Uses of Wontran

Wontran is indicated for use in the management of acute pain. The drug has two main ingredients: Acetaminophen and Tramadol. To ensure the effectiveness of using Wontran, patients need to carefully read the instructions and strictly follow the instructions of the doctor, professional pharmacist.

Wontran drug has 2 main ingredients: Acetaminophen and Tramadol. The drug is prepared in the form of film-coated tablets and packaged in boxes of 10 blisters x 10 tablets. The effects of Wontran drugs are:
Tramadol in Wontran is a synthetic substance belonging to the group of central opioid analgesics; Tramadol together with the active metabolite o-desmethyl tramadol (M1) binds to the tumor receptor of neurons, has the effect of reducing the reuptake of norepinephrine and serotonin, thus reducing pain sensation; Metabolite M1 is 6 times more analgesic than tramadol and has a 200-fold higher affinity for the receptor; The main ingredient Acetaminophen is Paracetamol which belongs to the group of antipyretic and analgesic drugs. The mechanism of this substance is to reduce pain perception in nerve endings, so it increases the pain threshold, effectively reducing peripheral pain. Indications for use of Wontran:
Wontran is indicated for short-term pain relief within 5 days in cases of acute pain.

2.1. Dosage Dosage of Wontran drug will be adjusted according to each patient's condition. Accordingly, patients need to use the drug according to the dose prescribed by the doctor or refer to the dosage below:
For adults and children older than 16 years: Take 2 tablets / time every 4-6 hours, but do not use more than 8 tablets/day; For patients with renal failure with creatinine clearance less than 30ml/min: The maximum dose that can be used is 2 tablets once every 12 hours. 2.2.How to use Wontran drug is taken into the body through oral route. Before using, users need to carefully read the instructions for use to use the drug most effectively.
Treatment of overdose: The manifestations of overdose with tramadol and acetaminophen or of both components are different. Patients should adhere to the prescribed dose. In case of overdose and abnormal symptoms appear, the patient should stop using and immediately notify the doctor for timely advice.

3.1.Contraindications Wontran is contraindicated in the following cases:
People with hypersensitivity to tramadol, acetaminophen, other opioids or any of its ingredients; People who are using or have recently stopped taking an MAO inhibitor within 15 days; Newly treated intoxication with alcohol, sleeping pills, central analgesics, opioids, psychiatric drugs; People with opioid addiction; People with severe respiratory failure, severe liver failure; People with uncontrolled epilepsy; Children under 16 years old; Women who are breastfeeding their babies. 3.2.Side effects of Wontran drug During the use of Wontran drug, patients may encounter the following side effects:
Digestive disorders: Nausea or vomiting, abdominal pain, flatulence, indigestion, mouth dryness, difficulty in defecation, diarrhea; Central Nervous System Effects: Dizziness, headache, drowsiness or insomnia, loss of appetite, feeling nervous, restless, anxious, emotional, hallucinating, euphoric, increased tone, tremor; In addition, other side effects have been recorded such as: Itching, rash, fatigue, weakness, increased sweating, red face, upper respiratory infection;
Side effects related to Tramadol: Anaphylaxis, toxic epidermal necrolysis, Steven Johnson syndrome, elevated liver enzymes, low blood pressure or standing, cardiovascular collapse;
Side effects related to Acetaminophen:
Appearance of skin erythema or urticaria that may be aggravated with fever and muscle damage, leukopenia, neutrophil, pancytopenia; Appears hypersensitivity reactions, anaphylaxis with symptoms such as swelling of the face, mouth, throat, respiratory failure, rash, rash, vomiting. Patients need to stop taking the drug if these symptoms appear and quickly contact a doctor or medical agency for early treatment. 3.3.Caution Using the drug with pregnant and breastfeeding women: Wontran drug can cross the placenta and long-term use of Tramadol can cause addiction and withdrawal syndrome in infants. Therefore, the benefits and risks of drug use should be carefully weighed during pregnancy, before labor, and during labor. For women who are breastfeeding, Tramadol has been found in breast milk, but there is no data to show that the drug has harmful effects on the nursing infant. Therefore, the drug should not be used for women who are breastfeeding; Side effects of Wontran drug are headache, dizziness, hallucinations, drowsiness, so the drug should not be used when driving or operating machinery; Warning about symptoms of Steven Johnson syndrome, toxic skin necrosis syndrome, Lyell's syndrome, acute generalized exanthematous pustulosis; During treatment should not drink alcohol, because it increases the risk of acute liver failure; Do not use the drug in patients with a history of anaphylaxis to codeine, other opioids; Do not use concurrently with other drugs with the same active ingredient acetaminophen and tramadol; Opioid addicts avoid long-term use, because of morphine's addictive potential; Use with caution in people at risk of respiratory failure, increased intracranial pressure, head trauma; Reduce the dose of drugs if you are taking CNS depressants such as alcohol, opioids, anesthetics, hypnotics, phenothiazines, sedatives. In summary, Wontran is indicated for use in the management of acute pain. The drug has two main ingredients: Acetaminophen and Tramadol. To ensure effective use, users need to strictly follow the instructions of the doctor, professional pharmacist.
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