Uses of Divascol

What is Divascol? Divascol is a drug prepared in the form of a solution for intravenous infusion, packaged in a box of 10 ampoules of 1ml each. In 1ml of solution contains active ingredient Tolazolin hydrochloride 10mg. The active ingredient Tolazolin has a vasodilator effect due to a direct effect on peripheral vascular smooth muscle and an indirect effect produced, partly due to the release of endogenous histamine. In addition, Tolazoline has moderate alpha-adrenergic blocking activity and histamine agonist activity. Tolazoline generally reduces pulmonary artery pressure and vascular resistance.
Divascol is specified in what cases? Divascol is used to reduce pulmonary vascular resistance (known as Pulmonary vascular resistance (PVR)) in persistent pulmonary hypertension in neonates (known as Persistent Pulmonary Hypertension of the Newborn (PPHN).
In addition, Divascol is indicated for patients with peripheral spasmodic disorders, such as acrocyanosis, paresthesia of the extremities, scleroderma, occlusive arteriosclerosis, and diabetic vascular sclerosis. , thrombophlebitis (Buerger's disease), endarteritis, thrombophlebitis, Raynaud's disease.

2.1. How to use Divascol medicine is prepared as an intravenous infusion, should be done under the supervision of a medical professional.
Advice: Patients should take the maintenance dose at a lower level than the standard dose for patients who urinate in small amounts, to avoid excessive drug accumulation in the body. A response must be evident for up to half an hour after the first dose of therapy. The initial dose is a low dose, then gradually increased to an effective therapeutic dose.
Can increase the effectiveness of treatment by keeping the patient warm.
2.2. Dosage In the case of neonates: Initiate the therapeutic dose, inject slowly (within 10 minutes) a dose of 1 - 2 mg of Tolazolin hydrochloride per kg of body weight, into a vein in the scalp. Then, intravenous infusion at a dose of 1 - 2 mg Tolazolin hydrochloride per kg body weight over 1 hour. In case of patients being treated for peripheral vasospasm disorders: It can be administered subcutaneously or intramuscularly, intravenously with the usual dose in adults is 10 - 50 mg Tolazolin hydrochloride each time x 4 times/day. What to do in case of an overdose of Divascol?
Symptom: drop in blood pressure. Treatment: Keep the patient in the supine position, with the head low, and administer a suitable electrolyte solution to maintain the pulse. Use ephedrine to treat low blood pressure.

Divascol is contraindicated in the following cases:
Patients with hypersensitivity to Tolazolin hydrochloride or any of its ingredients. The following patient had a cerebrovascular accident. Patients with coronary artery disease or suspected. The patient has a history of severe hypotension, peptic ulcer.

Common, ADR > 1/100
Nervous system: headache, dizziness, chills, hair stand up, ant bites, chills, sweating, flushing. Digestive system: epigastric pain, nausea, diarrhea. Cardiovascular system: Hypotension or slight increase may occur. Uncommon, 1/1 000 < ADR < 1/100
At high doses, orthostatic hypotension occurs. Blood: Pancytopenia, agranulocytosis, thrombocytopenia. Metabolism: Hypochloremia, metabolic alkalosis. Rarely, ADR <1/1 000
Urinary system: Oliguria, hematuria. Nervous system: Confusion or hallucinations. Cardiovascular system: Hypertension, tachycardia, arrhythmia, myocardial infarction , angina pectoris. When very high doses of Divascol or intravenous administration are used, a decrease in blood pressure may occur.

Drugs that interact with Divascol may occur during use as follows:
Alcohol: when combined with Divascol, it will cause accumulation of acetaldehyde in the liver leading to liver toxicity and creating a feeling of fear of alcohol. Epinephrine, norepinephrine: when combined with Divascol leads to a severe paradoxical drop in blood pressure and especially when used in high doses causes a very strong rebound in blood pressure. Dopamine: When combined with Divascol, blood pressure drops dramatically. Ranitidine: When combined with Divascol, the effect of reducing pulmonary vascular resistance and general circulation is ineffective, leading to treatment failure. In summary, Divascol is a drug containing the active ingredient Tolazoline used to reduce pulmonary vascular resistance in persistent pulmonary hypertension in neonates and patients with peripheral vasospasm disorders.
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