Uses of Istrax

Istrax belongs to the group of antiparasitic, anti-infective, antiviral, and antifungal drugs used to treat fungal infections. Below is detailed information about what Istrax is and what precautions to take.

Istrax medicine is made in the form of capsules, the main ingredient is Itraconazole 100mg. Itraconazole is an oral antifungal drug, a derivative of triazole, with a broad spectrum of antifungal activity, inhibiting the growth of many fungi causing human diseases such as dermatophytes (strains of Trichophyton spp., Epidermophyton floccosum, Microsporum spp.,) , yeast (Candida strains including C. albicans, C. krusei, C. glabrata), Cryptococcus neoformans, Pityrosporum spp., Trichosporon spp., Aspergillus spp., Geotrichum spp., Histoplasma spp., Paracoccidioides brasiliensis, Sporothrix schenckii, Cladosporium spp., Fonsecaea spp., Blastomyces dermatitidis, Penicillium marneffei, Pseudallescheria boydii and other fungi. Candida strains less susceptible to the drug are C. glabrata and C. tropicalis. The fungi that are not inhibited by itraconazole are Fusarium spp., Zygomycetes (Rhizopus spp., Rhizomucor spp., Absidia spp., Mucor spp.), Scedosporium spp. and Scopulariopsis spp. Itraconazole disrupts the synthesis of ergosterol - an essential component of the fungal cell membrane, from which the drug has an antifungal effect. Itraconazole is rapidly absorbed after oral administration, with peak concentrations occurring 2 to 5 hours after oral administration.

Istrax is used in the following cases:
Candida infections of the mouth - throat, vulva - vagina Ringworm infections: Fungal infections of the fingers, skin of the feet, nails, toenails, groin. Lang Ben . Visceral fungal infections caused by Aspergillus, Candida, Cryptococcus, Histoplasma, Paracoccidioides, Sporothrix, Blastomyces. In patients with HIV/AIDS: Maintenance therapy to prevent recurrence of latent fungal infections. Prophylaxis of fungal infections when neutrophil counts are prolonged.

Do not use Istrax in the following cases:
People with hypersensitivity to Itraconazole or other azole drugs. The drug should not be used by pregnant or lactating women, only used when visceral fungal infection is life-threatening, carefully weighing the benefits of treatment against the risk of harm to the fetus. Do not use concomitantly with terfenadine, astemizol, cisapride, midazolam and oral triazolam.

Dosage depends on each case and should be taken immediately after meals.
Vaginal - vaginal candidiasis: Take 2 tablets x 2 times/day, use for 1 day; or 2 tablets / time / day for 3 days. Ringworm: Take 2 tablets/time/day for 7 days. Ringworm: Take 2 tablets/time/day for 7 days or 1 tablet/time/day for 15 days. Highly keratinized areas such as fungal infections of the soles and palms: Take 2 tablets x 2 times / day for 7 days or 1 tablet / time / day for 30 days. Oral - pharyngeal candidiasis: 1 capsule/time/day for 15 days. People with AIDS, neutropenia or organ transplant: Take 2 tablets/time/day for 15 days. Toenail fungus: Drink 2-3 times, 7 days/time, take 4 tablets 2 times a day. Each course of treatment is separated by 3 weeks or continuously 2 tablets / time / day for 3 months. Visceral fungal infections: Aspergillus infections: Take 2 tablets/time/day for 2-5 months, if the disease does not improve, the dose can be increased to 2 tablets x 2 times/day. Candida infection: Take 1-2 tablets/time/day for 3 weeks to 7 months. Epidural Cryptococcus infections: Take 2 tablets once a day for 2 months to 1 year. Cryptococcal meningitis: take 2 tablets x 2 times/day, maintenance treatment: Take 2 tablets/time/day. Histoplasmosis: Take 2 tablets x 1-2 times/day for 8 months. Sporothrix schenckii infection: Take 1 tablet once a day for 3 months. Paracoccidioides brasiliensis infection: 1 tablet/time/day for 6 months. Chromomycosis (Fonsecaea, Cladosporium): 1-2 tablets/time/day for 6 months. Blastomyces dermatitidis infection: 1 tablet / time / day or 2 tablets x 2 times / day for 6 months.

When using Istrax, you may experience some of the following undesirable effects:
Headache, nausea, indigestion, abdominal pain. Uncommon: Allergies, pruritus, rash, urticaria, angioedema, Stevens-Johnson syndrome, menstrual disorders, reversible elevation of liver enzymes. Rare: Hypokalemia. When using Istrax, if the patient experiences any serious side effects, stop taking the drug and immediately contact the treating doctor or go to the nearest medical facility for timely treatment.

When combined with Istrax may interact with the following drugs:
Do not use Itraconazole concurrently with drugs such as terfenadine, astemizol, cisapride due to increased plasma concentrations of these drugs, prolongation of the QT interval and rarely torsades de pointes may occur. Do not use concomitantly with oral drugs midazolam and triazolam.

When using Istrax, caution should be exercised in the following cases:
Itraconazole is metabolized mainly by the liver, the half-life of the drug is prolonged when used in patients with cirrhosis. Therefore, it should be used with caution in people with a history of liver disease, monitoring liver function when taking the drug for a long time. Should not be used by women who are pregnant or breastfeeding. In addition to the above information, if you have any questions about Istrax, you can contact your doctor for advice and answers.