Notes when using Haginat 250

Haginat 250mg has the active ingredient Cefuroxim Axetil, which is used in the treatment of upper and lower respiratory tract infections such as sinusitis, otitis media, tonsillitis, oral infections... Let's find out the uses and benefits Note when using Haginat 250mg through the article below.

1. Uses of Haginat 250

1.1. Indications to use Haginat 250 Not everyone clearly understands what Haginat 250 is and what disease it treats. Accordingly, Haginat 250 powder packets or film-coated tablets contain the active ingredient Cefuroxim axetil, equivalent to 250mg of cefuroxime. The drug belongs to the group of antibiotics, indicated for the treatment of infections caused by susceptible bacteria in the following cases:
Upper and lower respiratory tract infections including: Sinusitis, otitis media, tonsillitis, dental infections mouth, pneumonia , acute bronchitis and exacerbations of chronic bronchitis; Genitourinary infections including: urethritis, cystitis, nephritis, gonorrhea, pyelonephritis; Skin and soft tissue infections include: Impetigo, pustules, boils. 1.2. Pharmacodynamics The active ingredient in the drug Haginat 250 is Cefuroxim Axetil, a precursor of Cefuroxim - a 2nd generation Cephalosporin antibiotic. The drug acts through inhibition of bacterial cell membrane synthesis. The antibacterial spectrum of Cefuroxime is very effective and specific against many pathogens, including beta-lactamase-producing strains of gram-positive and negative bacteria. In particular, Cefuroxime is a stable antibiotic with many Beta-lactamase enzymes of Gram-negative bacteria.
Cefuroxime is resistant to anaerobic and aerobic cocci, including gram-negative enterococci, penicillinase-secreting Staphylococcus. The antibacterial activity of Cefuroxime is high, so the minimum inhibitory concentration (MIC) is low, especially against strains of Meningococcus, Gonococcus and Streptococcus bacteria (groups A, B, C and G). In the previous stage, the drug also had a low minimum inhibitory concentration against beta-lactamase-producing strains of Klebsiella spp, Moraxella catarrhalis, Gonococcus and Haemophilus influenzae. However, now that the rate of bacteria resistant to Cefuroxime has increased, the MIC of the drug for these bacteria strains has also changed. Accordingly, the positive strains of Bacteroides, Enterobacter and Proteus indol have reduced their sensitivity to Cefuroxime antibiotics.
Some strains of bacteria are not sensitive to the drug, including Clostridium difficile, Acinetobacter calcoaceticus, Campylobacter spp... The strains of Staphylococcus epidermidis, Methicillin-resistant Staphylococcus aureus are all resistant to Cefuroxime.

1.3. Pharmacodynamics After taking Haginat 250, the active ingredient Cefuroxim axetil will be rapidly absorbed and hydrolyzed in the intestinal mucosa to the active form Cefuroxime, distributed into the extracellular fluid.
The drug has high bioavailability, is well absorbed after oral administration and is widely distributed throughout the body, including in pleural fluid, bone, sputum, aqueous humor and synovial fluid, across the blood-brain barrier when the meninges are inflamed. The drug crosses the placenta and is excreted in breast milk. The drug is not metabolized, but excreted unchanged, about 50% of the drug is filtered by the glomerulus and 50% excreted by the renal tubules, a small amount of Cefuroxime is excreted in the bile. Cefuroxime has high concentrations in the urine.
2. Dosage of Haginat 250 2.1. Dosage and administration of the drug Haginat 250 is prepared in the form of powder packs or film-coated tablets, should be taken orally after meals. Note that the drug should be used according to the course of 5-10 days, usually 7 days.
The dose of the drug depends on the disease and the patient's physical condition. For adults, the usual dose is 250mg twice a day. In case the patient has serious infections such as pneumonia, bronchitis, etc., the dose is 500mg x 2 times/day. In case of uncomplicated gonorrhea, a single dose of 1g is used.
2.2. Overdose Treatment - Taking drugs in larger than recommended doses will not improve symptoms, on the contrary, they can cause poisoning or serious side effects. In case the patient overdoses with Cefuroxime axetil, they should be taken to the nearest medical facility for timely examination and treatment.
- In case of acute overdose: Patients may experience symptoms such as vomiting, nausea and diarrhea. However, the drug can also cause neuromuscular hyperexcitability, seizures, especially in people with renal failure;
- Treatment of overdose: Patients need respiratory protection, intravenous fluids and ventilation support. If the patient develops convulsions, the drug should be discontinued immediately, and anticonvulsant therapy used as directed by the doctor. Performing hemodialysis can help remove drugs from the blood, but much of the treatment is supportive or symptomatic.
- In case of forgetting a medicine, the patient should take it as soon as possible when remembering. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the time of your dose. Note that patients should not double the prescribed dose of Haginat 250 when they forget to take it.
3. Side effects of Haginat 250 Usually Haginat 250 can cause mild and transient unwanted effects (ADRs). Some side effects are as follows:
Common reactions: rash, diarrhea; Uncommon reactions: Candida infection, eosinophilia, neutropenia, leukopenia, positive Coombs test; Nausea and vomiting, pruritus, urticaria, increased serum creatinine; Rare reactions: Toxic epidermal necrolysis, hemolytic anemia, Stevens-Johnson syndrome, fever, pseudomembranous colitis, erythema multiforme, cholestatic jaundice, mild elevation of liver enzymes ALT, AST; Interstitial nephritis, nephrotoxicity with temporary elevation of blood urea, serum creatinine, headache, agitation, appearance of convulsions, arthralgia.

4. Note when taking Haginat 250 4.1. Contraindications and cautions - Contraindications: Haginat 250 is contraindicated for patients with hypersensitivity to Cephalosporin antibiotics.
- Caution: Care should be taken when using Haginat 250 for the following cases:
Patients who have ever had an allergic reaction to penicillins; Patients with severe diarrhea during or after taking antibiotics may have pseudomembranous colitis; Caution should be exercised in patients on concomitant therapy with potent diuretics, in patients with a history of colitis; Caution should be exercised in cases of inexperienced use of cefuroxime in infants under 3 months of age. 4.2. Effects of the drug on special subjects - Pregnant women: Haginat 250 crosses the placental barrier, so it should be used with caution in pregnant women. It is important to consult a treating physician prior to use to weigh the benefits and risks.
- Women who are breastfeeding: Haginat 250 is excreted in breast milk, so it should be used with caution in lactating women. It is important to consult a physician prior to use to weigh the benefits and risks.
- Driving and operating machines: The drug has little effect on the ability to drive and use machines.
5. Drug Interactions - Drug-Drug Interactions: Haginat 250 may interact with other drugs to change the ability to work or increase side effects. Therefore, the patient needs to write a list of drugs to take or inform the doctor about the drugs being used, do not arbitrarily take drugs, change the dosage without the consent of the doctor. Some interactions of Cefuroxim with other drugs are as follows:
Concurrent administration of Cefuroxime with H2-blockers or antacids increases gastric pH and reduces the bioavailability of Cefuroxime. Therefore, it is necessary to take Cefuroxime and the above drugs at least 2 hours apart; Concurrent use of Cefuroxime and Aminoglycosides, potent diuretics can lead to nephrotoxicity; Probenecid slows down renal elimination of the drug, increases plasma concentrations and prolongs its retention. - Interaction with food and alcohol: Consult your doctor before taking the drug with food or drinking alcohol while taking the drug.
In summary, Haginat 250 is indicated for the treatment of upper and lower respiratory tract infections. For effective and safe use, patients should consult their doctor or pharmacist before using.