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Ph.D Nguyen Hong Thanh

About

Ph.D. Thanh Hong Nguyen has a broad experience working with Viral Protein Structure Biology, Molecular Biology and Genetics in different Institutions. He has involved in numerous scientific projects on relevant topics. Expertise and research of interests are included:

  • Gene therapy for genetic diseases treatment: including gene editing using CRISPR/Cas9 and gene transfer using virus-based vectors.

  • Molecular biology: genetic mutations identifications, genetic variant analysis, cloning and expression of interested gene.

  • Structure biology: structural and functional characterization of adenovirus fibre head for adenovirus-based vector development for gene therapy.

  • Protein biochemistry: protein expression and purification for medical uses, protein identification by LC/MS, gene/protein expression profiling for disease related diagnosis and treatment.

Roles

Researcher in Gene technology

Experience
  • 12/2018 - Present: Vinmec Research Institute of Stem Cell and Gene Technology.

  • 01/2018  - 12/2018: Institute of Biotechnology, Vietnam Academy of Science and Technology (IBT-VAST).

  • 10/2012 - 12/2017: Centro Nacional de Biotecnologia, CNB-CSIC, Madrid, Spain.

  • 03 - 12/2009: School of Biotechnology, Royal Institute of Technology (KTH), Stockholm, Sweden.

  • 04 - 11/2007: School of Biotechnology, Royal Institute of Technology (KTH), Stockholm, Sweden.

  • 2004 - 2007: Institute of Biotechnology, Vietnam Academy of Science and Technology (IBT-VAST).

Books, articles, and research
  • Singh AK, Nguyen TH, Vidovszky MZ, Harrach B, Benkő M, Kirwan A, Joshi L, Kilcoyne M, Berbis MÁ, Cañada FJ, Jiménez-Barbero J, Menéndez M, Wilson SS, Bromme BA, Smith JG, van Raaij MJ. (2018). Structure and N-acetylglucosamine binding of the distal domain of mouse adenovirus 2 fibre. Journal of General Virology 99: 1494-1508, doi: 10.1099/jgv.0.001145.

  • Kryshtafovych A., Albrecht R., Baslé A., Bule P., Caputo A.T., Carvalho A.L., Chao K.L., Diskin R., Fidelis K., Fontes C.M.G.A., Fredslund F., Gilbert H.J., Goulding C.W., Hartmann M.D., Hayes C.S., Herzberg O., Hill J.C., Joachimiak A., Kohring G.W., Koning R.I., Lo Leggio L., Mangiagalli M., Michalska K., Moult J., Najmudin S., Nardini M., Nardone V., Ndeh D., Nguyen T.H., Pintacuda G., Postel S., van Raaij M.J., Roversi P., Shimon A., Singh A.K., Sundberg E.J., Tars K., Zitzmann N., Schwede T. (2017). Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016). Proteins. doi: 10.1002/prot.25392. [Epub ahead of print].

  • Menéndez-Conejero R.*, Nguyen T.H.*, Singh A.K., Condezo G.N., Marschang R.E., van Raaij M.J., San-Martín C. (2017). Structure of a reptilian adenovirus reveals a phage tailspike fold stabilizing a vertebrate virus capsid. Structure. 25(10):1562-1573. (* Co-first author)

  • Nguyen, T.H., Ballmann, M.Z., Do, H.T., Truong, H.N., Benkő, M., Harrach, B., and van Raaij, M.J. (2016). Crystal structure of raptor adenovirus 1 fibre head and role of the beta-hairpin in sir adenovirus fibre head domains. Virology Journal. 13(1):106.

  • Nguyen, T.H., Thomas, C.M., Timson, D.J., and van Raaij, M.J. (2016). Fasciola hepatica calcium-binding protein FhCaBP2: structure of the dynein light chain-like domain. Parasitology Research. 115(7):2879-2886.

  • Singh A.K., Berbís M.Á., Ballmann M.Z., Kilcoyne M., Menéndez M., Nguyen T.H., Joshi L., Cañada F.J., Jiménes-Barbero J., Benkö M., Harrach B., van Raaij M.J. (2015). Structure and sialyllactose binding of the carboxy-terminal head domain of the fibre from a siadenovirus, turkey adenovirus 3. PLoS ONE 10(9): e0139339.

  • Nguyen T.H., Vidovszky M.Z., Ballmann M.Z., Sanz-Gaitero M, Singh A.K., Harrach B., Benkő M., and van Raaij M.J. (2015). Crystal structure of the fibre head domain of bovine adenovirus 4, a ruminant atadenovirus. Virology Journal. 12(1): 81.

  • Penzes J.J., Menendez-Conejero R., Condezo G.N., Ball I., Papp T., Doszpoly A., Paradela A., Perez-Berna A.J., Lopez-Sanz M., Nguyen T.H., van Raaij M.J., Marschang R.E., Harrach B., Benko M., San-Martin C. (2014). Molecular characterisation of a lizard adenovirus reveals the first atadenovirus with two fibre genes, and the first adenovirus with either one short or three long fibres per penton. J Virol. 88(19):11304-11314.

Education
  • 2016. Ph.D in Biology, major Biochemistry (Structural Biology) at Centro Nacional de Biotecnologia, CNB-CSIC, Madrid, Spain (joint program between CNB-CSIC and IBT-VAST).

  • 2009. Master of Science, major Applied Biology, Molecular Biology at Thai Nguyen University, Thai Nguyen, Vietnam.

  • 2004. Bachelor in Biotechnology, major Genetic and Molecular Biology in University of Science, Hanoi, Vietnam.

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