1. What is the use of A cnotren?
1.1. What is A cnotren?
A cnotren 10mg is manufactured by G.A Pharmaceuticals S.A. (GAP S.A.) - Greece, and is an indispensable choice for those who are suffering from severe acne, seriously affecting their health, especially the aesthetics of their skin, causing loss of confidence. A cnotren 10mg will help you quickly regain the best beauty for your skin.
Main ingredient Isotretinoin 10mg
Excipients: White beeswax, Butylated hydroxyanisole, Disodium edetate, Partially hydrogenated vegetable oil, Soybean oil, Gelatin, Glycerin, Sorbitol 76%, Carmoisin, Brilliant Blue, Pouceau 4R, Oxid iron den, Dioxyd titanium, Purified water.
1.2. What is the effect of A cnotren?
A Cnotren is effective in treating acne, helping the skin to be bright, clear and smooth.
A Cnotren is indicated for people with severe acne, especially effective for cystic acne.
Isotretinoin is effective in treating all types of acne, and reduces secretion and inhibits the activity of the sebaceous glands, thereby preventing the formation of scars.
A Cnotren is effective in fighting inflammation. Acne can cause severe inflammation and scarring. When inflamed, it leads to increased sebum secretion and irritation, creating scars.
2. How to use A cnotren
2.1. How to use A cnotren
A-Cnotren is used orally: Take the medicine with a glass of warm water to increase the absorption of the medicine, helping the treatment process achieve the best results. The medicine should be taken during meals and should not be taken with alcohol, beer, etc.
2.2. Dosage of A cnotren
Dosage for adults and children over 12 years old:
- Starting dose: 0.5 - 1 mg/kg/day, divided into 2 times for 15 - 20 weeks. Maximum: 2 mg/kg/day for very severe acne, acne on the chest or back.
- Maintenance dose: 0.1 - 1 mg/kg/day. Treatment should be stopped for 2 months before re-using.
- In severe refractory cystic acne, the dose may be increased to a maximum of 2 mg isotretinoin/kg body weight per day.
- For the treatment of keratinization disorders, the dose of isotretinoin may be increased to 4 mg isotretinoin/kg body weight per day.
Dosage for children under 12 years of age: Not for use in children under 12 years of age.
In patients with severe renal impairment, treatment should be initiated at a lower dose (e.g. 10 mg/day). The dose should then be increased to 1 mg/kg/day or until the patient receives the maximum tolerated dose.
Intolerant patients:
In patients who exhibit severe intolerance to the recommended dose, treatment may be continued at a lower dose with the consequent longer treatment duration and increased risk of relapse. To achieve the maximum possible effect in these patients, the dose should be continued at the highest tolerated dose.
Treatment for missed doses:
If the patient forgets a dose, the dose must be taken immediately. Note that the dose must not be doubled when the next dose is missed.
Treatment for overdose:
If the patient uses an overdose, the drug must be stopped immediately and the doctor must be informed to monitor the patient's condition. Some mild symptoms may appear and subside without treatment such as: nausea, vomiting, drowsiness, itching.
3. Contraindications of A cnotren
Do not use the drug in the following cases:
- Do not use blood from patients who have been using Isotretinoin for 1 month before to transfuse blood to women who are planning to become pregnant.
- Women who are pregnant or intend to become pregnant, women who have given birth and are breastfeeding.
- Women of childbearing age, unless effective contraception has been used.
- Patients with liver failure, patients with hepatobiliary disorders.
- Patients who overdose on vitamin A. Avoid using A Cnotren in combination with vitamin A because it can cause excessive vitamin A, increasing toxicity to the body.
- Patients with hyperlipidemia.
- Patients who are known to be sensitive to this drug or any ingredient of this drug.
- Alcohol can increase the risk of increased triglyceride levels, increased side effects and toxicity of isotretinoin.
- Isotretinoin can reduce serum Progesterone levels, leading to reduced contraceptive effect in patients using drugs containing progesterone.
- In addition, caution should be exercised when using A Cnotren with the following drugs: Doxycycline, Tetracycline, verteporfin, topical acne medications.
4. Notes when using A cnotren
4.1. Be careful when using the drug for
You need to carefully follow the instructions and dosage before using the drug. You also need to have a paraclinical examination for people with diabetes, obesity, lipid metabolism disorders in the body, and alcoholics. Avoid exposure to strong sunlight because UV rays can reduce the therapeutic effect of the drug and harm the skin. Patients must replace birth control pills containing Progesterone with other types. Due to the side effect of reducing vision, patients need to pay attention to the use of vehicles when using the drug.
4.2. Note for pregnant women and nursing mothers
A Cnotren is not recommended for pregnant women, because during pregnancy Isotretinoin can be harmful to the health of the fetus, causing the risk of fetal malformations and increasing the risk of miscarriage. For breastfeeding women: The ingredients in the drug will be excreted in breast milk and affect the baby, causing some unwanted side effects.
5. Side effects of A cnotren
Common:
- On the skin and mucous membranes:
- Frequent cheilitis
- Dry, irritated skin, especially on the face (facial dermatitis).
- Irritation of the conjunctiva, possibly complicating conjunctivitis - blepharitis or keratitis.
- Dry mucous membranes of the mouth, vagina, throat and nose, sometimes accompanied by nosebleeds and hoarseness.
- At the beginning of treatment, acne flare-ups may occur, which may last for several weeks.
Uncommon:
- Cases of rash, itching, erythema nodosum and vasculitis, increased eye pigmentation.
- Melasma on the face.
- Abnormal hair growth, mainly on the face.
- Increased sensitivity to sunlight.
- Hair loss or changes in degree (smaller), usually reversible after stopping the drug.
- Irritation of the urethra, blood in urine.
- Changes in the skin microflora, risk of local or systemic infection, especially due to Staphylococcus aureus.
- Staphylococcal granulomatosis in periungual lesions or lesions covered by acne.
- Nail dystrophy (foot, hand).
Rare:
- The skin becomes very fragile, which can lead to peeling, especially on the face after hair removal.
- Hypertrophic scars after dermabrasion.
- Cerebral edema causing nausea, vomiting, headache, visual changes.
Special cases:
Rare acne flares: Follicular lesions rapidly develop into inflammatory, purulent lesions, then ulceration - necrosis, often with systemic signs (fever, arthralgia, myalgia), and finally scarring. Treatment should be discontinued and systemic corticosteroids initiated.
6. How to preserve A cnotren
The expiry date printed on the packaging provided by the manufacturer is 36 months. To ensure the drug is safe for the longest time, customers need to store it in a dry, cool place, optimally in conditions below 30 degrees Celsius. It is best to store it in a sealed box, both to achieve low humidity and to ensure safety out of reach of children.
Users should store the drug in dry, cool places, not humid and at a temperature not exceeding 300C.
Do not put the drug in the freezer and limit all effects of strong light.
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