Uses of Glosardis 40 and 80

Glosardis drug has the following strengths: Glosardis 40mg (including 40mg Telmisartan) and Glosardis 80mg (including 80mg Telmisartan). Telmisartan (a new antihypertensive agent) is a specific angiotensin II receptor antagonist. Angiotensin II is a potent vasoconstrictor that plays an important role in the pathophysiology of hypertension. In hypertensive patients, telmisartan is effective in reducing systolic and diastolic blood pressure without affecting heart rate.
Indications for the use of Glosardis:
Treatment of essential hypertension. Contraindications to the use of Glosardis:
Patients with hypersensitivity to Telmisartan or any other ingredient of the drug; Patients with biliary obstruction; Patients with severe liver failure; Pregnant and lactating women.

How to use: Patients need to take the drug orally. Patients can take Glosardis with or without food.
Dosage:
Adults: Use the recommended dose of 40mg/day. Some patients used a dose of 20mg/day to be effective. Alternatively, the dose may be increased to a maximum of 80 mg once daily to achieve target blood pressure. Telmisartan can be combined with a thiazide diuretic (hydrochlorothiazide). When an increase in dose is required, attention should be paid to the maximal hypotensive effect achieved after 4 to 8 weeks of treatment. For patients with severe hypertension, Telmisartan can be used at a dose of 160mg alone and in combination with hydrochlorothiazide 12.5-25mg/day; Patients with renal impairment: No dose adjustment is required, even for patients on hemodialysis because Telmisartan does not pass through the membrane when dialysis; Patients with hepatic impairment: Do not exceed 40mg/time/day in patients with mild and moderate hepatic impairment; Elderly: No need to change the dose. Overdose: There is limited information on overdosage with Telmisartan. Signs of telmisartan overdose may be hypotension and abnormally fast/slow heart rate. Management is to discontinue Telmisartan and monitor the patient closely. If an overdose occurs when taking Glosardis, the patient will be treated symptomatically and supportively. Hemodialysis cannot remove telmisartan from the circulation.

Some side effects patients may encounter when using Glosardis 40 and 80 include:
Infections and parasites: Upper respiratory tract infections, urinary tract infections; Psychiatric: Anxiety, restlessness; Eyes: Visual disturbances; Ear and ear labyrinth: Dizziness; Stomach - small intestine: Abdominal pain, dry mouth, flatulence, indigestion, diarrhea, digestive disorders; Skin and subcutaneous tissue: Increased sweating, eczema; Musculoskeletal system, connective tissue: Back pain, joint pain, leg pain, muscle pain, leg cramps, tendinitis-like symptoms; Systemic: Chest pain, flu-like symptoms, erythema, itchy skin, insomnia, syncope, low blood pressure, bradycardia, tachycardia, thrombocytopenia, basophils, dyspnoea, weakness, edema , poor performance,... Patients should stop taking Glosardis and consult a doctor if they have sore throat, fever, difficulty swallowing, shortness of breath, angioedema,...

Before and while taking Glosardis 40 and 80, patients should note:
Caution when using Glosardis in patients with liver failure, renal failure, renal artery stenosis; In patients with intravascular volume depletion (treatment with high-dose diuretics), a drop in blood pressure with Glosardis may occur. This patient should be corrected for this condition before taking Telmisartan or starting at a lower starting dose; Because hyperkalemia may occur with the use of Glosardis, serum potassium levels should be controlled, especially in patients with renal impairment and the elderly; avoid taking this medicine with potassium-sparing diuretics; There is no experience with the use of telmisartan in pregnant women, and animal studies have shown that this drug may cause harm and death in the fetus and neonate. Therefore, Telmisartan is contraindicated in pregnancy, patients should stop taking Glosardis if pregnancy is detected; It is not known if Telmisartan is excreted in human milk, so it is best not to use Glosardis in a nursing woman; The safety and effectiveness of Telmisartan in children have not been established, so it is best not to use this medicine in children without your doctor's approval; Drowsiness or dizziness is a possible symptom of Glosardis. Therefore, patients should be careful when driving or operating machinery if they are using this medicine.

Drug interactions can lead to an increase in some adverse side effects or affect the therapeutic effect of one/several drugs. Therefore, patients need to inform their doctor about the medicines they are taking and the medicines they plan to take to receive appropriate advice. In addition, patients should not arbitrarily use, stop, or change the dose of any medicine without the permission of the doctor.
Some drug interactions of Glosardis 40 and 80 include:
The antihypertensive effect of Telmisartan is enhanced when used concurrently with other antihypertensive drugs; Concomitant use of Telmisartan with drugs that increase blood potassium such as potassium supplements, potassium-sparing diuretics or potassium-containing salts may increase blood potassium; Co-administration of lithium with telmisartan may result in an increase in serum lithium concentrations, with reversible toxicity. Therefore, it is recommended to monitor the level of Lithium in the blood when using these two drugs together; Telmisartan is metabolised by the cytochrome P450 enzyme system, which may affect the metabolism of some drugs metabolized by this enzyme; There were no clinically significant interactions when telmisartan was used concomitantly with hydrochlorothiazide; The plasma digoxin trough concentration was increased by 20% when telmisartan and digoxin were co-administered. Glosardis 40 and 80 are effective in the treatment of essential hypertension. When using the drug, users need to strictly follow the instructions and instructions of the doctor to ensure the best therapeutic effect and limit possible side effects.
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