Uses of Azithromycin 200

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Azithromycin 200 is an oral bactericidal antibiotic commonly indicated in the treatment of respiratory tract, skin, genital tract infections... The following article will provide some information about the use of Azithromycin 200 as well as how to use it. safe use.

1. Uses of Azithromycin 200

Azithromycin is a broad-spectrum antibiotic belonging to the macrolide group of antibiotics. The drug has a strong bactericidal effect by binding to the ribosomes of pathogenic bacteria, preventing their protein synthesis. Azithromycin 200 is indicated in cases of infections caused by bacteria sensitive to the drug, including:
Respiratory tract infections caused by H. influenzae, S. pyogenes, M. catarrhalis, S. pneumoniae. Upper respiratory tract infections such as pharyngitis, tonsillitis, acute otitis media, acute sinusitis. Azithromycin is also used for acute exacerbations of chronic obstructive pulmonary disease, community-acquired pneumonia. Skin infections caused by S. pyogenes, S. aureus or S. agalactia (Streptococcus group B). Sexually transmitted infections: Chlamydia caused by Haemophilus ducreyi; non-gonococcal urethritis; uncomplicated gonorrhea caused by non-multiresistant N. gonorrhoeae. Chlamydia trachomatis infection : Pneumonia in children; trachoma ; infection with C. trachomatis in the genitourinary system; acute inflammation of organs in the pelvis. Legionella pneumophila infection. Mycobacterium avium complex infection (MAC): Treatment of pulmonary MAC infection in HIV-negative adults; primary prevention, treatment and prevention of recurrence of disseminated MAC infection. Prophylaxis of infective endocarditis caused by Viridans group hemolytic streptococci in penicillin-allergic subjects. Whooping cough caused by Bordetella pertussis.

2. Contraindications of Azithromycin 200

Do not use Azithromycin 200 for patients with hypersensitivity or allergy to Azithromycin, Erythromycin, any antibiotic of the Macrolide or Ketolide group and to the excipients in the drug.
Oral azithromycin is not used for outpatient treatment of moderate and severe pneumonia, patients at risk of hospital-acquired infections and immunocompromised patients. These cases require inpatient treatment at the hospital.
Caution and note when using Azithromycin 200 for the following subjects:
Be careful in patients with liver failure, liver function is damaged because Azithromycin is mainly eliminated through the liver. Dosage adjustment is appropriate for patients with renal impairment with creatinine clearance > 40 ml/min. Not to be used in patients with renal failure with a glomerular filtration rate less than 10 mL/min. Superinfection: As with any other antibiotic, it is important to monitor for signs of superinfection with non-susceptible organisms, including fungi. Clostridioides difficile-associated diarrhea: Has been reported for most antibacterial agents, including azithromycin, ranging in severity from mild diarrhea to colitis and death. This disease should be considered in all patients who develop diarrhea after taking antibiotics. Diabetic patients: Azithromycin 200mg contains sucrose, should not be used in patients with fructose intolerance, sacharase-isomaltase deficiency, glucose-galactose malabsorption. Prolonged QT interval: Although there are no reports of clinical trials, however, when using Macrolide antibiotics, including Azithromycin, it has been found that the drug prolongs the QT interval, causing a risk of arrhythmia, torsades de pointes, and arrhythmias. fast failure. Caution should be taken when using the drug in patients with cardiovascular disease, especially patients with electrolyte disturbances, bradycardia, arrhythmias, the elderly, taking antiarrhythmic drugs, QT prolongation. congenital or acquired. Pregnancy: There are currently no adequate data on the use of Azithromycin in pregnant women, use Azithromycin 200 only when there is no other more appropriate drug option. Lactation: Azithromycin passes into breast milk and should be used with caution in this population.

