What is Loxoprofen?

Loxoprofen 60mg medicine has the main ingredient of Loxoprofen sodium 60mg compound along with other excipients. The drug is indicated for use in cases such as pain relief, anti-inflammatory treatment with symptoms of chronic rheumatoid arthritis, osteoarthritis, arthritis around the shoulder... In addition, the drug is also used to relieve mild to moderate pain or relieve muscle pain, neuralgia...

What is Loxoprofen 60mg? The drug contains the compound Loxoprofen sodium hydrate which has strong analgesic, anti-inflammatory and antipyretic properties. However, the special ability of the drug Loxoprofen 60mg is still a strong analgesic effect. This mechanism may be explained by the inhibition of prostaglandin synthesis constituting the action of loxoprofen. The site of action of the drug is the oxidizing ring. Loxoprofen for oral administration, loxoprofen sodium hydrate compounds are slowly absorbed into the gastrointestinal tract as unchanged compound with mild gastric irritation. Then, the drug Loxoprofen will be rapidly converted biologically to convert to a trans OH isomer that is active in synergism with SRS, along with inhibiting the biosynthesis of prostaglandins to form prostaglandins. pharmacological effects of the drug.
After the drug Loxoprofen is taken into the body, it will be quickly absorbed from the gastrointestinal tract in unchanged form and cause little irritation to the gastric mucosa. Accordingly, the drug is rapidly converted to an active metabolite OH derivative. Loxoprofen plasma concentrations peak at unchanged drug and metabolites after 30 minutes and 50 minutes, respectively. The half-life of the drug can be as long as 1.25 hours.
The activity of the drug Loxoprofen with plasma protein binding to the Loxoprofen component is about 97% and the trans OH derivative is about 92.8%. The AUC of Loxoprofen compound reached the average value of 6.7 ± 0.26 mg.h/mL and the trans OH compound was 2.02 ± 0.05 mg.h/mL.
Loxoprofen compounds are also rapidly eliminated in the urine with about 50% of the dose being eliminated in about 8 hours. The elimination dose is in the form of loxoprofen conjugated with glucuronate and the trans OH form.

What is Loxoprofen? Loxoprofen is a group of non-steroidal anti-inflammatory drugs (NSAIDS) belonging to the ETC group of over-the-counter drugs. Loxoprofen is indicated for use in the following cases:
Loxoprofen is used to relieve pain and anti-inflammatory of the symptoms of chronic rheumatoid arthritis, osteoarthritis, back pain, arthritis around the joints. shoulder, hand - shoulder - neck syndrome. Loxoprofen is used in activities to help relieve mild to moderate pain, and to help fight inflammation after surgery, trauma, and tooth extraction. Used to relieve muscle pain, neuralgia, migraine, headache, toothache or menstrual pain. Loxoprofen is used to reduce fever and inflammation caused by acute upper respiratory tract infections with or without bronchitis. However, Loxoprofen is contraindicated for use in some cases:
Patients with hypersensitivity to Loxoprofen or to the components of the drug People with a history of hypersensitivity reactions such as asthma, rhinitis, Angioedema, urticaria when using aspirin or other non-steroidal anti-inflammatory drugs should not use Loxoprofen Patients who are in the advanced stage of peptic ulcers People with severe heart failure, have disorders Severe hematological or hepatic, renal, pregnant women and lactating women should not use Loxoprofen.

Loxoprofen is available in tablet form and is taken orally. Patients can take the drug during or after meals. For adults, the usual recommended dose for each use is usually 60mg corresponding to 1 Loxoprofen tablet. Patients should use it three times a day. If the person is sick or is in an acute case, a single dose of 60mg-120mg can be used. However, the dose of the drug can be adjusted depending on the age and symptoms of the disease, but the patient should not exceed the dose of 180mg/day.
The above drug dosage is for reference only. Therefore, if you use the drug to improve the health of your eyes, you need to learn carefully and consult an ophthalmologist.
If you forget to take the medicine, when you remember the missed dose you should use the day. However, if the missed dose is close to the next dose, skip the missed dose and use the next dose. You should note that you should not double the dose, because this can cause bad symptoms affecting health.
Currently, there are no specific reports of patients using Loxoprofen drug overdose. However, if this happens, it can make symptoms and conditions worse. There is no antidote if an overdose of Loxoprofen occurs. However, the doctor may instruct the patient to drink activated charcoal or gastric lavage if the patient takes too much of it within 1 hour. It is also necessary to closely monitor the patient. In case of overdose, treatment methods are mainly focused on symptoms and support. In addition, it is possible to maintain fluid balance, ventilate and monitor cardiovascular and vital signs. If convulsions occur, anticonvulsants can be used if indicated, or bronchodilators can be used if asthma occurs.

In some cases when using the drug may experience unwanted side effects.
Common side effects: rash, edema, drowsiness, abdominal pain, upset stomach, nausea, vomiting, severe diarrhea and possibly even elevated liver enzymes. Rare side effects: such as peptic ulcer disease, leukopenia, eosinophilia, nervousness, increased alkaline phosphatase,... When experiencing side effects during drug use, patients should stop using the drug. use and notify the treating physician immediately. In case of serious side effects causing adverse reactions to the body, it is necessary to conduct supportive treatment such as using epinephrine, breathing oxygen, using antihistamines ...
Interactions of Loxoprofen with drugs other:
Loxoprofen should not be used in combination with aspirin, except for low-dose aspirin and must be prescribed by a doctor. It should not be used with other NSAIDs, as it may increase the risk of side effects for the user. Loxoprofen when combined with medicines containing corticosteroids may increase the risk of side effects in the gastrointestinal tract. Loxoprofen in combination with antihypertensives and diuretics may decrease the effectiveness of this medicine. Diuretics may increase renal kinetics. Combination with anticoagulants may potentiate the effects of warfarin. Combination with antiplatelet agents and selective serotonin reuptake inhibitors may increase the risk of gastrointestinal bleeding. Combination with cardiac glycosides may aggravate heart failure attacks, decrease glomerular filtration rate and increase plasma glycoside concentrations. Combination with Lithium may increase lithium plasma concentrations In combination with Cyclosporin, tacrolimus may increase the risk of nephrotoxicity. Combination with mifepristone may reduce the effect of mifepristone, especially between 8-12 hours after taking mifepristone. In addition, Loxoprofen should be used with caution in cases of diseases such as Crohn's disease, hypertension, infectious diseases or asthma and other allergic disorders...
Loxoprofen is indicated for use. in cases such as pain relief, anti-inflammatory treatment with symptoms of chronic rheumatoid arthritis, osteoarthritis, arthritis around the shoulder. To ensure effective treatment and avoid side effects, patients need to use prescription drugs or consult a doctor, pharmacist for advice.
Vinmec International General Hospital is a high-quality medical care address with a team of doctors and pharmacists with many years of experience and good expertise. When having health problems, customers can contact the hospital to be examined and have the best indications for taking medicine.