What are the uses of Staga 50?

Staga 50 is used in men with conditions such as erectile dysfunction, physiological weakness, premature ejaculation, spermatogenesis, ... When using the drug, patients need to adhere to the recommended dosage. to avoid unwanted side effects.

Staga 50 drug has the main ingredient is Sildenafil citrate, indicated for use in cases of erectile dysfunction, spermatozoa, premature ejaculation and physiological weakness in men. In addition, S taga 50 is also used to help increase the relationship time for couples.

Staga 50 is available as a film-coated tablet, in which one side has a broken line and the other is smooth. Each Staga 50 tablet contains the following ingredients:
Main ingredients: Sildenafil (50 mg strength); Other excipients: Lactose, Crospovidone, Microcrystalline cellulose, Magnesium stearate, Povidon K30,... just enough for one tablet.

3.1. Staga 50 Pharmacodynamics Staga 50 is the citrate salt form of Sildenafil, commonly used by mouth to help treat erectile dysfunction in men. The ingredient sildenafil in the drug has the ability to selectively inhibit cyclic guanosin monophosphate - specific phosphodiesterase type 5 (PDE5).
During sexual stimulation, the physiological mechanism of penile erection is accompanied by the release of nitric oxide (NO) in the corpus cavernosum, which activates the enzyme guanylate cyclase to increase the concentration of cGMP (cyclic guanosine monophosphate). . As a result, the vascular smooth muscle of the corpus cavernosum is relaxed and promotes blood flow to the penis. This helps men prolong the time of penile erection as well as sexual intercourse.
Sildenafil ingredient in Staga 50 has the ability to increase the effect of nitric oxide through inhibiting PDE5 - the substance that helps to break down cGMP in the corpus cavernosum. During sexual stimulation, NO will be released locally along with inhibition of PDE5 causing cGMP content to increase, thereby relaxing smooth muscle and helping blood flow to the corpus cavernosum better.
Pharmacokinetics The pharmacokinetics of the Sildenafil component of Staga 50 will be dose proportional within the recommended dose range. The absolute bioavailability of Sildenafil averages about 41%, which is rapidly absorbed after oral administration. Sildenafil is centrally distributed to tissues, with a mean volume of distribution of 105 L.
Once absorbed and distributed into tissues, Sildenafil is metabolised by the hepatic enzymes CYP3A4 and CYP2C9. Through N-desmethylation, major metabolites of Sildenafil are generated and the metabolism continues. The half-life of the N-desmethyl metabolite is usually within 4 hours.
At the end of metabolism, Sildenafil will be excreted in the feces as metabolites (accounting for about 80% of the oral dose) and a small amount in the urine (accounting for about 13% of the oral dose). The total clearance of Sildenafil is 41 L/hr, where the terminal half-life is 3 – 5 hours.
3.2. Indications of the drug Staga 50 Staga 50 is indicated for use in men in the following cases:
Treatment of erectile dysfunction (the inability to maintain or achieve an erection of the penis to satisfy the sexual activity); Used for men who want to prolong sex; Men with spermatozoa, premature ejaculation or physiological weakness.

For Staga 50 to be highly effective, you need to follow the following specific dosage and usage recommendations:
4.1. Dosage of Staga 50 For adults: Adult men should take the usual dose of 50 mg (equivalent to 1 tablet/time) and take it 1 hour before sexual activity. The dose can be reduced to 25 mg or increased to a maximum of 100 mg depending on the tolerability as well as the effect of the drug. However, the general recommended dose according to the doctor is a maximum of 100 mg / time / day.
*For children: Do not use Staga 50 for children under 18 years old.
*For the elderly: No dosage adjustment is required.
*For patients with hepatic impairment: Because clearance of the drug is reduced in subjects with hepatic impairment or cirrhosis, the recommended dose for this subject is 25 mg.
*For patients with renal impairment: Creatinine clearance is between 30 - 80 mL/min, so people with mild to moderate renal impairment can take the usual dose without any adjustment. For severe acute renal failure and creatinine clearance less than 30 mL/min, a dose of 25 mg is recommended.
*Note: The above dosage is for reference only, so patients need to discuss carefully with their doctor to get a dose suitable for their condition and progression of the disease.
4.2. How to use Staga 50 for high effectiveness Staga 50 is used orally. You can swallow the tablet whole with water, but avoid drinking it with carbonated water, soft drinks or alcoholic beverages because it can reduce the effect of the drug.
You can break the pill in half to divide the dose and should use it about 1 hour before sex. When using Staga 50, you need to limit the consumption of fatty foods because they can interfere with the body's absorption of the drug. Staga 50 will bring the best effect if men follow a reasonable diet, and combine exercises to enhance physiology.

