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Sodium Valproate Aguettant is a drug used to treat absence seizures, convulsions in children, myoclonic epilepsy, generalized convulsive epilepsy, tonic-clonic seizures, and febrile convulsions. So how to use this medicine? Let's find out the necessary information about the drug Sodium Valproate Aguettant through the article below.
1. What is Sodium Valproate Aguettant?
Pharmaceutical name: Sodium Valproate Aguettant 400mg/4ml Class: Medicine Registration number: VN-11589-10 Manufacturer: Laboratoire AGUETTANT Registered enterprise: Vimedimex Binh Duong One Member Co., Ltd. Ingredients: Sodium drug Valproate Aguettant 400mg/4ml contains the main ingredient, Sodium Valproate, other active ingredients and excipients with just the right amount of medicine provided by the manufacturer. Dosage form: Tubes Packing: Box of 10 ampoules of 4ml Content: 400mg/4ml
2. Uses of Sodium Valproate Aguettant
Indications
Temporary treatment of epilepsy in adults and children, instead of oral form when temporarily unable to use oral for treatment.
Dosage – Administration
Method of administration:
In the case of a simple replacement (eg, in elective surgery): 4 to 6 hours after the last oral dose, administer sodium valproate intravenously in sodium solution for injection. chloride 0.9%
may be given as a continuous intravenous infusion over 24 hours or in 4 divided doses per day of 1 hour each, at the same dose as previously administered (average common dose is 20 to 30 mg). /kg/day).
In cases where it is necessary to rapidly achieve therapeutically effective plasma concentrations and maintain these concentrations thereafter: 15 mg/kg intravenous bolus should be given over 5 minutes before a continuous intravenous infusion at a rate of 1 mg/kg/h and titrated gradually to achieve a blood valproic acid concentration of approximately 75 mg/L. Then, adjust the infusion rate according to the evolution of the clinical condition.
Immediately after stopping the infusion, reinstate oral administration to ensure immediate replacement of the eliminated drug. The dose can be used as before or after the dose has been adjusted.
Dosage:
Girls / teenage girls / women of reproductive age / pregnant women
Sodium Valproate Aguettant Injection 400 mg/ml must be started and monitored by a person who has a menstrual period. experience in the treatment of epilepsy.
This drug should only be used when other treatments are ineffective or the patient cannot tolerate it. The benefit-risk balance of the drug should be carefully evaluated during each routine patient visit. Ideally, Sodium Valproate Aguettant Injection 400 mg/ml should be prescribed as monotherapy and at the lowest effective therapeutic dose. If possible, the extended-release formulation should be used to avoid high peak plasma concentrations. The daily dose should be divided into at least 2 single doses.
Children: The dose may be increased to 40 mg/kg/day but only in patients whose plasma valproic acid levels can be monitored. When using doses above 40mg/kg/day, hematological and clinical biochemical indices must be monitored.
Adults: maximum dose 2500mg/day.
Overdose, missed dose, emergency
Overdose:
In case of emergency or overdose with dangerous manifestations, call 911 Emergency Center or go to the nearest local Health Facility. Relatives need to provide the doctor with the prescription they are taking, the medicines they are taking, including prescription and non-prescription drugs.
Missed dose:
In case you miss a dose while taking the medicine, take it as soon as possible (usually it can be taken 1-2 hours before the time ordered by the doctor). However, if it is almost time for your next dose, skip the missed dose and take your next dose at the prescribed time. Be careful not to double the prescribed dose.
3. Notes when using Sodium Valproate Aguettant
Contraindications
History of hypersensitivity to sodium valproate, divalproate, valpromide or one of the ingredients. Acute hepatitis. Chronic hepatitis. Personal or family history of severe hepatitis, especially drug-related. Porphyria metabolism disorders. Combined with mefloquine, or with the herb St. John's Wort (see Interactions with other drugs and other forms of interaction). Valproate is contraindicated in patients with known mitochondrial disorders caused by mutations in the mitochondrial nuclear polymerase (POLG) gene, e.g. Alpers-Huttenlocher syndrome, and in children. under two years of age with a suspected POLG-related disorder Urea cycle disorder. Precautions, warnings and precautions
Note before taking Sodium Valproate Aguettant 400mg/4ml
Use the drug according to the doctor's prescription. Do not use this medicine if you are allergic to any of its ingredients or have been warned by your doctor or pharmacist. Use with caution in children, pregnant or lactating women or operating machinery.
Precautions for taking Sodium Valproate Aguettant 400mg/4ml during pregnancy fetus,...) to any stage of pregnancy, especially the first trimester. Therefore, it is best not to use the drug for pregnant women. In the case of mandatory use, it is necessary to consult carefully with your doctor, pharmacist before making a decision.
Notes on using the drug Sodium Valproate Aguettant 400mg/4ml during lactation It is best not to or limit the use of the drug during breast-feeding. Many drugs have not yet fully determined the effects of the drug during this period, so mothers need to carefully read the instructions for use and consult with doctors and pharmacists before deciding to use the drug.
4. Drug interactions
When using two or more drugs at the same time, drug interactions often occur, leading to antagonism or synergism.
Drug interactions Sodium Valproate Aguettant 400mg/4ml with other drugs
What drugs can interact with Sodium Valproate Aguettant 400mg/4ml? For professionals or those with specialized knowledge. Do not arbitrarily research and apply without professional knowledge
Drug interactions Sodium Valproate Aguettant 400mg/4ml with food and drinks
When using drugs with foods or alcohol, beer, tobacco .. Because such foods and beverages contain other active ingredients, they may have an antagonism or synergistic effect with the drug. Read carefully the instructions for use of the drug or consult your doctor, pharmacist about taking Sodium Valproate Aguettant 400mg/4ml with food, alcohol and tobacco.
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