Uses of Cammic 250mg

Cammic 250mg drug contains the main active ingredient is tranexamic acid, which is an anticoagulant. Cammic 250mg drug is prepared in the form of a solution for injection with the content of 250mg/5ml.
Tranexamic acid is a synthetic derivative of the amino acid lysine. Tranexamic acid inhibits the breakdown of fibrin in blood clots. The mechanism of action of tranexamic acid is to prevent the activation of plasminogen into plasmin, so plasmin is not produced and plasmin does not bind to fibrin, preventing the dissolution of the hemostatic plug. Tranexamic acid inhibits the natural breakdown of fibrin, stabilizing blood clots. Tranexamic acid for the treatment of fibrinolytic bleeding that can occur in clinical situations such as multiple trauma and intravascular coagulation.

2.1.Indications Cammic 250mg is indicated for the treatment and prevention of bleeding associated with excessive fibrinolysis: Local fibrinolysis: Short-term use for prevention and treatment in high-risk patients bleeding during and after prostatectomy, colectomy, bladder surgery, tooth extraction in patients with hemophilia. Oral bleeding in patients with congenital or acquired coagulopathy Prevention of gastrointestinal bleeding, bleeding after eye trauma, recurrent nosebleeds. Limit blood loss during surgery (especially in heart surgery, joint replacement, liver transplant). Primary menorrhagia. Hereditary angioedema. Bleeding from an overdose of thrombolytics. 2.2.Contraindications Cammic 250mg is contraindicated for use in the following cases:
Patients with allergy or hypersensitivity to tranexamic acid. There is a history of thromboembolic disease or the patient is at risk of thrombosis such as cerebrovascular accident, myocardial infarction. Cases of central nervous system surgery, central nervous system bleeding, subarachnoid bleeding, acquired color dyschromia-type visual disturbances (due to not being able to monitor the toxicity of tranexamic acid in patients) . Severe kidney failure.

Cammic 250mg is administered intravenously or by slow intravenous infusion.
Dosage of Cammic: 250 - 500mg / day, used 1-2 times / day. Dose 500 - 1000 mg/time IV or 500 - 2500mg/time IV as needed during and after surgery. Overdose of Cammic 250mg and treatment
There have been no reports of an overdose of tranexamic acid. Symptoms of an overdose of tranexamic acid may be: nausea, vomiting, orthostatic hypotension.
Management: there is no specific measure to treat an overdose of tranexamic acid. If tranexamic acid toxicity is caused by an overdose, vomiting and gastric lavage or activated charcoal may be used. Maintain fluid replenishment to promote renal drug excretion. Treatment mainly applies symptomatic treatment and supportive treatment.

Undesirable effects of Cammic 250mg/5ml are rare and mainly appear as nausea, diarrhea or abdominal pain. These side effects are common with high doses, relieved by reducing the dose of tranexamic acid.
Care should be taken to reduce the dose of tranexamic acid in patients with renal impairment to avoid drug accumulation and increase undesirable effects. Hypotension may occur, especially after rapid intravenous infusion.
Digestion: vomiting, nausea, diarrhea. Cardiovascular: hypotension, thromboembolism (pulmonary embolism, deep vein thrombosis in legs, retinal artery occlusion, mesenteric thrombosis, aorta, intracranial artery thrombosis). Central nervous system: headache, dizziness, ischemia, cerebral infarction (when used to treat subarachnoid hemorrhage). Hematology: coagulopathy, thrombocytopenia, abnormal bleeding time. Vision: decreased visual acuity, chromatic abnormalities, central venous retinopathy. Urology: acute cortical necrosis in a patient with hemophilia A. Skin: skin rash including drug-fixed rash and bullous rash.

Patients with renal impairment: Adjust dose of Cammic when used in patients due to the risk of accumulation of tranexamic acid. Administration of tranexamic acid may inhibit the resolution of extravascular clots. A blood clot in the kidney can lead to a blockage in the kidney. Use with caution in patients with symptoms of hematuria (avoid if there is a risk of ureteral obstruction). Use with caution in patients with cardiovascular disease, cerebrovascular disease, kidney disease, transurethral prostatectomy. Patients with a history of thrombosis should not receive tranexamic acid, unless treated concomitantly with anticoagulants. Disseminated intravascular coagulation bleeding should not be treated with the antifibrinolytic agent tranexamic acid, unless the disease is primarily due to a disorder of the fibrinolytic mechanism. Women with irregular periods, pregnant women need to be careful when using Cammic. Check liver function and vision regularly with long-term use. Concomitant use of coagulation agents or factor IX complexes is not recommended because of the increased risk of thrombosis. Administration of tranexamic acid after subarachnoid hemorrhage may increase the incidence of cerebral ischemia. Ability to drive and use machines: Cammic 250mg/5ml medicine can cause drowsiness, so be careful when driving and operating machinery. Pregnancy: Tranexamic acid can cross the placenta. Research data on the use of tranexamic acid in pregnant women is scarce. Therefore, Cammic 250mg/5ml should be used during pregnancy only when the potential benefit outweighs the potential risk. Lactation: Tranexamic acid is secreted into breast milk in concentrations approximately 1% of maternal blood. Caution should be taken when using Cammic 250mg/5ml for women who are breastfeeding.

Estrogen: Should not be used concurrently with Cammic, because it can cause more thrombosis. Caution should be taken when co-administering Cammic 250mg/5ml with other hemostatic agents. Cammic 250mg drug is an anticoagulant drug, prepared in the form of an injectable solution with the content of 250mg/5ml. Cammic 250mg is indicated for the treatment and prevention of bleeding associated with excessive fibrinolysis. Taking the drug exactly as directed by the doctor and medical staff will bring high efficiency and limit side effects.
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