Uses of Daxame

Daxame is a medicine used in the treatment of infections caused by susceptible strains of bacteria such as sinusitis, pharyngitis, pneumonia, bronchitis and many other conditions. To learn the basic information about the drug, please refer to the information in the article below.

Daxame medicine contains the main ingredient is Cefixim (as Cefixime trihydrate) 200mg. This is a 3rd generation cephalosporin semisynthetic antibiotic for oral administration. The mechanism of action of Cefixim is to bind to target proteins (penicillin-binding proteins) that inhibit the synthesis of mucopeptides in the bacterial cell wall.
Cefixime has a broad antibacterial spectrum, is active mostly against gram-positive bacteria such as streptococcus pneumonia, Streptococcus pyogenes. In addition, some gram-negative bacteria are also affected by the drug, including: Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae.
According to published research documents, Daxame drug is slowly absorbed orally, requiring about 2 to 6 hours after use. The half-life of the active substance Cefixime in the drug is from 3 to 4 hours but can also be increased 2 to 4 times in patients with renal failure because the drug is eliminated mainly by the kidneys.

2.1. Indications With the above effect, Daxame drug is indicated for use in the following cases:
Patients with uncomplicated urinary tract infections caused by susceptible strains of E. coli or Proteus mirabilis and some cases suffering from uncomplicated infections caused by other typical gram-negative bacilli such as citrobacter spp, Enterobacter - spp, Klebsiella spp, Proteus spp... Patients with pyelonephritis and urinary tract infections with etiological complications caused by susceptible Enterobacteriaceae bacteria. Middle ear infections caused by bacteria Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes. Pharyngitis and tonsillitis are mainly caused by Streptococcus pyogenes bacteria. Acute and chronic bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae or Moraxella catarrhalis. Patients with mild and moderate community-acquired pneumonia. Use of Daxame in the treatment of uncomplicated gonorrhea caused by Neisseria gonorrhoeae, typhoid caused by Salmonella typhi and dysentery caused by susceptible Shigella bacteria. 2.2. Contraindications Daxame should not be used in patients with a history of hypersensitivity to cefixime or to other cephalosporin antibiotics, who have a history of penicillin-induced anaphylaxis.

Patients can use Daxame drug with reference dosage as follows:
Daxame dosage for adults
Common infectious diseases: Use with a dose of 400mg/day, can be used once or divided into 2 times 12 hours apart. Use in the treatment of uncomplicated gonorrhea caused by Neisseria gonorrhoeae: Use the drug with a single dose of 400mg. Used in the treatment of disseminated gonorrhea, which has been started with injections of ceftriaxone, cefotaxime, ceftizoxime or spectinomycin: 400mg orally twice a day for 7 days. Daxame dosage for children
For children over 12 years old or weighing > 50kg: The dose can be used as in adults. For children over 6 months to 12 years old: Use the drug at a dose of 8mg/kg/day, can be used once a day or divided into 2 times, paying attention to each time 12 hours apart. The duration of treatment with Daxame depends on the type of infection, but most should be extended for 48-72 hours after the symptoms of infection have resolved. In the case of patients with uncomplicated urinary tract infections and upper respiratory tract infections, the appropriate duration of treatment should be 5-10 days. In case of lower respiratory tract infections and otitis media, the treatment time may be longer from 10-14 days.
Daxame dose for patients with renal failure
Patients with creatinine clearance > 60ml/min do not need to adjust the dose. In patients with creatinine clearance <60ml/min, the dose and frequency of use of Daxame must be changed depending on the degree of renal impairment. Specifically, the creatinine clearance is 21-60ml/min at the dose of 300mg/day, the creatinine clearance is <20ml/min at the dose of 200mg/day.

Daxame has the risk of causing some side effects such as:
Digestive disorders: Accompanied by common signs such as diarrhea, abdominal pain, nausea, vomiting, flatulence, decreased appetite when eating, pseudomembranous colitis, ... Affects the nervous system: Causes patients to feel headache, dizziness, restlessness, insomnia, fatigue. Hypersensitivity: Daxame drug causes erythema, urticaria, fever due to the drug. Patients need to inform the doctor about the side effects when they appear for timely support.

Daxame may interact with some of the following drugs:
Concomitant use with Probenecid has the risk of increasing the peak concentration and AUC of Cefixime, reducing renal clearance as well as affecting the volume of distribution of cefixime. medicine. Concomitant use with anticoagulants increases prothrombin time, with or without bleeding. Concomitant use of carbamazepine often increases plasma concentrations of carbamazepine. Concomitant use with Nifedipine increases the bioavailability of Daxame.

Before starting treatment with Daxame, the patient should inform the doctor about the history of allergy to penicillins and other cephalosporins. Daxame should be used with caution in patients with a history of gastrointestinal disease and colitis, especially with prolonged use because of the risk of overgrowth of resistant bacteria. Pregnant women only use Daxame when clearly needed. If the drug is used during breast-feeding, breast-feeding should be discontinued. Above is some basic information to help you know what Daxame drug effectively treats. The use of drugs should strictly follow the doctor's instructions on dosage, how to use to avoid causing drug resistance, to help the drug promote its effectiveness in the treatment of the disease.