3. Undesirable effects when using Azithromycin 200

Azithromycin is a well-tolerated drug with a low rate of adverse events with approximately 13% of people taking the drug. Side effects include:
The most common undesirable effect is gastrointestinal disorders (about 10%): Nausea, abdominal pain, vomiting, diarrhea. Less common are flatulence, loss of appetite, and indigestion, however they are usually mild. Systemic symptoms may include headache, fatigue, dizziness, somnolence. Slight decrease in the number of neutrophils in the blood. Increased liver enzymes (AST and ALT). Hearing Effects: Long-term use of high doses of Azithromycin 200 may cause reversible hearing loss in some patients. Skin symptoms: Rash or itching. Vaginitis, cervicitis. Rarely serious allergic or hypersensitivity reactions, such as angioedema or anaphylaxis. Symptoms usually resolve on discontinuation of the drug. However, allergic symptoms may recur after discontinuation of initial symptomatic treatment. For severe allergic reactions, long-term patient monitoring and symptomatic treatment is required.
The majority of adverse events are mild or moderate in severity and are reversible upon discontinuation of the drug. Azithromycin 200 oral mixture can be used with food to improve tolerability.

4. How to take Azithromycin 200

Mix Azithromycin 200 with enough water, about 5-10ml of water for 1 pack, stir well before drinking. Azithromycin 200 is taken once daily, 1 hour before meals or 2 hours after meals.
Dosage below is for reference only. The specific dosage for each patient depends on the condition and the progression of the disease, it is best to consult your doctor.
Dosage for adults:
Infections of the respiratory tract and skin: Take 500mg as a single dose on day 1, 250mg x 1 time per day on days 2-5, total 1.5g for 5 days. Genital tract infections caused by Chlamydia trachomatis, Haemophilus ducreyi: A single dose of 1000 mg. Non-multi-resistant Neisseria gonorrhoeae : Use when no other better drug is available, single dose 2000mg. Do not use a lower dose. Leptospira disease: A single dose of 1g on the first day, 500mg/time/day for the next 2 days. A dose of 15mg/kg/day can be divided into 2 doses for 7 days. Prophylaxis of Mycobacterium avium complex infection in HIV-infected patients: Oral 1200mg x 1 time/week. Treatment and prevention of recurrence of disseminated Mycobacterium avium complex infection in HIV patients: 600 mg x 1 time/day, in combination with ethambutol: 15 mg/kg/day, antifungal drugs can be used. Whooping cough: The first dose is 500mg x 1 time/day 1, day 2 to day 5: 250mg/time/day. Prophylaxis of infective endocarditis (in patients allergic to penicillin): 500mg single dose 30-60 minutes before surgery. Dosage for children:
Pharyngitis, tonsillitis caused by S.pyogenes (group A beta-hemolytic streptococcus) for children from 2 years of age and older: 12mg/kg/day orally 1 single dose, taken for 5 days day. Acute otitis media for children from 6 months of age: the first day 10mg/kg/time/day; day 2 to day 5: use 5mg/kg/day/1 time. Prophylaxis of infective endocarditis: 15mg/kg, used 1 hour before surgery. Community-acquired pneumonia for children from 6 months old: day 1: 10mg/kg (maximum 500mg) orally once; day 2 to day 5: use 5mg/kg/time/day (maximum 250mg/day).

5. Azithromycin 200 . drug interactions

Azithromycin 200 may interact with the following substances and drugs:
Erectile dysfunction: Concomitant use with Azithromycin increases the risk of ergot poisoning. Antacids: Take Azithromycin 200 at least 1 hour before or 2 hours after taking an antacid. Digoxin, Cyclosporin: Because Azithromycin affects the metabolism of these drugs. Monitor and adjust the dose if necessary when taking these drugs simultaneously. Coumarin-type anticoagulants: The anticoagulant time of the patient must be monitored when co-administered with Azithromycin. Rifabutin: When used in combination with Azithromycin, it increases the neutropenic effect. In summary, Azithromycin 200 is a prescription drug indicated in the treatment of infections of the respiratory tract, skin, genital tract... To ensure safety and effectiveness, patients need to use it according to the indications and instructions of the doctor. doctor

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