What is Zexif 200 and how is it used?

Zexif 200 is commonly used in the treatment of certain bacterial infections in both adults and children. So what is Zexif 200 and how does it work?

The main ingredient of Zexif 200 is Cefpodoxime, an antibiotic belonging to the third generation Cephalosporin group, resistant to beta-lactamases, resistant to ester hydrolysis in the intestine. Cefpodoxime, after being absorbed into the body, will act on two enzymes, which are Transpeptidase and D-Alanyl Carboxypeptidase and inhibit these two enzymes, thereby preventing the binding of magnetic particles to synthesize peptidoglycan, thereby inhibits bacterial cell wall formation. Thus, Zexif 200 inhibits the synthesis of the bacterial cell wall through the mechanism of inhibiting the formation of peptidoglycan - an important component to make up the bacterial cell wall, making the bacteria no longer intact. intact and easily destroyed.
The spectrum of action of Zexif 200 is similar to that of the third generation Cephalosporin antibiotics, which are more extended against gram-negative bacteria than the second generation Cephalosporins.
Acts on some gram-positive bacteria such as: Pseudomonas aeruginosa, Staphylococcus saprophyticus, methicillin-resistant Staphylococcus aureus, group A, B, C streptococcus,... Effect on gram-negative bacteria such as: E. coli, Proteus mirabilis and Citrobacter, Klebsiella, Haemophilus and Neisseria produce betalactamases.

Zexif 200 is indicated for the treatment of the following bacterial infections:
Upper respiratory tract infections including tonsillitis, pharyngitis, sinusitis and otitis media. Community-acquired acute pneumonia. Uncomplicated acute gonococcal infection. Uncomplicated urinary tract infections. Skin and skin structure infections. Zexif 200 is contraindicated in patients with a history of sensitivity to cefpodoxime proxetil.

For adults:
Upper respiratory tract infections use 100mg every 12 hours for 10 days. Community-acquired acute pneumonia 200mg every 12 hours for 14 days. Uncomplicated acute gonococcal infection using a single dose of 200mg. Uncomplicated urinary tract infections 100mg every 12 hours for 7 days. Skin and skin structure infections 400mg every 12 hours for 7-14 days. For children:
Acute otitis media use dose 10 mg/kg/day (maximum 400 mg/day divided into 2 times) orally for 10 days. Pharyngitis and tonsillitis use 10 mg/kg/day (maximum 200mg/day divided into 2 times) orally for 10 days. Zexif 200 should be administered with food. In patients with renal impairment with creatinine clearance less than 30 ml/min, the dosing interval should be increased to 24 hours. No dose adjustment of Zexif 200 is required in patients with cirrhosis.

Zexif 200 side effects reported in clinical trials are usually mild and transient, including:
Diarrhea Nausea, vomiting Abdominal pain Colitis Headache. Rare side effects when using Zexif 200 are:
Hypersensitivity reactions Rash Itching Dizziness, Thrombocytopenia or thrombocytopenia Leukopenia or eosinophilia. Zexif 200 is commonly used in the treatment of certain bacterial infections in both adults and children. To ensure the effectiveness of treatment and avoid side effects, patients need to take medicine according to prescription or consult a doctor, pharmacist for advice.
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