Prezel 75 is an anticonvulsant and analgesic medication, with the main active ingredient being pregabalin. To ensure effectiveness and minimize side effects, patients should take the medication according to the instructions provided by their physician or pharmacist.
1. Indications for Prezel 75
Prezel 75 is an anticonvulsant and analgesic with pregabalin as its primary ingredient. Prezel 75 is indicated for the following conditions:
- Peripheral and central neuropathic pain in adults.
- Adjuvant therapy in the treatment of focal seizures, with or without secondary generalized seizures in adults.
- Generalized anxiety disorder in adults.
2. How to Use Prezel 75
Method of Administration: Prezel 75 capsules are taken orally and may be taken with or without food.
- Dosage: The recommended dosage is between 150 to 600 mg per day, divided into two or three doses.
- Neuropathic pain: Start with a dose of 150 mg/day, divided into 2-3 doses, and may increase to 300 mg/day after 3-7 days of treatment.
- Epilepsy: Start with a dose of 150 mg/day, divided into 2-3 doses, and may increase to 300 mg/day after 1 week of use.
- Generalized anxiety disorder: 150 to 600 mg/day, divided into 2 or 3 doses. Regular evaluation of the patient's condition is advised.
- Liver Impairment: No dose adjustment required.
- Children: The safety and efficacy of pregabalin in children under 12 years old and adolescents (12-17 years old) have not been established. No available research data.
- Elderly (>65 years old): Elderly patients may require a dose reduction due to impaired renal function.
- Discontinuing pregabalin: According to current clinical guidelines, if discontinuation of pregabalin is necessary, it is recommended to gradually taper the dose over at least one week as per medical advice.
3. Contraindications for Prezel 75
Prezel 75 should not be used in the following patients:
- Patients who are allergic to pregabalin or any components of the medication.
- Children under 12 years old and adolescents (12-17 years old).
4. Cautions When Using Prezel 75
Caution should be exercised when using Prezel 75 in the following situations:
- Diabetic patients: Dose adjustment of antidiabetic medications may be required.
- Hypersensitivity reactions: There have been reports of hypersensitivity reactions, including cases of angioedema, after the drug became available. The medication should be discontinued immediately if symptoms such as angioedema, face swelling, swelling around the mouth, or upper respiratory swelling occur.
- Pregabalin treatment has been associated with dizziness and somnolence, which can increase the risk of accidents such as falls in elderly patients.
- Visual disturbances: In controlled clinical trials, blurred vision was reported more frequently in patients treated with pregabalin compared to those who received a placebo. Other visual disturbances, including transient blindness or blurred vision, have also been reported.
- Renal impairment: There have been reports of renal impairment, and in some cases, discontinuing pregabalin may alleviate adverse effects.
- Discontinuation symptoms: Symptoms such as insomnia, headache, nausea, diarrhea, flu-like symptoms, anxiety, stress, depression, seizures, pain, increased sweating, and dizziness. Seizures may occur during the use of Prezel 75 or immediately after discontinuation of the medication.
- Heart failure: Reports of heart failure have been observed in some patients treated with pregabalin.
- Suicidal thoughts and behaviors: These have been reported in patients treated with anticonvulsants. Therefore, patients should be monitored for signs of suicidal behavior, and appropriate treatment should be considered.
- Drug abuse: Caution is required in patients with a history of substance abuse. Patients should be monitored for signs of pregabalin misuse.
- Driving and operating machinery: Prezel 75 may impair the ability to drive or operate machinery. Since the medication may cause dizziness and somnolence, it is advised not to drive, operate machinery, or engage in dangerous activities while on the medication.
- Pregnancy: Prezel 75 should not be used during pregnancy unless absolutely necessary (if the therapeutic benefit to the mother outweighs the potential risk to the fetus).
- Women of childbearing potential: Due to unknown risks when using Prezel 75, women of childbearing age should use contraception if they are at risk of becoming pregnant.
- Breastfeeding: It is not clear whether the drug is excreted in breast milk. However, the drug has been detected in rat milk. Therefore, breastfeeding should be discontinued during pregabalin therapy.
5. Side Effects of Prezel 75
The most common side effects of Prezel 75 are dizziness and somnolence. Other side effects of the drug include increased bowel motility, mood elevation, confusion, irritability, reduced libido, disorientation, insomnia, lack of coordination, abnormal motor coordination, tremors, speech disturbances, memory impairment, attention deficits, paresthesia, sedation, vertigo, coma, headache, blurred vision, double vision, vomiting, dry mouth, constipation, bloating, erectile dysfunction, abnormal gait, drunkenness, fatigue, peripheral edema, swelling, and weight gain.
In summary, Prezel 75 is an anticonvulsant and analgesic medication with pregabalin as its primary ingredient. To ensure effectiveness and avoid side effects, patients should use the medication according to the instructions provided by their physician or pharmacist.
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