Uses of Ribotacin

Ribotacin is used in the following cases:
Treatment of severe infections of the lower respiratory tract including pneumonia. Treatment of skin and soft tissue infections. Treatment of bone and joint infections. Treatment of severe urinary and genital infections. Treatment of bacteremia and meningitis caused by susceptible bacteria. Treatment of disseminated gonorrhea infection without complications. Prophylaxis of infection after surgery. Ribotacin should not be used in the following cases:
Patients with hypersensitivity to Cephalosporins or to any of the excipients in the drug. Patients with a history of allergy to any Beta lactam.

2.1. How to use Solvent for intramuscular and intravenous injection: Distilled water for injection. Solvent for continuous intravenous infusion: 0.9% sodium chloride injection, 5% dextrose injection, 10% dextrose injection, 5% dextrose injection and 0.9% sodium chloride injection, 5% dextrose injection and sodium chloride injection. chloride 0.45%, or sodium lactate M/6 injection. Intramuscular injection: Add 3ml of distilled water for injection to 750mg of Ribotacin, then shake gently, the solution will be light yellow. Intravenous injection: Dissolve Ribotacin in distilled water for injection at least 6ml for 750mg, then shake gently, the solution will be light yellow. Intravenous infusion: For short intravenous infusion (eg up to 30 minutes), 1.5g can be dissolved in 50 mL of distilled water for injection. These solutions can be injected directly into a vein or through the tubing of an infusion set if the patient is receiving fluids. 2.2. Dosage Adults: The usual dose is 750mg of Cefuroxime, every 8 hours, but in more severe infections 1.5g of Cefuroxim can be given intravenously every 8 or 6 hours. Children and very young children: 30mg to 60mg Cefuroxim/kg body weight/day, if necessary can increase to 100mg Cefuroxim/kg/day, divided into 3-4 small doses. In case of renal impairment: It may be necessary to reduce the injection dose. When creatinine clearance is in the range of 10 to 20 ml/min, the usual adult dose of cefuroxime is 750 mg every 2 hours. When creatinine clearance is less than 10ml/min, use the usual adult dose of 750mg Cefuroxime once daily. For patients on hemodialysis, a dose of 750mg Cefuroxime should be given at the end of each dialysis session. In patients undergoing routine arterial-venous dialysis and periodic peritoneal dialysis, the appropriate dose is usually 750mg Cefuroxime twice daily. Hepatic impairment: Cefuroxime is mainly eliminated by the kidneys, so the drug is not affected in patients with hepatic impairment. Meningitis caused by susceptible strains of bacteria: Adults, intravenous dose of 3g Cefuroxime, every 8 hours; children and very young children, intravenous dose of 200-240 mg Cefuroxime/kg body weight/day, divided into 3 or 4 small doses; After 3 days or when there is clinical improvement, the intravenous dose can be reduced to 100mg Cefuroxime/kg body weight/day. Neonates, given intravenous injection of 100 mg Cefuroxim/kg/day, the dose may be reduced to 50 mg Cefuroxim/kg/day when clinically indicated. Gonorrhea: Use a single dose of 1.5g Cefuroxime. Can be divided into 2 injections of 750mg Cefuroxime into different sites, eg into the buttocks. Prophylaxis of surgical infections: The usual dose is 1.5g of Cefuroxim intravenously before surgery, then continue intravenously or intramuscularly at 750mg of Cefuroxim, every 8 hours for a period of 24 to 48 hours. after. In total joint replacement, 1.5g of Cefuroxime can be mixed with methyl methacrylate cement.

Ribotacin when used in combination with some of the following drugs may occur drug interactions such as:
High dose probenecid combined with Ribotacin reduces renal clearance of cefuroxime, making cefuroxime plasma concentrations taller and longer. Cefuroxime may decrease the effectiveness of oral contraceptives. Concomitant use with vitamin K antagonists may increase the INR. Aminoglycosides may increase the likelihood of kidney toxicity. Strong diuretic. To ensure safety when using Ribotacin treatment, patients should tell their doctor or pharmacist all the medicines they are taking and any other medical conditions they are having.

During the use of Ribotacin, patients may encounter some unwanted side effects (accounting for about 3%) as follows:
Common: Painful and burning injection site, thrombophlebitis at the injection site , diarrhea ... Uncommon: Hypersensitivity + anaphylaxis, Candida infection, leukopenia, eosinophilia, neutropenia, positive Coombs test... Rare: Deficiency hemolytic anemia, Stevens - Johnson syndrome, erythema multiforme and toxic epidermal necrolysis, headache, convulsions, agitation.

There have been reports on studies using Ribotacin in mice and rats with no evidence of effects on fertility or harm to the fetus. There are data indicating that cefuroxime is excreted in breast milk at low concentrations, with no effect on the nursing infant. However, if your child has diarrhea, rash, and thrush, they should take medicine and consult a doctor or pharmacist. Ribotacin does not affect the ability to drive and use machines.