Uses of Lofacef

Lofacef medicine contains active ingredients Paracetamol and Tramadol with analgesic effect. So how should the drug be used properly and what precautions should be taken when using it? Please read the article below

1. What is Lofacef?

Lofacef medicine contains the main ingredient of 325mg Paracetamol and 37.5mg Tramadol lydrochloride in the form of film-coated tablets. In which, Tramadol is a drug with central analgesic effect with 2 mechanisms including binding of parent substance and active metabolite (M1) with Mu-opioid receptor and slight inhibition of reabsorption of norepinephrine and serotonin.
On laboratory evaluations, the combination of Tramadol and Paracetamol shows a synergistic effect with effective analgesic effect. Lofacef is indicated for the treatment of moderate to severe pain.
It should be noted that it should not be prescribed to women who are breastfeeding because there has not been a complete study on the effects of the drug on this subject so far.

2. Instructions for using Lofacef

Adults and children over 12 years old use a maximum dose of 1 to 2 tablets every 4 to 6 hours, not more than 8 tablets / day. Children under 12 years of age need to consult a doctor before using the drug because there are no accurate studies on the dosage for this subject.

3. Side effects of the drug Lofacef

Side effects often occur on the central nervous system and digestive system, the most common of which are dizziness, nausea, drowsiness.
There are also some less common reactions such as:
Body weakness, fatigue. Headache, trouble sleeping. Abdominal pain, diarrhea, constipation, indigestion, flatulence, vomiting, dry mouth. Psychiatric disorders with manifestations of anorexia, anxiety, agitation, restlessness, insomnia. Itching, increased sweating, rash.

4. Interactions between Lofacef and other drugs

When using Lofacef at the same time with some of the following drug classes, drug interactions may occur such as:
MAO inhibitors and serotonin reuptake inhibitors: Concomitant use with MAO inhibitors or inhibitors inhibiting serotonin reuptake increases the risk of side effects such as seizures and serotonin syndrome.
Carbamazepine: Concomitant use of Tramadol hydrochloride ingredient with Carbamazepine increases the metabolism of Tramadol, while reducing the analgesic effect of Tramadol.
Quinidine: Tramadol will be converted to M1 by CYP2D6, so taking quinidine with tramadol may increase the concentration of Tramadol.
Warfarin group: In some patients, an increase in INR was noted. Therefore, periodic evaluation of the extrinsic clotting time is necessary when these drugs are co-administered.

5. Some notes when using Lofacef

When using Lofacef, it is necessary to pay attention to the following issues:
When using tramadol concurrently with drugs that inhibit serotonin reuptake, Opioid drugs, MAOIs, sedatives or drugs that lower the threshold convulsions. Caution should be exercised in patients with a history of epilepsy, convulsions or at risk of convulsions. Use with caution in patients at risk of respiratory failure. Caution should be exercised when co-administering drugs with central nervous system depressant effects such as alcohol, opioids, anesthetics, anesthetics, hypnotics and sedatives. Above is all information about Lofacef drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before use. Absolutely do not arbitrarily buy Lofacef treatment at home because there may be unwanted side effects.

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