic acid 70mg in the form of Alendronate Na. As for Alenbone plus, in addition to the main ingredient similar to Alenbone's, it is supplemented with Cholecalciferol with a content of 2800 IU. Both drugs are available in the form of tablets.

2.1.Indications Alenbone is indicated for use in the following cases:
Treatment of osteoporosis in postmenopausal women with osteoporosis to prevent fractures, including hip, spine and human fractures. diseases with a high risk of vitamin D deficiency. Prevention of fractures in men due to osteoporosis and cases of patients at high risk of vitamin D deficiency. Do not use Alenbone alone to treat vitamin D deficiency. 2.2.Contraindications If no indications are available. In particular, the drug should not be used in the following cases:
Abnormalities such as narrowing or loss of elasticity of the esophagus leading to delayed esophageal emptying. Inability to stand or sit for at least 30 minutes. Patients with hypersensitivity to the ingredients in the drug. The patient has hypocalcemia.

3.1. Dosage The recommended dosage is: 1 tablet of 10mg per day or a single tablet of 70mg Alendronat/2800 UI vitamin D3 per week. Elderly, liver failure or patients with mild to moderate renal impairment (creatinine clearance between 35 and 60ml/min) do not need to adjust the daily dose for these subjects. 3.2. How to use Patients must take Alenbone plus tablets whole with water (about 180-240ml) usually at least 30 minutes before eating, drinking or taking other drugs during the day. Do not take Alenbone before going to bed or lying in bed when you first wake up during the day. If instructions for dosing are not followed, the patient's risk and adverse effects may be increased. The patient should not take 2 tablets in the same day but return to take 1 tablet a week (70mg content) only on the right day of the week as originally selected.

Overdose: No specific information is available on the treatment of Alenbone overdose. Common symptoms include hypophosphataemia, hypocalcaemia, hypophosphataemia, and upper gastrointestinal adverse reactions such as heartburn, esophagitis, inflammation or gastric ulcer. Patients should use milk and antacids to bind Alendronate. Because of the risk of esophageal irritation, vomiting should not be caused and the patient should remain upright after taking an overdose. Missed dose: If you forget to take Alenbone as directed by your doctor, you can take one pill in the morning after discovering that you have missed a dose.

Possible side effects from taking Alenbone include:
Systemic: Common hypersensitivity reactions such as urticaria, rarely angioedema. Transient symptoms such as myalgia, malaise, weakness, and fever. The most rare are signs of hypocalcemia and peripheral edema. Gastrointestinal: Esophageal ulcers, esophageal scratches, nausea, vomiting are most common. Rarely are esophageal stricture or perforation, oropharyngeal ulceration, gastric or duodenal ulcer. Mandibular necrosis due to tooth extraction and/or local infection for a long time. Musculoskeletal: Joint swelling, pain in bones, joints and/or muscles, rarely severe and/or disabling. Nervous system: dizziness, dizziness. Skin: Rash, itching common. Stevens Johnson syndrome and toxic epidermal necrolysis are less common. Special Senses: Rarely with keratitis, scleritis, or inflammation of the sclera.

Interactions with ingredients in the drug that can affect the effectiveness of the drug as well as cause adverse reactions for users of the drug, including:
Interactions with the ingredient Alendronate Sodium:
Estrogen : Levels Safety and efficacy of concomitant use of hormone replacement therapy and Alenbone in postmenopausal women have not been established. Calcium supplements and antacids: may reduce the absorption of active ingredient alendronate. Therefore, patients should wait at least half an hour after taking Alenbone before taking other medicines. When this drug is used in doses greater than 10 mg/day concurrently with aspirin-containing compounds, there is an increased incidence of upper gastrointestinal adverse reactions. Non-steroidal anti-inflammatory drugs (NSAIDs): Can be used in combination with Alendronate. However, it can also cause gastrointestinal irritation, so it should be used with caution. Other drinks (including mineral water), food, and some medications can decrease the absorption of Alenbone. Interaction with ingredients Cholecalciferol (Vitamin D3)
Interferes with the absorption of vitamin D3 when taken with Olestra, mineral oils, orlistat, bile acid recoverers. Anticonvulsants and thiazide diuretics may increase vitamin D catabolism.

Caution when using Alenbone in the following cases:
Caution in patients with diseases of the upper gastrointestinal tract (dysphagia, esophageal disease, gastritis, duodenitis) or ulcer) due to the potential for irritation of the gastrointestinal mucosa and the risk of exacerbation of the disease. Causes of osteoporosis other than estrogen deficiency, advanced age, and glucocorticoid use should be considered. Patients with hypocalcemia must be treated before starting treatment with Alenbone. As well as cases of vitamin D deficiency must be treated effectively. Patients need supplemental calcium and/or vitamin D if its content in the diet is not enough. Alenbone is not recommended for people with severe renal impairment (creatinine clearance <35ml/min). Vitamin D3 may increase serum calcium levels and/or hypercalciuria when administered to patients with conditions associated with unregulated excess of calcitriol (leukemia, lymphoma, sarcoidosis). Serum and urine calcium levels should be monitored in patients. The use of Alenbone in pregnant and lactating women is not recommended because there are no clinical studies to determine safety in this population. Alenbone is indicated for the treatment of osteoporosis in patients. To ensure the effectiveness of treatment and avoid side effects, patients need to strictly follow the instructions of the doctor or pharmacist.
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