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Alsiful 10mg drug contains the active ingredient Alfuzosin, indicated in the treatment of symptoms of benign prostatic hypertrophy and acute urinary retention. So how to use Alsiful effectively will be answered through the article below.1. Uses of Alsiful 10mg
1.1. Point
What is Alsiful? Alsiful medicine 10mg contains the active ingredient Alfuzosin, which is indicated in the treatment of symptoms of prostatic hypertrophy and acute urinary retention due to prostate enlargement.1.2. Pharmacodynamic
Alfuzosin is an active quinoline derivative for oral administration. The drug has a selective effect on peripheral alpha-1 receptors in the prostate, urethra and bladder. Studies have demonstrated the effects of Alfuzosin as follows:The drug increases the peak flow rate (Qmax) significantly in patients with Qmax ≤ 15ml/s, the average increase is about 30%. Significantly the extrusion pressure and volume, thereby increasing the urge to urinate The drug significantly reduces the residual urine volume The above effects of Alfuzosin make Alsiful effective for improving symptoms of diabetes lower urinary tract (symptoms of obstruction, irritation). In addition, the drug also has a moderate effect on lowering blood pressure.
1.3. Pharmacokinetics
Alfuzosin is available as a delayed-release tablet. The drug is well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached about 9 hours after oral administration, with a half-life of 9.1 hours. The drug is strongly bound to plasma proteins (about 90%).Metabolism of the drug is extensive and only about 11% of the original drug is excreted unchanged in the urine. Approximately 75-91% of Alfuzosin's metabolites are excreted in the feces. The liver enzyme CYP3A4 plays a major role in the metabolism of Alfuzosin.
2. Dosage of Alsiful 10mg
2.1. How to use
Alsiful is taken as a whole tablet with the dose prescribed by the doctor (the usual dose is 1 tablet / time / day). The drug works best when taken with meals. Therefore, patients should not take Alsiful on an empty stomach because of the risk of reducing the drug's effect.Do not break or chew the tablet as it may release the medicine all at once, increasing the risk of side effects.
2.2. Dosage
Dosage of Alsiful 10mg depends on each patient and as prescribed by the treating doctor. Dosage recommendations are as follows:Treatment of benign prostatic hypertrophy: Take 1 tablet/time/day after meals; Treatment of acute urinary retention: In patients aged 65 years and over, the dose is 1 tablet/day x 3-4 days.
3. Side effects
Some side effects may be encountered when using Alsiful 10mg as follows:Common side effects: Headache, dizziness, abdominal pain, nausea, weakness Uncommon side effects: Drowsiness, fatigue , tachycardia, visual abnormalities, hypotension, palpitations, rhinitis, syncope, diarrhea, vomiting, dry mouth, itching, facial flushing, chest pain, edema;
4. Note when using
4.1. Contraindications
The use of Alsiful 10mg is contraindicated in the following cases:Patients are sensitive to any ingredient of Alsiful 10mg; Patients with a history of orthostatic hypotension; Contraindicated use in combination with alpha receptor blockers; Patients with liver failure.
4.2. Note when using
Alsiful should be used with caution in patients with severe renal impairment, and should not be used in patients being treated with antihypertensive drugs (regular blood pressure monitoring is required).Ability to drive and operate machines: Alsiful may cause debilitating side effects, dizziness, so caution should be exercised when driving or operating machinery.
Pregnant women, lactating women: Do not use the drug in these subjects.
5. Drug interactions
Alsiful 10mg is contraindicated in combination with alpha-1 receptor blockers.Caution when used with nitrate drugs, antihypertensive drugs, strong inhibitors of CYP3A4 such as itraconazole, ketoconazole, ritonavir.
Alsiful drug does not interact with drugs digoxin, warfarin, atenolol, hydrochlorothiazide.
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