Uses of Uscadigesic

Uscadigesic 500 is indicated for use primarily for the relief of mild to moderate pain and fever. Before and during the use of Adigesic 500, patients should carefully read all instructions on the product label and strictly follow the doctor's recommendations.

Uscadigesic 500 belongs to the group of pain relievers, antipyretics, non-steroidal anti-inflammatory drugs, treatment of Gout and diseases of bones and joints.
Adigesic 500 is prepared in the form of effervescent tablets, packed in a box of 10 blisters x 4 tablets or a tube of 10 tablets. Each uscadigesic tablet contains the following active ingredients:
Main active ingredient: Paracetamol 500mg. Other excipients: Sodium bicarbonate, Anhydrous citric acid, Polyvinyl pyrrolidone (PVP) K30, Aspartame, Polyethylene glycol (PEG) 6000 and Sodium benzoate.

Adigesic 500 is indicated for the treatment of mild to moderate pain and fever, specifically:
Analgesic: For temporary relief of mild to moderate pain, including pain toothache, headache, menstrual pain,... Adigesic promotes the most effective low-intensity pain relief in cases where the pain is not of visceral origin. However, the component Paracetamol has no effect on the treatment of rheumatism. It is used as an alternative to salicylates in patients with intolerance to this substance to relieve mild pain or reduce fever. Antipyretic: Paracetamol is commonly used to help lower body temperature in patients with common fever, harmful fever, or general antipyretic that is nonspecific and does not affect the course of the underlying disease.

3.1 Dosage of Adigesic 500 Dosage of Adigesic will be determined based on certain patients, including:
Adult dose: Take 1 tablet / time, < 8 tablets per day and each dose 4-6 hours apart. Dose for children aged 7 - 12: Take 1 tablet / time, < 4 tablets per day and each dose is spaced 4-6 hours apart. Patients with renal impairment: The interval between doses is from 6 to 8 hours, determined specifically based on the assessment of the degree of renal impairment. For children with creatinine clearance less than 10mL/min, Adigesic may be given 8 hours apart. For adults with a creatinine clearance of 10-50mL/min, each dose should be given 6 hours apart, and if the creatinine clearance is less than 10mL/min, each dose may be given 8 hours apart. Absolutely do not use Adigesic 500 for self-treatment for pain relief for more than 10 days for adults or more than 5 days for children, unless there are exact instructions from a specialist.
3.2 Instructions for proper use of Adigesic 50 0 Adigesic is in the form of effervescent tablets, so it should be completely dissolved in water and administered immediately. In the case of using Adigesic to lower a child's fever with a fever above 38.5 degrees Celsius, you need to take some of the following steps to help increase the effectiveness of this medicine:
Give your child plenty of fluids to drink. Remove layers of clothing for the child. Avoid leaving children in very hot areas. Give the baby a bath with warm water at a temperature not lower than 2 degrees Celsius (if necessary).

During pain relief and fever reduction with Adigesic 500, patients may experience some of the following common to rare side effects:
Common side effects: Skin rash, nausea, vomiting, hematopoietic disorders (pancytopenia, neutropenia/leukopenia), anemia, nephrotoxicity or nephropathy with long-term abuse. Rare side effects: Hypersensitivity reactions, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis and Lyell's syndrome. When any of the symptoms mentioned above occurs, the patient should immediately notify the doctor to diagnose the specific cause and find the most appropriate remedy.

5.1 Contraindication to use Adigesic 500 for which case? Adigesic 500 should be avoided in the following cases when there is no indication:
People with a history of allergy or hypersensitivity to Paracetamol and other excipients in the drug. People who have suffered from anemia many times. People with a deficiency of Glucose-6-phosphate dehydrogenase in the body. People with advanced liver disease. Women in pregnancy / nursing mothers. 5.2 What precautions should be taken while taking Adigesic 500? Before and during the use of Adigesic, patients need to be careful about the following:
Active ingredient Paracetamol in the drug is almost non-toxic with therapeutic doses, in some cases may cause skin reactions, such as urticaria/pruritic papule rash. In addition, Paracetamol may also lead to other hypersensitivity reactions, such as angioedema, laryngeal edema or (rarely) anaphylactoid reactions. When taking Paracetamol can lead to purpura, thrombocytopenia or neutropenia. Rarely, the use of Adigesic causes agranulocytosis. Patients with pre-existing anemia should use caution when taking Adigesic 500, because the drug can cause cyanosis with less obvious symptoms even though the blood level of Methemoglobin is dangerously high. Taking Adigesic with alcohol can increase liver toxicity, so patients should minimize or avoid alcohol while using this medicine. People with symptoms of severe skin reactions, such as toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), Steven-Johnson syndrome (SJS), or Lyell's syndrome requires extreme caution when administering Adigesic 500. In patients with hepatic/renal impairment, the dose of Adigesic may be reduced according to disease progression. People with heart disease, edema should be careful when using Adigesic. Moreover, the drug contains a certain amount of Na (estimated equivalent to 725mg of table salt), which can make it difficult for people who are abstaining from salt. 5.3 What drugs interact with Adigesic 500? The drug Adigesic when combined with the following drugs may cause interactions, specifically:
Using high doses of Adigesic with Indandion and Coumarin derivatives may slightly increase the anticoagulant effect. Severe fever is possible when adigesic hypothermia is used concurrently with phenothiazines. Increased risk of hepatotoxicity with long-term use of Adigesic with large amounts of alcohol. The use of Adigesic with some anticonvulsants (Barbiturates, Phenytoin or Carbamazepine) can induce enzymes in the liver microsomes, leading to increased hepatotoxicity of Paracetamol, thereby increasing the metabolism of drugs into substances harmful to the liver. Increased hepatotoxicity when Adigesic is used concurrently with Isoniazid. In summary, Adigesic 500 is mainly used to relieve pain and reduce fever of mild to moderate severity. The use of the drug should be carried out according to the prescription of a professional doctor to ensure safety as well as limit unnecessary side effects.