Ph.D Dao Thi Mai Lan


Dao Thi Mai Lan Ph.D has 12 years of research experience of Molecular Medicine and Genomics at multiple well-known Institute in Vietnam, South of Korea and France. Her outstanding achievements including:

  • The first person describe the novel regulatory element named Promoters which are promoters function as enhancer.

  • Develop the high-throughput reporter assay named Capstarr-seq for studying transcriptional regulatory elements.

  • Demonstrate the role of lncRNA in the development of leukemia.

  • Differentiate the mesenchymal stem cells toward insulin-producing cells and ameliorate the diabetes status when transplant these cells in mice.

Currently, Dr. Dao Thi Mai Lan is interested in applied research in gene therapy for the treatment of genetic diseases (beta thalassemia, hemophilia…) including gene transfer via lentiviral vector and the recent CRISPR/Cas9 technology.


Researcher in Gene Technology

  • 2017- Present: Gene technology specialist, Vinmec Research Institute of Stem Cell and Gene Technology (VRISG)

  • 2013 - 2016: Technology Advanced in Genomics and Clinics (TAGC), Marseille, France

  • 2009 - 2012: Lee Gil Ya Cancer and Diabetes Institute (LCDI), Incheon, South of Korea.

Books, articles, and research
  • Wiam Saadi, Yasmina Kermezli, Lan T.M. Dao, Evelyne Mathieu, David Santiago-Algarra, Iris Manosalva, Magali Torres, Mohamed Belhocine, Lydie Pradel, Beatrice Loriod, Mourad Aribi 3, Denis Puthier, Salvatore Spicuglia. A critical regulator of Bcl2 revealed by systematic transcript discovery of lncRNA associated with T-cell differentiation. Scientific report, 2019, accepted.

  • Le D-H, Dao LTM. Annotating Diseases Using Human Phenotype Ontology Improves Prediction of Disease-Associated Long Non-coding RNAs. J Mol Biol. 2018 May 23;

  • Dao, L. T. M. & Spicuglia, S. Transcriptional regulation by promoters with enhancer function. Transcription 0, 1–8 (2018).

  • Dao LTM, Galindo-Albarrán AO, Castro-Mondragon JA, Andrieu-Soler C, Medina-Rivera A, Souaid C, et al. Genome-wide characterization of mammalian promoters with distal enhancer functions. Nat Genet. 2017 Jun 5;

  • Santiago-Algarra D, Dao LTM, Pradel L, Espana A, Spicuglia S. Recent advances in high-throughput approaches to dissect enhancer function. F1000Research. 2017 Jun 19;6:939.

  • Dao LTM, Vanhille L, Griffon A, Fernandez N, Spicuglia S. CapStarr-seq protocol. Protoc Exch [Internet]. 2015 Oct 15; Available from: http://www.nature.com/protocolexchange/protocols/4333

  • Vanhille L, Griffon A, Maqbool MA, Zacarias-Cabeza J, Dao LTM, Fernandez N, et al. High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq. Nat Commun. 2015 Apr 15;6:6905.

  • Mathieu È-L, Belhocine M, Dao LTM, Puthier D, Spicuglia S. Rôle des longs ARN non codants dans le développement normal et pathologique. Médecine/sciences. 2014 Aug;30(8–9):790–6.

  • Dao LTM, Park E-Y, Lim S-M, Choi Y-S, Jung HS, Jun H-S. Transplantation of Insulin-Producing Cells Differentiated from Human Periosteum-Derived Progenitor Cells Ameliorate Hyperglycemia in Diabetic Mice: Transplantation. 2014 Nov;98(10):1040–7.

  • Dao LTM, Park E-Y, Hwang O-K, Cha J-Y, Jun H-S. Differentiation Potential and Profile of Nuclear Receptor Expression During Expanded Culture of Human Adipose Tissue-Derived Stem Cells Reveals PPARγ as an Important Regulator of Oct4 Expression. Stem Cells Dev. 2013 Sep 2;23(1):24–33.

  • Jun H-S, Dao LTM, Pyun J-C, Cho S. Effect of cell senescence on the impedance measurement of adipose tissue-derived stem cells. Enzyme Microb Technol. 2013 Oct 10;53(5):302–6.

  • Hwang O-K, Park E-Y, Dao LTM, Choi, Yun-Mi, Jun, Hee-Sook. Insulin-Producing cells differentiated from human adipose tissue-derived stem cells ameliorate hyperglycemia in diabetic mice. Tissue Eng Regen Med. 2011;8(5):482–8.

  • 2013 - 2016: Aix-Marseille University, Marseille, France

  • 2009 - 2011: Gachon University, Incheon, South of Korea

  • 2005 - 2009: Hanoi University of Science, Hanoi, Vietnam

Languages spoken

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