Uses of Cibinqo

Cibinqo belongs to the group of immunosuppressive drugs commonly used in autoimmune diseases such as atopic dermatitis (eczema) that do not respond to conventional treatments. So what are the effects of Cibinqo and the unwanted effects that may appear when taking the drug?

Cibinqo's main ingredient is Abrocitinib - an autologous immunosuppressant, specifically an inhibitor of the Janus Kinase (JAK) enzyme. When a foreign allergen enters the body, it will bind to a receptor on the cell membrane, activating the intracellular information transmission pathway in three ways: via G protein, through ion channels or through binding with the enzyme tyrosine kinase. JAK is a tyrosine kinase that plays an important role in the intracellular transmission of cytokines. Therefore, inhibiting the JAK enzyme will suppress the immune mechanism, reducing the aggressive inflammatory reactions in atopic dermatitis. In atopic dermatitis, when the skin barrier is damaged, lipid levels on the skin decrease, endogenous protein-digesting enzyme (tyrosine kinase) increases, thereby causing cells to lose water, deform, dry skin, and flake off. , causing inflammatory reactions. Cibinqo inhibits the production of endogenous proteins that reduce inflammation in the skin.

Cibinqo is indicated in the following medical conditions
Moderate to severe atopic dermatitis (eczema) unresponsive to conventional treatments. Autoimmune diseases of other skin systems in the body as prescribed by a doctor.

Do not use Cibinqo in the following medical conditions.
Patients who are allergic to Abrocitinib or any other ingredient of the drug. The patient is suffering from severe infectious diseases, blood infections, systemic infections. Patients with reduced number of blood cell lines such as anemia, leukopenia, thrombocytopenia. Patients with impaired liver and kidney function should not take Cibinqo. Patients with HIV infection, Herpes zoster virus infection. Skin cancer or some other related cancer. Currently being treated for tuberculosis or a history of tuberculosis. Pregnant and lactating women are not contraindicated to use Cibinqo because of the risk of toxicity to the fetus and nursing infant. Note when using the drug Cibinqo
Cibinqo weakens the body's natural immune system, so when taking the drug, it may increase the risk of infectious diseases. Use caution when administering the drug to patients with hypercholesterolemia, diabetes, cardiovascular disease, history of viral hepatitis B, C. Monitor lung function in patients with a history of chronic obstructive pulmonary disease. (COPD) throughout the course of medication. Check blood counts before and during medication. If a decrease in blood cell lines is detected, the drug should be discontinued. During the period of taking Cibinqo do not inject live vaccines.

There are no specific studies on drug interactions with Cibinqo. However, before using in combination with any other drug, consult a specialist. Tobacco, alcohol, and fermented foods can alter the bioavailability of the drug. Therefore, it should not be used during treatment with Cibinqo.

How to use
Cibinqo is in the form of oral tablets. Do not crush, break or chew the tablet. Dosage
The usual dose is 1 tablet (100mg)/day. Dosage is for reference only. Depending on the individual patient, the doctor will prescribe a different dose.

Some unwanted effects may be encountered when using Cibinqo
Flu, headache, nausea, chills, fatigue. Herpes simplex virus infection relapsing, shingles. Increased serum creatinine phosphokinase levels. Infectious diseases caused by bacteria, viruses, fungi, parasites. Back pain, musculoskeletal pain. Sore throat. Hypertension . Allergic reactions, rash, redness, itching of the skin. Gastritis . Decreased blood cell lines, especially thrombocytopenia. Increased risk of skin cancer, lung cancer, lymphoma. Increased risk of cardiovascular diseases, blood clot formation in the blood vessels, stroke, myocardial infarction. In summary, Cibinqo is an immunosuppressive drug that must be prescribed by a specialist in the treatment of atopic dermatitis. The drug relieves uncomfortable skin symptoms for patients well, but also causes a series of serious side effects. Therefore, the drug should be used under the close supervision of medical personnel.

Reference source: www.vinmec.com.