Uses of Diafase

Diafase drug is indicated as monotherapy or in combination with other drugs in the treatment of type 2 diabetes,... Let's learn about the uses and notes when using Diafase through the article below.

Diafase drug containing the active ingredient Metformin is prepared in two main concentrations, Diafase 500 and Diafase 850.
Diafase is indicated in the following cases:
Non-insulin-dependent type 2 diabetes: Monotherapy when diet alone is not effective; Combined with other drug groups such as Sulfonylure when diet alone or when using Sulfonylure, Metformin alone is not effective.

Metformin is an active ingredient of the Biguanide group. Unlike sulfonylureas, metformin does not stimulate insulin release from pancreatic beta cells, and has no hypoglycemic effect in non-diabetic patients.
In patients with diabetes, Metformin is effective in reducing hyperglycemia but does not cause hypoglycemia (except in cases where the patient is fasting or used in combination with drugs with synergistic effects). Metformin's peripheral mechanism of action helps to increase glucose utilization in cells, improve insulin's ability to bind to receptors, inhibit glucose synthesis in the liver, and reduce glucose absorption in the intestine. In addition, Metformin also has a beneficial effect on lipoprotein metabolism (this metabolism is often disturbed in patients with non-insulin-dependent diabetes mellitus).
Metformin monotherapy has shown good efficacy in patients who are non- or partial responders to sulfonylureas.

Diafase is taken orally, the tablet should be taken with food. Note that the patient should swallow the tablet whole, do not chew or crush the tablet.
Some recommendations on dosage of Diafase are as follows:
Diafase 500 : The recommended starting dose is 1 tablet/time x 2 times/day, the maximum dose should not exceed 4 tablets/day; Diafase 850: The recommended starting dose is 1 tablet/time/day, the maximum dose should not exceed 3 tablets/day; Maintenance dose: 500mg/time or 850mg/time x 2-3 times/day. Patients should note that the dosages listed above are for reference only. Diafase belongs to the group of prescription drugs, so the specific dose is prescribed by the doctor based on the patient's condition.

Diafase medicine can cause some side effects as follows:
Common: Nausea, vomiting, anorexia, diarrhea, constipation, epigastric fullness, heartburn, urticaria, skin rash, photosensitivity light, reduce the concentration of Vitamin B12; Uncommon: Aplastic anemia, blood dysplasia, hemolytic anemia, thrombocytopenia, myelosuppression, agranulocytosis, lactic acidosis. Patients should notify their doctor if they experience any side effects during treatment with Diafase.

Contraindicated to use Diafase in the following cases:
Patients with acute catabolism, trauma, infection (in these cases, diabetes should be treated with insulin); Patients with impaired kidney function due to kidney disease, kidney dysfunction; People with conditions such as cardiovascular collapse, sepsis, acute myocardial infarction; Patients with hypersensitivity to Metformin or any component of Diafase; Patients with acute or chronic metabolic acidosis, with or without coma; People with severe cardiovascular disease, severe liver disease, respiratory disease with a risk of hypoxia; Patients with cardiovascular collapse, congestive heart failure, acute myocardial infarction; People with chronic hypoxic lung disease; Pregnant women; The patient is undernourished, alcoholic, gangrene.

Patients being treated with Metformin should be regularly monitored for laboratory tests, including blood glucose levels. In addition, patients should be informed about the risk of lactic acidosis and the conditions that predispose to it.
Patients need to be advised about an appropriate diet, because nutrition in treatment is extremely important in diabetes management. Metformin treatment should only be considered adjunctive and not a substitute for appropriate dietary therapy.
Metformin is excreted by the kidneys, so the risk of drug accumulation increases with the degree of renal impairment.
Diafase is not suitable for the treatment of diabetes in the elderly with impaired renal function, so the patient should have the serum creatinine level checked before starting treatment.
Patients need to stop treatment with Metformin 2-3 days before conducting X-rays using iodinated contrast and 2 days after the scan, start treatment with Metformin again after assessing kidney function for patients. normal results.
It has been reported that treatment with antidiabetic drugs is associated with an increased risk of cardiovascular death compared with conventional diet therapy or insulin therapy in combination with diet.
Concomitant administration of Metformin with drugs affecting renal function affects the distribution of Metformin.
Do not treat with Metformin in patients with liver failure, stop treatment with Metformin during surgery.
For pregnant women: Metformin is contraindicated in pregnant women.
For women who are breast-feeding: There are currently no studies to prove the safety, the amount of drug excreted in breast milk. Therefore, caution and consideration should be taken when treating with Diafase in this subject.

Interactions reduce the effect: Concomitant use of Diafase with the following drugs reduces the ability to control glucose: Corticosteroids, diuretics, Estrogen, thyroid preparations, oral contraceptives, Nicotinic acid, drugs sympathomimetic, isoniazid, calcium channel blocker.
Interactions enhancing effect: Furosemide increases the plasma concentration of Metformin without altering the renal clearance of Metformin.
Interactions to increase toxicity: Drugs excreted by the renal tubules such as Digoxin, Amilorid, Procainamide, Morphine, Quinine, Quinidin, Trimethoprim, Triamteren,... can competitively interact with Metformin in renal tubules. This increases the concentration and risk of toxicity of Metformin.
Drug interactions occur that increase the risk of having an effect and reduce the therapeutic effect of Diafase, so to ensure safety and effectiveness in treating patients, it is necessary to inform the doctor about drugs and foods. were using before taking Diafase.