Diazepam 5mg is a drug containing the ingredient diazepam, which is relatively common for mental health problems such as anxiety, insomnia, prolonged stress, agitated mood... So what is Diazepam 5mg and what is the dose? The article below will help readers gain more knowledge related to Diazepam.
1. General information about the drug Diazepam 5mg
Diazepam is a drug belonging to the 1.4 benzodiazepine group of psychotropic drugs with the ability to improve stress, anxiety and agitation significantly, and is used as a sedative to help sleep well. Besides, Diazepam 5mg also has benefits against convulsions and helps relax muscles. Because of these effects, Diazepam is often prescribed for short-term treatment of long-term stress and anxiety problems and acts as a pre-anesthetic drug as well as a local treatment for detoxification activities alcohol.
According to scientists' explanations, when Diazepam enters the body, it will bind to specific receptors in the central nervous system as well as special peripheral organs, forming benzodiazepine receptors. These receptors will function closely with the receptors of the Gamma Aminobutyric Acid (abbreviated as GABA) transmission system. Thanks to this activity, the GABA transmission system will be inhibited.
On the market today, in addition to Diazepam 5mg tablet form, Diazepam medicine also has many other forms/ concentrations, including:
• Diazepam 2mg tablet form.
• Diazepam 10mg tablet form.
• Diazepam is a solution for injection with a concentration of 5mg/ ml or 10mg /2 ml.
2. Pharmacokinetics of Diazepam
The best way to absorb
Diazepam is through the digestive tract, because this is the way to help the body completely absorb Diazepam. During about 30 minutes to 2 hours after using the drug, Diazepam plasma concentrations will increase rapidly. Besides through the digestive tract, Diazepam 5mg can also be transmitted into the body in other ways such as:
• Intramuscular injection: depending on the injection site, the speed and amount of diazepam absorbed by the body will be different.
• Deltoid muscle injection: diazepam absorption rate is fast, in most cases the drug is completely absorbed.
• Rectal enema: diazepam can also be administered via anal enema with a relatively fast absorption rate, while also ensuring almost complete absorption of the drug.
When entering the body, Diazepam will quickly bind to plasma proteins with a distribution volume of about 0.95 - 2 liters per kg of body weight and the patient's current age when taking the drug. In particular, Diazepam is a lipophilic substance, so it will quickly move and mix into the cerebrospinal fluid. Besides, Diazepam and some main metabolites will go to the placenta and be excreted through breast milk.
In the body, Diazepam 5mg is metabolized mainly in the liver. After this process, Diazepam will convert into many metabolites such as N-desmethyl diazepam (or nordiazepam), oxazepam and temazepam found in urine in the form of glucuronide. However, only about 20% of these pharmacologically active metabolites exist in the urine during the first 72 hours.
After being absorbed, Diazepam will be excreted mainly through the kidneys and partly through bile depending on the functions of the two organs, as well as the patient's age.
For infants, the metabolism and elimination of diazepam will take place much slower than in children and adults. For the elderly, the drug also has a metabolism + elimination rate of 2 to 4 times that of young people. Elimination of diazepam is also prolonged in patients with impaired kidney or liver function.
3. Diazepam 5mg and precautions during use
Diazepam 5mg should be used with special caution when used by people with liver and kidney function problems, lung disease, angle-closure glaucoma or brain damage, arteriosclerosis... In addition, Diazepam 5mg or other types of Diazepam in general are contraindicated for the following target groups:
• Patients with myasthenia or severe respiratory failure.
• The patient is in a state of fear and phobia.
• Do not use medication to treat depression/anxiety combined with depression alone, as Diazepam may increase the risk of suicide in this patient group.
• Do not use the drug to treat patients with chronic psychosis, amnesia, or in cases the patients who have lost loved ones because it may cause inhibition of psychological adjustment.
• Very limited use of diazepam for women who are pregnant or breastfeeding under 6 months of age, because the drug can move to the placenta or be excreted in breast milk, leading to mental disabilities scripture for young children.
4. What is the dose of Diazepam 5mg?
Depending on the age and mental illness for which Diazepam 5mg is prescribed, patients may have some recommended dosages as follows:
Diazepam 5mg dosage for adults:
• For sedative effects, you should take about 2 - 10mg/day, corresponding to 1 - 2 Diazepam 5mg tablets/ day depending on your doctor's instructions, which should be divided into several daily doses.
• For treatment of alcohol withdrawal symptoms, initially, you need to take 2 Diazepam 5mg tablets/ time, within the first 24 hours, you should take it 3 times, each time 6 to 6 hours apart. After the first day, you can reduce to 1 pill/ time, 3 times daily.
• For the treatment of muscle spasms or epilepsy in adults, Diazepam 5mg is usually prescribed 1 - 2 tablets per day and should be divided into several doses (about 3 - 4 times) to take each day.
Diazepam 5mg dosage for children:
Children usually need to divide Diazepam 5mg with the following dosage:
• For the treatment of epilepsy, dosage ranges from 0.1 to 0.3 mg of drug per kg of body mass.
• To treat muscle spasms, children need to take about 0.12 to 0.8mg/ day per kg of body weight.
In fact, Diazepam 5mg is rarely prescribed for children because the Diazepam content in each tablet is relatively high. Instead, diazepam 2mg or injectable solution is more commonly used.
It can be said that Diazepam 5mg is a drug with mythical effects and fights many mental problems such as anxiety, stress, etc. However, you should not overuse the drug but need to combine it with more other psychology.
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