Uses of Exad

Exad is a gastrointestinal drug whose main ingredient is Nizatidine. The drug is used to treat gastrointestinal diseases such as peptic ulcer or gastroesophageal reflux disease. To know more about Exad drug information, we read the article below.

The main ingredient Nizatidine in Exad is an H2-histamine antagonist diuretic. Nizatidine is rapidly and completely absorbed in the urine. Reaching high plasma concentrations after 1-2 hours, the oral absorption of nizatidine is about 75-100%.
Because Nizatidine has a formula similar to histamine, H2-histamine antagonists compete with histamine at the H2 receptor in gastric parietal cells, thereby preventing increased secretion of gastric juice. In addition, the drug reduces both the amount and concentration of HCl in the gastric juice. Furthermore, the drug has no effect on H1 receptors but only selectively on H2 receptors in the stomach and Nizatidine has no effect on cytochrome P450 in the liver.
Exad is indicated for the following cases:
Inflammatory disease of the stomach and duodenum is progressing. The patient has gastroesophageal reflux disease. On the other hand, this drug is contraindicated in patients with hypersensitivity or irritation to any component of Exad & other H2-receptor antagonists.

In case of advanced peptic ulcer: Take 300mg/day, take it in the evening or take 150mg/time x 2 times/day. Maintenance dose to prevent relapse: 150mg/time/day. Use for 8 weeks. In case of progressive benign gastric ulcer: Oral 300mg/time/day, orally in the evening or 150mg x 2 times/day. Use for 4-8 weeks. In case of gastroesophageal reflux: Take 150mg/time x 2 times/day, can be up to 300mg/time x 2 times/day. Use for 12 weeks. If the patient has renal impairment, the dose should be adjusted accordingly.

In the course of taking the drug may encounter the following side effects:
Anemia, itching, rash, urticaria. Hepatocellular damage: hepatitis and jaundice, cholestasis or hepatocellular injury with cholestasis with jaundice also recovered well after nizatidine was discontinued. Cardiovascular: Short episodes of asymptomatic ventricular tachycardia may occur. Transient psychosis (rare). Decreased libido Thrombocytopenia, thrombocytopenic purpura after taking nizatidine. Sweating and urticaria, erythema, and exfoliative dermatitis are common in nizatidine users.

Do not use the drug for people with malignant stomach disease. Use with caution in people with impaired liver and kidney function. Caution when using for pregnant women, lactating women, weigh the benefits and risks. Exad is a medicine used to treat peptic ulcer disease and gastroesophageal reflux disease. However, to ensure the safe use of the drug, the correct indication and the dose of Exad drug should be used according to the doctor's prescription. If you have any questions about the use of the drug or the side effects of the drug, please consult your doctor / pharmacist for advice.