Rupatadine is utilized for managing the symptoms of allergies, with its active component being Rupatadine fumarate, classified as a second-generation H1 antihistamine. The following text elucidates the usage and potential side effects associated with this medication.
1. What is Rupatadine?
Rupatadine 10 mg contains the active ingredient Rupatadine fumarate at a concentration of 10 mg. It is a second-generation antihistamine with a prolonged antagonistic effect on histamine, selectively targeting peripheral H1 receptors.
2. Indications for the use of Rupatadine
Rupatadine is prescribed by healthcare professionals for the treatment of allergic rhinitis and urticaria in adults and adolescents over the age of 12.
3. Contraindications of Rupatadine
Rupatadine is contraindicated in individuals with hypersensitivity to any component of the medication.
4. Dosage and administration of Rupatadine
The dosage and administration of Rupatadine are as follows:
• Adults: The recommended dose of Rupatadine is 10 mg per tablet, administered once daily. Patients may take it with or without food.
• Children: The use of Rupatadine is not recommended for children under the age of 12. However, in children aged 2 to 11 years, a solution of Rupatadine 1 mg/ml may be prescribed.
• Elderly: Caution should be exercised when administering Rupatadine to this population.
• Patients with renal or hepatic impairment: Due to a lack of clinical experience and studies, the medication is not recommended for these patients.
5. Side effects of Rupatadine
• Common side effects include drowsiness, headache, fatigue, asthenia, dry mouth, and dizziness.
• Less common side effects: Pharyngitis, cough, dry throat, epistaxis, nasal dryness, sore throat, attention disturbances, diarrhea, gastrointestinal disturbances, nausea, vomiting, constipation, arthralgia, back pain, myalgia, thirst, irritability, weight gain, elevated creatine phosphokinase in blood, abnormal liver function tests.
• Rare side effects: Tachycardia, palpitations, and hypersensitivity reactions (including anaphylaxis, angioedema, and urticaria).
6. Precautions when using Rupatadine
• Rupatadine should be used with caution in patients with known prolonged QT intervals, patients with uncorrected hypokalemia, and those with persistent arrhythmias, such as clinically significant bradycardia and acute myocardial ischemia.
• Caution is also advised in elderly patients (aged 65 years and older).
• Pregnant women: Currently, there is limited data on the use of Rupatadine in pregnant women. Animal studies have not shown direct or indirect harm to pregnancy, fetal development, delivery, or postnatal development. Nonetheless, it is advisable to avoid the use of the drug during pregnancy.
• Breastfeeding women: It is not known whether Rupatadine is excreted in breast milk. Studies indicate that Rupatadine is secreted in milk in animals. The benefits of breastfeeding should be weighed against the benefits of the medication to the nursing mother.
• Caution when driving or operating machinery: At the recommended dosage, Rupatadine does not affect the ability to drive or operate machinery. However, patients should monitor their response to the medication before engaging in such activities.
Rupatadine 10 mg contains the active ingredient Rupatadine fumarate at a concentration of 10 mg and is prescribed for treating allergic rhinitis and urticaria in adults and adolescents over the age of 12. To ensure therapeutic efficacy and minimize unwanted side effects, patients should adhere to the prescribed regimen or consult a healthcare professional for guidance.
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