Staga 50 is mainly used when there is a need and does not need to be taken on a regular schedule. An overdose of the drug (800 mg sildenafil) can lead to side effects similar to those at low doses, but the frequency and severity will increase.
If you notice that your body has an abnormal reaction after taking an overdose, the patient should immediately go to a medical facility for monitoring and timely support measures. In fact, because the Sildenafil component is tightly bound to plasma proteins, and moreover, they are not eliminated in the urine, so renal dialysis does not increase clearance.

Staga 50 is not recommended for the following people:
Women; People who are allergic to Sildenafil or hypersensitive to other ingredients of the drug; Male under 18 years old; Men are at higher risk of cardiovascular disease, heart events or stroke ; Men with severe liver or kidney failure; Men with hereditary retinal degenerative disorders; Men with monocular vision loss due to anterior ischemic optic neuropathy; People with low blood pressure; People taking organic nitrates or nitric oxide donors such as sodium nitroprusside, glyceryl trinitrate (nitroglycerin), and amyl nitrite.

According to research, the rate of patients experiencing side effects of the drug will increase when used in high doses. Most adverse reactions after administration of Staga 50 were transient, with the most common symptoms being headache, facial flushing, dyspepsia, nausea, nasal congestion, dizziness, blurred vision or astigmatism.
Some less common side effects of Staga 50, including:
Gastroesophageal reflux, dry mouth, upper abdominal pain and vomiting; Rhinitis, rash or allergies; Nosebleeds, sinus congestion; Photophobia, glare, eye pain or eye congestion; Lower blood pressure; Palpitations, heart palpitations; Extremity headache, muscle pain; Hypersensitivity reactions or generalized hot flashes. In rare cases, users of Staga 50 may experience the following undesirable symptoms:
Seizures , fainting; Eye swelling, eye oedema, dazzle, erythrophobia, yellow pallor, conjunctival congestion, eye disorder, eyelid edema, eye pruritus; Nasal swelling, dry nose or dry throat; Decreased oral sense of touch; Whole body itching; Erectile dysfunction, prolonged penile pain; Cardiovascular disorders such as angina pectoris, myocardial infarction, cerebrovascular accident, ventricular arrhythmia, etc. When they notice any noticeable symptoms after taking Staga 50, patients need to hurry up. Immediately go to the nearest hospital or medical facility for timely treatment. Delayed detection and treatment will lead to serious health complications for the patient.

Staga 50 may enhance the hypotensive effect of nitrates, such as Isosorbide mononitrate (Isno, Monoket, Imdur); Isosorbide dinitrate (Isordil), nitroglycerin (Transderm-Nito, Nitro-Dur). Therefore, men should not take Staga 50 with these drugs, especially Nitroglycerin.
In addition, drugs such as Itraconazole, Ketoconazole, Erythromycin, Cimetidine,... can reduce the elimination ability of Staga 50 when used in combination. Patients should also consult their doctor if taking Sildenafil with other protease inhibitors. Medicines such as Bosentan, antiviral drugs (Saquinavir, Ritonavir) or Rifampicin can reduce the effectiveness of Sildenafil, so caution should be taken when used concurrently.

9.1. Note when taking Staga 50 Staga 50 should be used according to the dose prescribed by the doctor, so the patient should not increase or decrease the dose arbitrarily to avoid dangerous risks to health. In addition, users should only open tablets when they have a need to drink, avoid leaving the medicine outside in the air for too long.
For those who have a history of diseases such as heart disease, stroke, etc., it is necessary to notify the doctor before taking the drug to know whether to continue using or switch to another suitable drug. more or not. In addition, before taking Staga 50, you need to carefully check the expiry date and condition of the drug. Should be thrown away immediately if you see signs of mold, broken or torn,...
Pregnant and breastfeeding women should not use Staga 50, because this drug is only applicable to men. In the event of an accidental overdose, the patient should proactively notify the doctor for timely treatment.
Staga 50 also needs to be used with caution in men who have a job such as driving or operating machinery. This medicine may cause dizziness, headache, or vision loss. In the process of taking the drug, you also need to limit the use of stimulants such as alcohol, coffee to avoid affecting the effectiveness of the drug.
9.2. Drug storage conditions Staga 50 should be stored in a cool, dry place, away from direct light. The right temperature that does not affect the quality of the medicine is below 30 degrees Celsius. You also need to store the medicine out of the reach of children, it is best not to use the medicine that has melted, expired or molded.
Above is information to help you understand Staga 50 and the notes when using it. To ensure safety for health and maximize the effectiveness of treatment, the use of drugs must follow the instructions of a qualified doctor.